Monitoring of whole-body hyperthermia with transesophageal echocardiography (TEE)

Fippel, A.; Sandersleben, Alexandra von; Bangert, Katrin; Horn, Jeannette; Nierhaus, Axel; Wappler, Frank

doi:10.1080/02656730701558509

Cited by 3 publications

(4 citation statements)

References 26 publications

(34 reference statements)

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“…Moreover, this hyperthermia-induced elevation in heart rate has been previously reported. 8-10,12,13 CVP was stable in our study, demonstrating our ability to adequately maintain/balance blood volume.…”

Section: Discussionsupporting

confidence: 61%

“…8,12,16 Prolonged heating times (2-3 hrs) are also needed to reach the desired therapeutic temperature. 8,12,13 Most importantly, patient complications such as severe skin burns and peripheral neuropathy seriously impact quality of life. 8,12,14,16 By contrast, vv-PISH extracorporeal circuits are invasive, but provide homogeneous internal heating with no severe skin burns.…”

Section: Discussionmentioning

confidence: 99%

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Physiologic Response to a Simplified Venovenous Perfusion-Induced Systemic Hyperthermia System

Ballard-Croft

Wang²,

Jones³

et al. 2012

ASAIO Journal

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Our original venovenous perfusion-induced systemic hyperthermia (vv-PISH) system appeared to significantly improve lung cancer patient survival, but was too complex with numerous dialysis problems. We tested a simplified vv-PISH circuit that includes the AvalonElite double lumen cannula, a modified heat exchanger, water heater/cooler, and a centrifugal pump. The purpose of this study was to evaluate this simplified vv-PISH system (without hemodialyzer) and to investigate the physiological response to whole body hyperthermia in pigs. We tested our vv-PISH circuit in healthy female adult swine (n= 7, 55-68 kg). The therapeutic core temperature (42°C), calculated as mean of rectal, bladder, and esophageal temperatures, was achieved in six swine. A maximum difference of 0.5°C was observed between the individual temperature sensor readings, indicating homogeneous heat distribution. Heart rate and mean arterial pressure were transiently altered, but were safely managed. A significant elevation in pulmonary artery pressure occurred during the heating phase, resulting in one pig death. In all other pigs, pulmonary artery pressure returned to physiologic values during the therapeutic phase. Arterial blood electrolytes were maintained without the need of a dialyzer. Major organ function was within normal parameters. The simplified vv-PISH circuit reliably delivered the hyperthermic dose with no need of dialysis.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Physiologic Response to a Simplified Venovenous Perfusion-Induced Systemic Hyperthermia System

Ballard-Croft

Wang²,

Jones³

et al. 2012

ASAIO Journal

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“…Whole body heat stress, including hot water immersion, induces changes in cardiovascular function [14] and immune function [15,16]. Perhaps it is for these reasons that whole body heat stress is used as treatment of cancer and chronic heart failure.…”

Section: Introductionmentioning

confidence: 99%

Head-out immersion in hot water increases serum BDNF in healthy males

Kojima

Nakamura

Banno

et al. 2017

International Journal of Hyperthermia

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“…Infrared radiation-induced whole body hyperthermia is non-invasive, but a long heating time (2–3 hours) is required, 7–9,24–25 which decreases the efficacy of cancer treatment. Heterogeneous heating also occurs, causing insufficient heat delivery to metastases which compromises therapeutic efficacy.…”

Section: Discussionmentioning

confidence: 99%

Resolution of Pulmonary Hypertension Complication During Venovenous Perfusion-Induced Systemic Hyperthermia Application

Ballard-Croft

Wang²,

Jones³

et al. 2013

ASAIO Journal

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We are developing a venovenous perfusion-induced systemic hyperthermia (vv-PISH) system for advanced cancer treatment. The vv-PISH system consistently delivered hyperthermia to adult healthy swine, but significant pulmonary hypertension developed during the heating phase. The goal of this study was to develop a method to prevent pulmonary hypertension. We hypothesized that pulmonary hypertension results from decreased priming solution air solubility which causes pulmonary gas embolism. Healthy adult sheep (n=3) were used to establish a standard vv-PISH sheep model without priming solution preheating. In subsequent sheep (n=7), the priming solution was preheated (42–46°C) and the hyperthermia circuit flushed with CO2. All sheep survived the experiment and achieved 2 hrs of 42 °C hyperthermia. In the group lacking priming solution preheating, significant pulmonary hypertension (35–44 mm Hg) developed. In the sheep with priming solution preheating, pulmonary artery pressure was very stable without pulmonary hypertension. Blood electrolytes were in physiological range, and complete blood counts were unaffected by hyperthermia. Blood chemistries revealed no significant liver or kidney damage. Our simple strategy of priming solution preheating completely resolved the problem of pulmonary hypertension as a milestone toward developing a safe and easy to use vv-PISH system for cancer treatment.

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Monitoring of whole-body hyperthermia with transesophageal echocardiography (TEE)

Abstract: Patients undergoing WBH showed typical signs of hyperdynamic circulation without impairment of left ventricle which could be monitored excellently by TEE. We recommend using TEE especially in patients with an increased cardiac risk.

Cited by 3 publications

References 26 publications

Physiologic Response to a Simplified Venovenous Perfusion-Induced Systemic Hyperthermia System

Physiologic Response to a Simplified Venovenous Perfusion-Induced Systemic Hyperthermia System

Head-out immersion in hot water increases serum BDNF in healthy males

Resolution of Pulmonary Hypertension Complication During Venovenous Perfusion-Induced Systemic Hyperthermia Application

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