Monitoring Protocols for Cochlear Toxicity

Lord, Sherman G.

doi:10.1055/s-0039-1684042

Cited by 20 publications

(28 citation statements)

References 28 publications

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“…Another aspect to consider regarding the transient evoked otoacoustic emissions is that, even before those who acquired COVID-19 had their hearing loss evidenced in the PTA, there was a decrease in the size of the emission response when compared with healthy people. This finding is a characteristic revealed in this type of examination when the responses start to decrease or even be absent before changes take place in the PTA thresholds 13 .…”

Section: Literature Reviewmentioning

confidence: 61%

“…Hence, this type of response found in the otoacoustic emissions is commonly seen in people exposed to agents that temporarily or permanently damage the cochlear structures. Thus, it can help the physician to stop the person's exposure to such ototoxic agents whenever possible 13 . Therefore, the findings in this study can be associated in the long run with sensorineural hearing loss, which is commonly found in viral diseases 6 .…”

Section: Literature Reviewmentioning

confidence: 99%

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Audiological implications of COVID-19: an integrative literature review

Ribeiro

Silva

2021

Rev. CEFAC

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Purpose: to survey the national and international literature on the impacts of the coronavirus infection on the auditory system. Methods: an integrative review with search in the BIREME, PubMed, Scopus, and Web of Sciences databases. Inclusion criteria: articles in Portuguese and English whose subject was the coronavirus infection and its effects on the auditory system. Exclusion criteria: information from books and/or chapters, letters to editors, review articles, experience reports. The search strategy was based on the following combined descriptors, respectively in Portuguese and English: “Infecções por coronavírus”, “Audição”, “Perda auditiva”, “Coronavirus infections”, “Hearing”, “Hearing Loss”. Results: out of 43 articles found, two approached the issue. The first study assessed 20 patients that tested positive for COVID-19, though asymptomatic, who underwent pure-tone threshold audiometry and otoacoustic emissions. A significant increase in the auditory thresholds at high frequencies and a smaller response amplitude in the transient evoked otoacoustic emissions of those who tested positive for COVID-19 were observed when compared to that of controls. The second study reported the case of an asymptomatic 35-year-old COVID-19 female patient, who complained of otalgia and tinnitus, after being contaminated. The pure-tone threshold audiometry and tympanometry indicated mild unilateral (right ear) conductive hearing loss, with a type B tympanometric curve on that side. Conclusion: the studies included in this review showed different consequences of COVID-19 on hearing, with possible impairments on the sensory and mechanical structures of the auditory system. The knowledge of COVID-19 is limited, and further studies on its real impact on the auditory system are necessary.

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Section: Literature Reviewmentioning

confidence: 61%

Section: Literature Reviewmentioning

confidence: 99%

Audiological implications of COVID-19: an integrative literature review

Ribeiro

Silva

2021

Rev. CEFAC

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“…The limited collaborative work between audiologists and attending physicians (and the rest of the medical team involved in the management of these patients) to enable prevention of ototoxicity further negatively influences hearing conservation efforts for this already vulnerable population group. This prevents the execution of what Lord [27] refers to as another key purpose of ototoxicity monitoring, over and above provision of feedback to the attending physician about the effects the treatment is having on the auditory system; that of setting expectations for the patient and his/her family about the communication issues that may result from the drug therapy.…”

Section: Discussionmentioning

confidence: 99%

What Are the Current Audiological Practices for Ototoxicity Assessment and Management in the South African Healthcare Context?

Khoza-Shangase

Masondo

2020

IJERPH

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The study was an initial exploration of the current ototoxicity assessment and management practices by audiologists in South Africa. An exploratory survey research methodology through a cross-sectional research design was adopted where audiologists were recruited from professional associations’ databases in South Africa, using specific inclusion criteria. The study made use of an 18-item web-based survey guided by the Health Professions Council of South Africa (HPCSA) (2018) guidelines which were developed from reviewing international guidelines such as the American Speech-Language-Hearing Association (ASHA,1994) and the American Academy of Audiology (AAA, 2009). The study surveyed 31 audiologists from across the country. Data were analyzed through descriptive statistics. Findings implied significant gaps between knowledge and translation of this knowledge into practice. Over two thirds of the participants engage with ototoxicity monitoring and management, but the practices adopted by them do not align with international standards nor with the national HPCSA guidelines on assessment and management of patients on ototoxic medications. Most participants do not conduct baseline assessments, and the frequency of monitoring is irregular and reduced from the recommended; thus influencing ability for early detection and intervention of ototoxicity within this context. Non-standard assessment battery is used for assessment and monitoring, raising questions about the reliability and validity of the data used to make preventive treatment decisions. Lack of collaborative work between audiologists and the rest of the clinical team involved in the treatment of patients on ototoxic medications was found to be an important contributing factor to the less than optimal ototoxicity management practices. Of factors potentially influencing adherence to guidelines, the institution of employment, specifically employment in a tuberculosis hospital, seemed to have a positive influence, possibly due to the focused nature of the audiologists’ scope of practice there as well as availability of resources. The level of education appeared to have no influence. Current findings provide contextually relevant evidence on ototoxicity assessment and management within this context. They raise important implications for guidelines adherence and translating knowledge, policies and guidelines into practice, clinical assessment and management protocols followed, appropriate resource allocation per programme, as well as strategic planning for national ototoxicity assessment and management programmes in context. The findings also raise important implications for low- and middle-income countries, in terms of adopting international guidelines without considering context.

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“…According to clinical protocols and the recommendations of scientific societies, monitoring for early detection of ototoxicity allows treatment regimens to be changed and hence can minimize, or even prevent, ototoxicity leading to balance impairments and/or hearing loss (40,44,45). According to the American Academy of Audiology (AAA), sensorineural degradation and auditory damage can lead to permanent hearing loss and tinnitus.…”

Section: Ototoxicity As An Adverse Effect Of Drugsmentioning

confidence: 99%

Ototoxicity of Drugs Used in the Treatment of Covid-19

Skarżyńska¹,

Król²,

Czajka³

et al. 2020

J Hear Sci

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Background: Actual level of knowledge of treatment of COVID-19 disease caused by a type of coronavirus is that the disease cannot at present be cured by targeted therapy. Worldwide research is aiming to find a specific treatment, such as a vaccine or drug, for this type of coronavirus; this may help improve the situation, but it is highly expensive and time-consuming. The purpose of this paper is to review drug therapies approved in different parts of the world to treat COVID-19 and draw attention to ototoxicity as one of the adverse side-effects.Material and methods: Review of current literature was done in the scientific databases PubMed, ResearchGate, GoogleScholar, and Science-Direct. Studies were reviewed with reference to the inclusion criteria, then graded to assess the internal and external validity, leaving 50 studies for review.Results: According to scientific reports, possible antiviral pharmacological agents to treat COVID-19 consist of chloroquine, hydroxychloroquine, azitromycine, oseltamivir, and tocilizumab. In some cases, certain combinations may lead to additive ototoxicity as an adverse effect. Ototoxicity may be manifested by sensory and nervous hearing loss, tinnitus, imbalance, and cochlear-mandibular symptoms, which are sometimes temporary but sometimes permanent. Conclusion:Drug ototoxicity is well known as a cause of cochlear hearing loss, and so the use of new pharmacotherapy methods and drug combinations in the fight against the new coronavirus may have harmful effects. Ototoxicity needs to be taken into account.

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Monitoring Protocols for Cochlear Toxicity

Cited by 20 publications

References 28 publications

Audiological implications of COVID-19: an integrative literature review

Audiological implications of COVID-19: an integrative literature review

What Are the Current Audiological Practices for Ototoxicity Assessment and Management in the South African Healthcare Context?

Ototoxicity of Drugs Used in the Treatment of Covid-19

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