Monitoring of polychlorinated biphenyls in Belgian human adipose tissue samples

Saeger, Sarah De; Sergeant, H.; Piette, M; Bruneel, Noël; Voorde, Wim Van de; Peteghem, Carlos Van

doi:10.1016/j.chemosphere.2004.09.069

Cited by 39 publications

(23 citation statements)

References 13 publications

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“…Only 20 PCB congeners were frequently detected in samples, which included all 7 marker PCBs (i.e., PCBs 28, 52, 101, 118, 138, 153, and 180). The total PCB concentration ranged between 0 and 387 µg/kg fat with a mean value of 27.2 µg/kg fat Figure 2, indicating that the concentrations of PCBs in human adipose tissues in these two Chinese southeastern sites are much lower than those in European countries (2,6,21,23,24) but comparable to those in Japan (22) and Chile (23). The reason could be attributed to the longer history and larger amount of industrial PCB production in the European countries including Spain, Belgium, Turkey, Italy, and Sweden.…”

Section: Resultsmentioning

confidence: 90%

Levels of Polychlorinated Biphenyls in Human Adipose Tissue Samples from Southeast China

Wang

Kong

Cai

et al. 2010

Environ. Sci. Technol.

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This paper presents a comprehensive study of polychlorinated biphenyl (PCB) levels and homologue profiles in human adipose tissues among residents of Southeast China. A large number of samples (n = 303) were selected for a number of PCB congeners (n = 62) which were analyzed by highly sensitive gas chromatography-tandem mass spectrometry (GC-MS/MS). The total mean PCB concentrations were 27.2 microg/kg fat (n = 159) in Anhui Province and 17.2 microg/kg fat (n = 144) in Jiangsu Province. A significant correlation was observed between age and PCB levels but not found between gender and PCB levels. The relationship between the environmental contaminant levels and the PCB concentration in adipose tissue was also investigated. It was found that the higher PCB concentrations in human adipose tissue were associated with the higher environmental PCB levels in the corresponding regions. The PCB homologue profiles of the human adipose tissue in China are different from those in the world, similarly to the different PCB homologue pattern between Chinese and global soils. The concept of the urban fractionation effect in the environment may be applicable to explain the PCB homologue profiles and PCB levels in the human adipose tissues collected from different provinces in China. The data presented in this study can provide useful information on human exposures to PCBs in the general population of Southeast China.

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Section: Resultsmentioning

confidence: 90%

Levels of Polychlorinated Biphenyls in Human Adipose Tissue Samples from Southeast China

Wang

Kong

Cai

et al. 2010

Environ. Sci. Technol.

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“…An age-associated increase in the PCB body burden has been emerging as a common phenomenon in many countries in recent studies [8][9][10][11]. However, most of the observations have been based on samples collected at a single time point.…”

Section: Introductionmentioning

confidence: 99%

Paradoxical increases in serum levels of highly chlorinated PCBs in aged women in clear contrast to robust decreases in dietary intakes from 1980 to 2003 in Japan

Harada

Eslami

Fujimine

et al. 2009

Environ Health Prev Med

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Objective Exposure to polychlorinated biphenyls (PCBs) is considered to have culminated between 1950 and 1970 in Japan, and exposure through diet, the major exposure route, has decreased significantly over the last 10 years. The primary goal of the present study was to investigate the long-term trends and congener profiles of serum and dietary levels of PCBs using historical samples. -009-0089-6 serum total PCB level (ng/g lipid) in women \40 years of age decreased significantly from 185 (1.8) in 1980 to 68 (1.8) in 2003. In contrast, the level in women [50 years of age increased significantly from 125 (1.7) in 1980 to 242 (1.7) in 2003. Specifically, the serum concentrations of hexa (#138, #146, #153, #156, #163, and #164) and hepta (#170, #180, #182, and #187) congeners increased significantly. A comparison of the serum PCB levels of women born from 1940 to 1953 revealed that their serum total PCB level was significantly higher in the 2003 survey [242 (1.7), n = 9] than in the 1995 [128 (2.0), n = 17] surveys. This increase in the total PCB level was attributable to increases in the hepta congener groups. Conclusion Present results suggest a decreased rate of elimination of hepta congeners with aging in females, rather than a birth-generation phenomenon. Methods123 Environ Health Prev Med (2009) 14:235-246 DOI 10.1007/s12199

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“…The doses of PCBs we used were applied in animals and in humans (De Saeger et al, 2005), and in our previous studies the same doses were used to measure the effect of PCBs on the contractions of bovine myometrium (Wrobel et al, 2005). The doses of phytoestrogens we used were similar to those used by Miksicek (1993), Ruh et al (1995), Stromeier et al (2005) and were also similar to those found in urine and blood plasma of cows fed soybean (Woclawek-Potocka et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Influence of polychlorinated biphenyls (PCBs) and phytoestrogens on prostaglandin F<sub>2α</sub> and E<sub>2</sub>secretion from bovine endometrial cells at a postovulatory stage of the estrous cycle

Wróbel¹,

Kotwica²

2005

Vet. Med. - Czech

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Polychlorinated biphenyls (PCBs) and phytoestrogens were found to affect contractions of bovine uterus. Prostaglandins (PG) F 2α and E 2 are also involved in the uterine contractility. Hence the aim of these studies was to investigate the effect of PCBs and some phytoestrogens on PG secretion from endometrial cells obtained on days 1-5 of the oestrous cycle. Cells were incubated in aerated atmosphere at 38°C for 24 h, separately with the mixture of PCBs -Aroclor 1248 (10 ng/ml), with individual congeners -77, -126 or -153 (each at the dose 100 g/ml), coumestrol, daidzein or genistein (each at the dose 10 -6 M) or jointly each PCB with each of the phytoestrogens. Using the TOX1-kit neither Aroclor 1248 (Ar 1248) nor individual congeners were found to affect the viability of cells compared to the control (P > 0.05). All used PCBs markedly increased the metabolite of PGF 2α (PGFM) concentrations (P < 0.05) but not PGE 2 (P > 0.05). Hence the ratio of PGF 2α to PGE 2 was also increased by PCBs. However, when these cells were incubated with each of the phytoestrogens, there was a decrease in both PGF 2α and PGE 2 secretion compared to the control (P < 0.05) but without altering the PGF 2α : PGE 2 ratio. Moreover, phytoestrogens could clearly reduce the concentrations of PGFM elicited by PCBs, and they reduced PGE 2 secretion compared to that evoked by PCB-126 and -153 only. Thus phytoestrogens can restore the proper ratio of PGF 2α : PGE 2 secreted by the bovine endometrium.

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Monitoring of polychlorinated biphenyls in Belgian human adipose tissue samples

Cited by 39 publications

References 13 publications

Levels of Polychlorinated Biphenyls in Human Adipose Tissue Samples from Southeast China

Levels of Polychlorinated Biphenyls in Human Adipose Tissue Samples from Southeast China

Paradoxical increases in serum levels of highly chlorinated PCBs in aged women in clear contrast to robust decreases in dietary intakes from 1980 to 2003 in Japan

Influence of polychlorinated biphenyls (PCBs) and phytoestrogens on prostaglandin F<sub>2α</sub> and E<sub>2</sub>secretion from bovine endometrial cells at a postovulatory stage of the estrous cycle

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