Monitoring of Enterobacteria strains with producing β-lactamases in males with infectious-inflammatory diseases of urogenital tract

Abstract

This article presents the findings of investigation of the microflora of 257 males with infectious-inflammatory diseases of the urogenital tract using the test system “Androflor”. The role of representatives of conditionally pathogenic microflora as the main etiological agent in occurrence of infectious-inflammatory diseases of the urogenital tract in males was shown. Its composition in 39.3±3.0% of cases was represented by bacteria of family Enterobacteriaceae, in 10.9±1.9% – by Enterococcus spp., in 3.1±1.1% – by Haemophilus spp. and in 0.4±0.1% of cases – by P. aeruginosa. Out of 101 strains of enterobacteria, 27 representatives had the ability to synthesize β-lactamases 26.7±4.4% of cultures), in particular: 16 isolates of E. coli, 5 isolates of P. mirabilis and 6 isolates of K. pneumoniae. The selected strains of enterobacteria producing β-lactamases appeared to be resistant at least to 6 tested antibiotics, which allowed referring them to categories of multi-resistant. All cultures producing β-lactamases showed resistance to penicillinеs – ampicillin and amoxiclav. In this case, resistance to at least one of the antibiotics of cephalosporin group of the third generation was noted. In addition, 83.3±2.1% of the examined isolates were characterized by resistance to macrolides – erythromycin and azithromycin, as well as to co-trimoxazole and fosfomicin. The obtained data are of practical importance to develop efficient schemes of antibiotic therapy for infectious-inflammatory diseases of the urogenital tract, caused by strains of enterobacteria producing β-lactamases.