“…Here, we are presenting a study about microbial resistance and resilience to different human activities in the second largest coastal ecosystem in the Pearl River Estuary (PRE) of China, where urbanization and agriculturalization (e.g., reclamation, and aquaculture) are recognized as the two major human disturbances driven by the rapid coastward migration of the population (Li, Bellerby, Craft, & Widney, ). In this region, the growth of coastal urban areas has been reported to be more than three times the national rate (McGranahan, Balk, & Anderson, ; Neumann, Vafeidis, Zimmermann, & Nicholls, ) with high population density of around 1,000–4,000 people/km 2 on average even in 2010 (Yu, Liu, & Zhang, ); this region is increasingly undergoing different environmental pressures related to human activities and disturbances. The primary objectives of this study were (a) to identify the changes in microbial communities within 1 year of different human disturbances in the field, the recovery in the structures of microbial communities and to identify the activities of these communities in microcosm experiments without human disturbances; (b) to evaluate the potential environmental factors driving the changes in microbial communities; and (c) to assess the importance of microbial abundance, diversity, and interactions to microbial functional resistance and resilience.…”