Monitoring of tumor cells by flow cytometry permits rapid evaluation of disease progression in monomorphic epitheliotropic intestinal T‐cell lymphoma

Abstract

Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a primary intestinal T-cell lymphoma proposed as a new disease entity in the revised fourth World Health Organization classification. Recent reports showed that MEITL is characterized by a poor prognosis and a high frequency of local relapse and extra-intestinal involvement, including the central nervous system (CNS)

Issue Highlights—July 2021

“…One common application of flow cytometry is the evaluation of body fluids for involvement by neoplastic cells (Berg et al, 2021; Del Principe et al, 2021; Eidhof et al, 2021; Galán et al, 2019). Umino and colleagues illustrate the usefulness of flow cytometry in identifying neoplastic cells in pleural and cerebrospinal fluid specimens from a patient with monomorphic epitheliotropic intestinal T‐cell lymphoma (Umino et al, 2021). Enumeration of CD34+ hematopoietic stem and progenitor cells has long been accomplished by flow cytometry (Saraiva et al, 2019); in the current issue, Lowes and colleagues demonstrate that a commercially‐available lysing reagent may obviate the requirement for daily preparation of NH 4 Cl (Lowes et al, 2021).…”