Monitoring of inflammation in relation to pathophysiology

Ventilation and Perfusion Lung Scintigraphy of Allergen‐Induced Airway Responses in Atopic Asthmatic Subjects

“…Inequalities in V and Q, which play a central role in hypoxia, have also been studied by other lung imaging techniques (5,15) that have been employed to visualise allergen-invoked airway inflammation (7,25). With a better understanding of the inflammatory mediators (26) involved in the pathophysiology of asthma, early and late asthmatic responses are clearly recognized (16). However, attempts to correlate lung scan abnormalities with the dynamic sequence of an asthmatic attack have been few (9-11), partly because of difficulties with the quantification of lung scan abnormalities (27) and partly because of failure to obtain objective physiological data at the time of scanning.…”

“…abnormalities (15) and failure to obtain objective data on asthma severity at the time of scanning (5,16).…”