Monitoring of Microfluidics Systems for PET Radiopharmaceutical Synthesis Using Integrated Silicon Photomultipliers

Salvador, Blas; Pineda, Diego Andres Escalante; Fernández-Maza, Laura; Corral, Ariadna; Camacho-León, Sergio; Luque, A.

doi:10.1109/jsen.2019.2917362

Cited by 10 publications

(5 citation statements)

References 26 publications

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“…Besides the general advantages of microfluidic synthesis over batch processes, in this case, it should also be mentioned that this technology is compatible with the dose-on-demand approach, allowing the production of a single dose of a tracer when a single PET scan is needed, with the possibility to restart synthesis whenever a new dose is required as well. As the reaction, purification, formulation, and quality control are all performed on a single small, disposable chip, the environmental impact is also reduced [ 115 , 116 , 117 ].…”

Section: Applications Of Microfluidic Devicesmentioning

confidence: 99%

Fabrication and Applications of Microfluidic Devices: A Review

Niculescu

Chircov

Bîrcă

et al. 2021

IJMS

386

208

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Microfluidics is a relatively newly emerged field based on the combined principles of physics, chemistry, biology, fluid dynamics, microelectronics, and material science. Various materials can be processed into miniaturized chips containing channels and chambers in the microscale range. A diverse repertoire of methods can be chosen to manufacture such platforms of desired size, shape, and geometry. Whether they are used alone or in combination with other devices, microfluidic chips can be employed in nanoparticle preparation, drug encapsulation, delivery, and targeting, cell analysis, diagnosis, and cell culture. This paper presents microfluidic technology in terms of the available platform materials and fabrication techniques, also focusing on the biomedical applications of these remarkable devices.

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Section: Applications Of Microfluidic Devicesmentioning

confidence: 99%

Fabrication and Applications of Microfluidic Devices: A Review

Niculescu

Chircov

Bîrcă

et al. 2021

IJMS

386

208

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“…136 Another effective method has been to use silicon photomultiplier (SiPM) chips that yield reliable detection based off direct interaction with beta particles. [137][138][139][140] However, this interaction requires that the detector is very close to the microfluidic channel, which may not be possible for some designs. Scintillators have been used as an intermediate material to enhance the signal from positron interactions, 141 and as a standalone detection device.…”

Section: Safety and Regulatory Considerationsmentioning

confidence: 99%

Microfluidic synthesis of radiotracers: recent developments and commercialization prospects

Mc Veigh,

Bellan

2024

Lab Chip

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“…Tarn et al used an SiPM array adjacent a thin plastic scintillator containing a machined 0.7 μL flow cell, 42 in which each SiPM element monitored a localized region of the chip. Interestingly, SiPM pixels have also been used to directly detect positrons without a scintillator, as shown by Taggart 43 and Salvador, 44 though the efficiency was quite low due to a relatively large source-to-detector distance. One disadvantage of SiPMs is the difficulty in eliminating thermal noise that becomes problematic at low radioactivity levels.…”

Section: Metrics and Morementioning

confidence: 99%

Integration of High-Resolution Radiation Detector for Hybrid Microchip Electrophoresis

Jones

Barajas

et al. 2020

Anal. Chem.

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For decades, there has been immense progress in miniaturizing analytical methods based on electrophoresis to improve sensitivity and to reduce sample volumes, separation times, and/or equipment cost and space requirements, in applications ranging from analysis of biological samples to environmental analysis to forensics. In the field of radiochemistry, where radiation-shielded laboratory space is limited, there has been great interest in harnessing the compactness, high efficiency, and speed of microfluidics to synthesize short-lived radiolabeled compounds. We recently proposed that analysis of these compounds could also benefit from miniaturization and have been investigating capillary electrophoresis (CE) and hybrid microchip electrophoresis (hybrid-MCE) as alternatives to the typically used highperformance liquid chromatography (HPLC). We previously showed separation of the positron-emission tomography (PET) imaging tracer 3′-deoxy-3′-fluorothymidine (FLT) from its impurities in a hybrid-MCE device with UV detection, with similar separation performance to HPLC, but with improved speed and lower sample volumes. In this paper, we have developed an integrated radiation detector to enable measurement of the emitted radiation from radiolabeled compounds. Though conventional radiation detectors have been incorporated into CE systems in the past, these approaches cannot be readily integrated into a compact hybrid-MCE device. We instead employed a solid-state avalanche photodiode (APD)-based detector for real-time, high-sensitivity β particle detection. The integrated system can reliably separate [ 18 F]FLT from its impurities and perform chemical identification via coinjection with nonradioactive reference standard. This system can quantitate samples with radioactivity concentrations as low as 114 MBq/mL (3.1 mCi/mL), which is sufficient for analysis of radiochemical purity of radiopharmaceuticals.

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Monitoring of Microfluidics Systems for PET Radiopharmaceutical Synthesis Using Integrated Silicon Photomultipliers

Cited by 10 publications

References 26 publications

Fabrication and Applications of Microfluidic Devices: A Review

Fabrication and Applications of Microfluidic Devices: A Review

Microfluidic synthesis of radiotracers: recent developments and commercialization prospects

Integration of High-Resolution Radiation Detector for Hybrid Microchip Electrophoresis

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