“…Prior to the introduction of vaccines, it was estimated that approximately all children under the age of 5 had been infected with rotavirus; 352,000 to 592,000 children under the age of 5 are estimated to die each year from rotavirus infections, and 82% of these deaths occurred among children in low-income countries (12). Rotavirus is transmitted from person to person via the fecal-oral route (11,13). It can also be transmitted through fecal-contaminated water, especially in developing countries (11,14).…”