Monitoring of twenty-two sulfonamides in edible tissues: Investigation of new metabolites and their potential toxicity

Abdallah, Hiba; Arnaudguilhem, Carine; Haifa, Abdul Rahim; Łobiński, Ryszard; Jaber, Farouk

doi:10.1016/j.foodchem.2015.06.093

Cited by 36 publications

(12 citation statements)

References 36 publications

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“…HPLC-ESI-MS was used for the analysis of carotenoids [6], anthocyanins [7], phenolic acids [8] and alkaloids [9] in edible fruits and flowers, among other constituents. The Q-Exactive Focus is a recently released hybrid high resolution mass spectrometer with an innovative technology which delivers high resolution MS / MS fragments for metabolomics analysis of a variety of species, including toxins, pesticides, antibiotics, peptides and several small organic molecules up to 2000 amu [10,11]. Since we were not able to find HPLC-MS analysis nor phytochemical compounds reported from this Chilean pear variety, and continuing our search for interesting polyphenols in native Chilean plants [12,13,14,15,16] in the present work the polyphenolic fingerprints and phenolic content of edible pears (Figure 1) from the II region of Chile (collected in Toconao, an oasis located at the northeastern edge of the Salar de Atacama) were correlated with the antioxidant capacities measured by the bleaching of the DPPH radical, the ferric reducing antioxidant power (FRAP) and the superoxide anion scavenging activity assay (SA).…”

Section: Introductionmentioning

confidence: 99%

Fast Detection of Phenolic Compounds in Extracts of Easter Pears (Pyrus communis) from the Atacama Desert by Ultrahigh-Performance Liquid Chromatography and Mass Spectrometry (UHPLC–Q/Orbitrap/MS/MS)

et al. 2016

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Abstract:A small Chilean variety of pears growing in the town of Toconao, an oasis located at the northeastern edge of the Salar de Atacama, northern Chile, was studied by means of modern PDA and high resolution mass spectral data (UHPLC-PDA-HESI-orbitrap-MS/MS). In addition, the antioxidant features of the fruits were compared with the varieties Packhman's Triumph and Abate Fetel and correlated with the presence of phenolic compounds. The non-pigmented phenolics were fingerprinted and related to the antioxidant capacities measured by the bleaching of the DPPH radical, the ferric reducing antioxidant power (FRAP), the superoxide anion scavenging activity assay (SA), and total content of phenolics and flavonoids measured by spectroscopic methods. The machine allowed a fast separation of 15 min employing a flow rate of 1 mL per minute and could accurately identify 25 compounds, including several isorhamnetin derivatives and phenolic acids, present in the peel and pulps of this Chilean variety for the first time. The compounds were monitored using a wavelength range of 210-800 nm. The native small Chilean pear showed the highest antioxidant activity measured as the bleaching of the DPPH radical, the ferric reducing antioxidant power and superoxide anion scavenging activity (8.61˘0.65 µg/mL, 712.63˘12.12 micromols trolox equivalents (µmol/TE)/100 g FW, and 82.89%˘2.52% at 100 µg/mL, respectively).

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Section: Introductionmentioning

confidence: 99%

Fast Detection of Phenolic Compounds in Extracts of Easter Pears (Pyrus communis) from the Atacama Desert by Ultrahigh-Performance Liquid Chromatography and Mass Spectrometry (UHPLC–Q/Orbitrap/MS/MS)

et al. 2016

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“…They are among the pharmaceutical antibiotics used to treat or prevent bacterial infection, diabetes mellitus, edema, hypertension, and gout-associated problems (Hiba et al 2016). In European countries, sulfonamides are one of the groups of antibiotics administered most widely in animal husbandry; approximately 363,000 kg of sulfamethazine (SMT), a group of sulfonamides, is used in swine production every year Raich-Montiu et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Removal of sulfamethazine antibiotics using cow manure-based carbon adsorbents

Tzeng

Liu

Deng

et al. 2016

Int. J. Environ. Sci. Technol.

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Low-cost adsorbents, e.g., cow manure-based carbon, provide alternatives to remove veterinary antibiotic sulfamethazine (SMT) from contaminated water bodies. In this study, the chemical structures and compositions of cow manure (CM) carbonized at 400, 600, and 800°C (CM400, CM600, and CM800) were examined using elemental analyzer (EA), Brunauer-Emmett-Teller, and spectroscopic techniques. Adsorptions of SMT on CM samples were conducted as functions of pH, hydrophobicity, and ionic strengths. Results of EA and spectroscopic analyses suggested that the raw CM and CM400 samples contained the highest amounts of O-containing groups and aliphatic domains. Amounts of such two chemical groups decreased as carbonization temperatures increased. The specific surface areas and total pore volumes of CM samples increased significantly when the carbonization temperatures exceeded 600°C. SMT adsorption on CM samples could be described essentially by the pseudo-second-order kinetic, intra-particle diffusion, and Freundlich isotherm models. Low pH and ionic strength were favorable for SMT adsorption in CM samples, particularly for the CM800, because a strong p ? -p electron donor-acceptor interaction (p ? -p EDA) was formed between SMT and CM surfaces enriched with hydrophobic domains. Further, the high adsorption affinity of SMT to the CM600 and CM800 samples was attributed in part to their larger surface areas and total pore volumes. Generally, CM-based materials carbonized [600°C showed relatively stable structures and exhibited strong aromatic properties. Moreover, maximum adsorption capacities of SMT on the CM800 sample (37-39 mM/kg) were significantly higher than those of other common adsorbents (0.02-35.93 mM/kg).

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“…However, misuse can lead to residues in food animals and the environment. Excessive SDZ in food and the environment can have harmful effects, such as anaphylactic reactions (Hiba, Carine, Haifa, Ryszard, & Farouk, 2016), poisoning (Khalili, Soudbakhsh, & Talasaz, 2011), kidney failure or urinary stones (Dognon, Degand, Douny, Delahaut, Igout, Dahouda, Youssao, & Scippo, 2018). A rapid and sensitive analytical approach for the determination of SDZ is urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Development of novel biomimetic enzyme-linked immunosorbent assay method based on Au@SiO₂ nanozyme labelling for the detection of sulfadiazine

Liu

Jiang

et al. 2020

Food and Agricultural Immunology

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In the current study, a rapid and novel biomimetic nano-enzymelinked immunosorbent assay has been established for the detection of sulfadiazine (SDZ) using Au@SiO 2 nanoparticles labelling as a marker. In this system, gold nanoparticles exhibited intrinsic peroxidase and activity with excellent water-solubility, and the SiO 2 nanoparticles as ideal carries possessed a large surface area and ease of surface functionalization. The molecularly imprinted polymer films were selected as bionic antibody because of its advantages of selective recognition and reusability. Combine the above advantages, the method exhibited good stability, recognition capability and sensitivity. Under the optimal condition, the limit of detection of the immunosorbent assay was 0.2 mg/L. Beef sample spiked with SDZ was analysed, and the recoveries were in the 78.00% to 90.96% range. The assay could be used to detect SDZ residues in pork and chicken samples, and the results were not significantly different from those obtained by highperformance liquid chromatography.

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Monitoring of twenty-two sulfonamides in edible tissues: Investigation of new metabolites and their potential toxicity

Cited by 36 publications

References 36 publications

Fast Detection of Phenolic Compounds in Extracts of Easter Pears (Pyrus communis) from the Atacama Desert by Ultrahigh-Performance Liquid Chromatography and Mass Spectrometry (UHPLC–Q/Orbitrap/MS/MS)

Fast Detection of Phenolic Compounds in Extracts of Easter Pears (Pyrus communis) from the Atacama Desert by Ultrahigh-Performance Liquid Chromatography and Mass Spectrometry (UHPLC–Q/Orbitrap/MS/MS)

Removal of sulfamethazine antibiotics using cow manure-based carbon adsorbents

Development of novel biomimetic enzyme-linked immunosorbent assay method based on Au@SiO₂ nanozyme labelling for the detection of sulfadiazine

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Monitoring of twenty-two sulfonamides in edible tissues: Investigation of new metabolites and their potential toxicity

Cited by 36 publications

References 36 publications

Fast Detection of Phenolic Compounds in Extracts of Easter Pears (Pyrus communis) from the Atacama Desert by Ultrahigh-Performance Liquid Chromatography and Mass Spectrometry (UHPLC–Q/Orbitrap/MS/MS)

Fast Detection of Phenolic Compounds in Extracts of Easter Pears (Pyrus communis) from the Atacama Desert by Ultrahigh-Performance Liquid Chromatography and Mass Spectrometry (UHPLC–Q/Orbitrap/MS/MS)

Removal of sulfamethazine antibiotics using cow manure-based carbon adsorbents

Development of novel biomimetic enzyme-linked immunosorbent assay method based on Au@SiO2 nanozyme labelling for the detection of sulfadiazine

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Product

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Development of novel biomimetic enzyme-linked immunosorbent assay method based on Au@SiO₂ nanozyme labelling for the detection of sulfadiazine