Use of sensors is increasing day-by-day in the real world to improve the quality of life by providing information on medical diagnostics for healthcare. Among numerous emerging sensing technologies, physical sensors "electronic devices" have been successfully demonstrated in the field of biomedical applications because of their excellent operation capability. Physical sensing is a unique sensing platform, where sensing devices are responsive towards physical properties (e.g., radiation, light, flow, heat, pressure, magnetic field, and parameters related to mass or energy) and convert them into signals for quantification. This review paper describes the different physical sensors and their biomedical applications, current main challenges, and future developments.