Monitoring of chemical transformations by mass spectrometry

Chun-Chi, Chen; Lin, Po‐Chiao

doi:10.1039/c5ay00496a

Cited by 21 publications

(24 citation statements)

References 113 publications

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“…ESI has been successfully used to disclose several mechanistic aspects of a plethora of catalyzed and noncatalyzed reactions, as discussed in several reviews. [76][77][78][79][80][81][82][83] The Brønsted acid-catalyzed Biginelli reaction mechanism was rst disclosed by ESI monitoring by Eberlin and co-workers. 84 Later, we demonstrated the Lewis acid-catalyzed Biginelli reaction mechanism 53 and some variations of Brønsted acid-catalyzed reactions.…”

Section: Resultsmentioning

confidence: 99%

Tuning the Biginelli reaction mechanism by the ionic liquid effect: the combined role of supported heteropolyacid derivatives and acidic strength

et al. 2019

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Section: Resultsmentioning

confidence: 99%

Tuning the Biginelli reaction mechanism by the ionic liquid effect: the combined role of supported heteropolyacid derivatives and acidic strength

et al. 2019

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“…Graham Cooks' group has introduced ESI variants that have found purchase in the organometallic community, notably desorption electrospray ionization (DESI) and direct spray (a catch‐all term for methods where an electrospray is generated from the sample under investigation) . DESI involves an electrospray plume which, instead of containing the analyte in solution, is directed at the analyte on a surface.…”

Section: Electrospray Ionization (Esi)mentioning

confidence: 99%

Ionization methods for the mass spectrometry of organometallic compounds

Vikse

McIndoe

2018

J Mass Spectrom

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The rapid development of new ionization methods has greatly expanded the ability of mass spectrometry to target diverse areas of chemistry. Synthetic organometallic and inorganic chemists often find themselves with interesting characterization problems that mass spectrometry could potentially find the answer for, but without a guide for choosing the appropriate method of analysis. This tutorial review seeks to provide that guidance via a simple flow chart followed by a brief description of how each common ionization method works. It covers all of the commonly used ionization techniques as well as promising variants and aims to be a resource of first resort for organometallic chemists and analysts tackling a new problem.

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“…The application of ambient ionization techniques to reaction monitoring has attracted much attention, however many of these techniques are most applicable to off‐line analysis due to the difficulty in presenting a representative sample of the reaction to the source on‐line. The many ionization techniques used in this application area have been reviewed . As the ambient ionization techniques are very extensive, a list of definitions can be found in the table of acronyms included in this manuscript.…”

Section: Ambient Ionizationmentioning

confidence: 99%

“…The many ionization techniques used in this application area have been reviewed. 43,44 As the ambient ionization techniques are very extensive, a list of definitions can be found in the table of acronyms included in this manuscript.…”

Section: Ambient Ionizationmentioning

confidence: 99%

On‐line reaction monitoring by mass spectrometry, modern approaches for the analysis of chemical reactions

Ray

Bristow

Whitmore

et al. 2017

Mass Spectrometry Reviews

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The application of on-line mass spectrometry for direct analysis of chemical and other types of process continues to grow in importance and impact. The ability of the technique to characterize many aspects of a chemical reaction such as product and impurity formation, along with reactant consumption in a single experiment is key to its adoption and development. Innovations in ionization techniques and mass spectrometry instrumentation are enabling this adoption. An increasing range of ambient ionization techniques make on-line mass spectrometry applicable to a large range of chemistries. The academic development and commercialization of small footprint portable/transportable mass spectrometers is providing technology that can be positioned with any process under investigation. These developments, coupled with research into new ways of sampling representatively from both the condensed and gaseous phases, are positioning mass spectrometry as an essential technology for on-line process optimization, understanding and intelligent control. It is recognized that quantitative capability of mass spectrometry in this application can cause some resistance to its adoption, but research activities to tackle this limitation are on-going.

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Monitoring of chemical transformations by mass spectrometry

Abstract: During the last several decades, mass spectrometry (MS) has rapidly developed as a practical technique that can be used to monitor chemical reactions and investigate reaction mechanisms.

Cited by 21 publications

References 113 publications

Tuning the Biginelli reaction mechanism by the ionic liquid effect: the combined role of supported heteropolyacid derivatives and acidic strength

Tuning the Biginelli reaction mechanism by the ionic liquid effect: the combined role of supported heteropolyacid derivatives and acidic strength

Ionization methods for the mass spectrometry of organometallic compounds

On‐line reaction monitoring by mass spectrometry, modern approaches for the analysis of chemical reactions

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