Innovative subsea production systems (SPS) are required for deep-water oil and gas exploration in order to transport multiphase fluids—a complex mixture of water, gas, and oil—across long distances under challenging conditions. Significant technological challenges confront these systems, such as flow assurance, which ensures continuous fluid flow through pipelines, flowlines, and wells. Flow assurance issues can significantly impact production and incur costly downtime. This paper emphasizes the critical role of flow assurance analysis during the crucial Front-End Engineering Design (FEED) stage of SPS development. By utilizing industry-standard simulation tools like PIPESIM™, engineers can proactively identify and mitigate potential flow assurance problems that could hinder productivity. These analyses are crucial as FEED decisions significantly impact project cost-effectiveness. To illustrate the practical application of flow assurance principles, the paper presents a case study of a subsea architecture design for a specific manifold system. Considering operator requirements, flow assurance simulations were employed to guide critical decisions regarding material selection and optimal sizing of risers and flowlines. This demonstrates how flow assurance considerations during FEED directly influence cost-effective and optimized SPS design.