Monitoring of PAEMs and beta-agonists in urine for a small group of experimental subjects and PAEs and beta-agonists in drinking water consumed by the same subjects

Liou, Saou-Hsing; Yang, Gordon C.C.; Wang, Chih-Lung; Chiu, Yu‐Han

doi:10.1016/j.jhazmat.2014.02.024

Cited by 32 publications

(27 citation statements)

References 44 publications

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“…Liquid samples should be stored in a refrigerated chamber at 4°C (± 3°C) in darkness and treated (i.e., extraction, analysis) as soon as possible within a maximum period of 14 days to reduce losses by adsorption on the walls of the container (EPA, 1995). While solid sample should be stored at -20°C until the treatment can be performed (He et al, 2013;Liou et al, 2014;Wang et al, 2013).…”

Section: Sample Storage and Transportmentioning

confidence: 99%

“…However, their extensive use and permanent emissions have resulted in their ubiquitous presence in the environment. PAEs have been widely detected throughout the worldwide environment, including atmospheric aerosols and air (Barreca et al, 2014;Fu et al, 2009;Wang et al, 2014;Xie et al, 2007), in municipal solid waste compost (Farrell et al, 2009), sludge from sewage and wastewater treatment (Dargnat et al, 2009;Reid et al, 2009), river and marine waters/sediments (Blair et al, 2009;Net et al, 2014;Xie et al, 2007), wastewater (Gao et al, 2014) and in drinking water (Gao et al, 2014;Liou et al, 2014). Indoor air where people spend 65-90% of their time is also highly contaminated by various PAEs released from plastics, consumer products within homes, suspended particulate matters and house dusts (Pei et al, 2013;Wang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reliable quantification of phthalates in environmental matrices (air, water, sludge, sediment and soil): A review

Net

Delmont

Sempéré

et al. 2015

Science of The Total Environment

225

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Because of their widespread application, phthalates or phthalic acid esters (PAEs) are ubiquitous in the environment. Their presence has attracted considerable attention due to their potential impacts on ecosystem functioning and on public health, so their quantification has become a necessity. Various extraction procedures as well as gas/liquid chromatography and mass spectrometry detection techniques are found as suitable for reliable detection of such compounds. However, PAEs are ubiquitous in the laboratory environment including ambient air, reagents, sampling equipment, and various analytical devices, that induces difficult analysis of real samples with a low PAE background. Therefore, accurate PAE analysis in environmental matrices is a challenging task. This paper reviews the extensive literature data on the techniques for PAE quantification in natural media. Sampling, sample extraction/pretreatment and detection for quantifying PAEs in different environmental matrices (air, water, sludge, sediment and soil) have been reviewed and compared. The concept of "green analytical chemistry" for PAE determination is also discussed. Moreover useful information about the material preparation and the procedures of quality control and quality assurance are presented to overcome the problem of sample contamination and these encountered due to matrix effects in order to avoid overestimating PAE concentrations in the environment.

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Section: Sample Storage and Transportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reliable quantification of phthalates in environmental matrices (air, water, sludge, sediment and soil): A review

Net

Delmont

Sempéré

et al. 2015

Science of The Total Environment

225

View full text Add to dashboard Cite

show abstract

“…69,70 In urine, metabolites of DnBP and DEHP were the main PAEs metabolites (PAEMs) detected. 69 Urinary PAEMs concentrations did not depend on sexes but they depend significantly on age. 69 The most frequently detected PAEs were reported to be DnBP and DEHP, found at highest levels in venous blood followed by breast milk, umbilical cord blood and urine; this order depends on metabolic factors.…”

Section: ■ Introductionmentioning

confidence: 99%

Occurrence, Fate, Behavior and Ecotoxicological State of Phthalates in Different Environmental Matrices

Net

Sempéré

Delmont

et al. 2015

Environ. Sci. Technol.

959

357

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Because of their large and widespread application, phthalates or phthalic acid esters (PAEs) are ubiquitous in all the environmental compartements. They have been widely detected throughout the worldwide environment. Indoor air where people spend 65-90% of their time is also highly contaminated by various PAEs released from plastics, consumer products as well as ambient suspended particulate matter. Because of their widespread application, PAEs are the most common chemicals that humans are in contact with daily. Based on various exposure mechanisms, including the ingestion of food, drinking water, dust/soil, air inhalation and dermal exposure the daily intake of PAEs may reach values as high as 70 μg/kg/day. PAEs are involved in endocrine disrupting effects, namely, upon reproductive physiology in different species of fish and mammals. They also present a variety of additional toxic effects for many other species including terrestrial and aquatic fauna and flora. Therefore, their presence in the environment has attracted considerable attention due to their potential impacts on ecosystem functioning and on public health. This paper is a synthesis of the extensive literature data on behavior, transport, fate and ecotoxicological state of PAEs in environmental matrices: air, water, sediment, sludge, wastewater, soil, and biota. First, the origins and physicochemical properties of PAEs that control the behavior, transport and fate in the environment are reviewed. Second, the compilation of data on transport and fate, adverse environmental and human health effects, legislation, restrictions, and ecotoxicological state of the environment based on PAEs is presented.

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“…Ractopamine residues have been investigated in urine collected from individuals (n = 21) in Taiwan; 30 negative findings in Taiwan are not surprising since β-agonists are banned from use in food animals in the country. In this study, in urine samples from two groups of patients with newly-diagnosed breast and lung cancer, detectable levels of ractopamine or zilpaterol occurred, albeit in a low number of samples and at very low concentrations.…”

Section: Discussionmentioning

confidence: 99%

Urinary Excretion of the β-Adrenergic Feed Additives Ractopamine and Zilpaterol in Breast and Lung Cancer Patients

Cheng

Shelver

Hong

et al. 2016

J. Agric. Food Chem.

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β2-adrenergic agonists (β-agonists) have been legally used in the U.S. for almost two decades to increase lean muscle mass in meat animals. Despite a cardiotoxic effect after high-dose exposure, there has been limited research on human β-agonist exposures related to meat consumption. We quantified urinary concentrations of ractopamine and zilpaterol, two FDA-approved β-agonist feed additives, and examined the extent to which the concentrations were associated with estimated usual meat intake levels. Overnight urine samples from 324 newly diagnosed breast cancer patients and spot urine samples from 46 lung cancer patients at the time of diagnosis, prior to treatment, were collected during 2006–2010 and 2014–2015, respectively. Urinary ractopamine and zilpaterol concentrations were measured by LC-MS/MS. Ractopamine and zilpaterol, respectively, were detected in 8.1% and 3.0% of the urine samples collected (n=370). Only 1.1% (n=4) of the urine samples had zilpaterol concentrations above the limit of quantification, with the mean value of 0.07 ng/mL in urine. The presence of detectable ractopamine and zilpaterol levels were not associated with meat consumption estimated from a food frequency questionnaire, including total meat (P=0.13 and 0.74, respectively), total red meat (P=0.72 and 0.74), unprocessed red meat (P=0.74 and 0.73), processed red meat (0.72 and 0.15), and poultry intake (P=0.67 for ractopamine). Our data suggest that the amount of meat-related exposure of β-agonists was low.

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Monitoring of PAEMs and beta-agonists in urine for a small group of experimental subjects and PAEs and beta-agonists in drinking water consumed by the same subjects

Cited by 32 publications

References 44 publications

Reliable quantification of phthalates in environmental matrices (air, water, sludge, sediment and soil): A review

Reliable quantification of phthalates in environmental matrices (air, water, sludge, sediment and soil): A review

Occurrence, Fate, Behavior and Ecotoxicological State of Phthalates in Different Environmental Matrices

Urinary Excretion of the β-Adrenergic Feed Additives Ractopamine and Zilpaterol in Breast and Lung Cancer Patients

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