Monitoring Primary Effects of Pharmaceuticals in the Aquatic Environment with Mode of Action-Specific in Vitro Biotests

Triebskorn, Rita; Berg, Kristin; Ebert, Ina; Frey, Manfred; Jungmann, Dirk; Oehlmann, Jörg; Oetken, Matthias; Sacher, Frank; Scheurer, Marco; Schmieg, Hannah; Schwarz, Simon; Köhler, Heinz‐R.

doi:10.1021/acs.est.5b00162

Cited by 10 publications

(7 citation statements)

References 3 publications

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“…One striking result of the MEC database revealed that the concentrations of several pharmaceutical substances in the aquatic ecosystems are within the range known to cause acute or chronic toxicity. Although similar conclusions have been drawn in other publications , the global perspective of the established database adds a new dimension to this issue.…”

Section: Discussionsupporting

confidence: 85%

“…Despite these 2 examples, it must be noted that for most of the 631 different pharmaceutical substances detected in the environment, ecotoxicologically derived no‐effect concentrations have not yet been established , preventing a comprehensive environmental risk assessment. In the EU, an environmental risk assessment is mandatory for newly marketed drugs , but many commonly used drugs were introduced before this regulation came into force and thus have not been assessed .…”

Section: Discussionmentioning

confidence: 99%

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Pharmaceuticals in the environment—Global occurrences and perspectives

Beek

Weber

Bergmann

et al. 2016

Enviro Toxic and Chemistry

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1,086

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Pharmaceuticals are known to occur widely in the environment of industrialized countries. In developing countries, more monitoring results have recently become available, but a concise picture of measured environmental concentrations (MECs) is still elusive. Through a comprehensive literature review of 1016 original publications and 150 review articles, the authors collected MECs for human and veterinary pharmaceutical substances reported worldwide in surface water, groundwater, tap/drinking water, manure, soil, and other environmental matrices in a comprehensive database. Due to the heterogeneity of the data sources, a simplified data quality assessment was conducted. The database reveals that pharmaceuticals or their transformation products have been detected in the environment of 71 countries covering all continents. These countries were then grouped into the 5 regions recognized by the United Nations (UN). In total, 631 different pharmaceutical substances were found at MECs above the detection limit of the respective analytical methods employed, revealing distinct regional patterns. Sixteen substances were detected in each of the 5 UN regions. For example, the anti-inflammatory drug diclofenac has been detected in environmental matrices in 50 countries, and concentrations found in several locations exceeded predicted no-effect concentrations. Urban wastewater seems to be the dominant emission pathway for pharmaceuticals globally, although emissions from industrial production, hospitals, agriculture, and aquaculture are important locally. The authors conclude that pharmaceuticals are a global challenge calling for multistakeholder approaches to prevent, reduce, and manage their entry into and presence in the environment, such as those being discussed under the Strategic Approach to International Chemicals Management, a UN Environment Program. Environ Toxicol Chem 2016;35:823-835. # 2015 SETAC

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Pharmaceuticals in the environment—Global occurrences and perspectives

Beek

Weber

Bergmann

et al. 2016

Enviro Toxic and Chemistry

Self Cite

1,086

390

View full text Add to dashboard Cite

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“…The increased use of diverse classes of medicines is a growing requirement to ensure a better quality of life for the population (Basheer, 2018;Triebskorn et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Amino hydroxyapatite/chitosan hybrids reticulated with glutaraldehyde at different pH values and their use for diclofenac removal

Pereira

França

Araújo

et al. 2020

Carbohydrate Polymers

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“…As a result, such compounds are being reported all over the world, with environmental concentrations of pharmaceuticals covering orders of magnitude. − In addition, the long-term repercussions of pharmaceutical contamination are not yet fully understood due to the wide variety of prescription and nonprescription pharmaceuticals present in the environment. Nonetheless, it has been noted that, at trace concentrations, mixture effects can amplify the biological responses exhibited by nontarget organisms . For these reasons, the attention paid to environmental concentrations of pharmaceuticals will continue to grow.…”

Section: Introductionmentioning

confidence: 99%

“…Nonetheless, it has been noted that, at trace concentrations, mixture effects can amplify the biological responses exhibited by nontarget organisms. 6 For these reasons, the attention paid to environmental concentrations of pharmaceuticals will continue to grow.…”

Section: ■ Introductionmentioning

confidence: 99%

Rapid and Concomitant Analysis of Pharmaceuticals in Treated Wastewater by Coated Blade Spray Mass Spectrometry

Poole

Gómez‐Ríos

Boyacı

et al. 2017

Environ. Sci. Technol.

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The widespread use of pharmaceuticals in both human and animal populations, and the resultant contamination of surface waters from the outflow of water treatment facilities is an issue of growing concern. This has raised the need for analytical methods that can both perform rapid sample analysis and overcome the limitations of conventional analysis procedures, such as multistep workflows and tedious procedures. Coated blade spray (CBS) is a solid-phase microextraction based technique that enables the direct-to-mass-spectrometry analysis of extracted compounds via the use of limited organic solvent to desorb analytes and perform electrospray ionization. This paper documents how CBS can be applied for the concomitant tandem mass spectrometric (MS/MS) analysis of nine pharmaceuticals in treated wastewater. The total analysis times of less than 11 min provided limits of detection lower than 50 ng L for all target compounds in river water. The CBS methodology was then compared to a conventional solid-phase extraction technique for the analysis of the final effluent of six wastewater treatment facilities. The experimental results strongly suggest that CBS offers scientists a viable alternative method for analyzing water samples that is both rapid and relatively solvent-free.

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Monitoring Primary Effects of Pharmaceuticals in the Aquatic Environment with Mode of Action-Specific in Vitro Biotests

Cited by 10 publications

References 3 publications

Pharmaceuticals in the environment—Global occurrences and perspectives

Pharmaceuticals in the environment—Global occurrences and perspectives

Amino hydroxyapatite/chitosan hybrids reticulated with glutaraldehyde at different pH values and their use for diclofenac removal

Rapid and Concomitant Analysis of Pharmaceuticals in Treated Wastewater by Coated Blade Spray Mass Spectrometry

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