Monitoring Proton Therapy Through in-Beam PET: An Experimental Phantom Study

Topi, A.; Kraan, A.; Krzempek, Dawid; Krzempek, Katarzyna; Morrocchi, M.; Olko, P.; Sala, P.; Sportelli, Giancarlo; Rosso, V.; Muraro, S.; Battistoni, G.; Belcari, Nicola; Bisogni, Maria Giuseppina; Camarlinghi, N.; Guerra, Alberto Del; Ferrari, A.; Kopeć, Renata

doi:10.1109/trpms.2019.2924036

Cited by 13 publications

(11 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The calculated activity distribution predicted by FLUKA tools shows good agreement with experimental measurement for homogeneous phantom irradiated by 12 C and 16 O from GSI [10]. FLUKA is also employed in the development of detector system and reconstruction algorithm in DoPET project [11][12][13][14][15] and INSIDE project [16] for monitoring particle therapy. Simulation results from MCNP and GATE for in-beam PET in proton therapy supported the experimental measurement at the University of Texas MD Anderson Cancer Center [17].…”

Section: Jinst 17 T09006mentioning

confidence: 54%

See 1 more Smart Citation

Measured and GATE predicted PET-image-based activity range verification for carbon therapy: a phantom study

et al. 2022

View full text Add to dashboard Cite

In-beam PET is one of the imaging-based methods for monitoring carbon therapy by reconstruction of positron-emitters produced by incident particles. The accurate Monte Carlo simulation is necessary for range verification and therapeutic dose monitoring by means of the in-beam PET. GATE is capable of performing in-beam PET imaging but very few studies assess the accuracy of activity range measured from PET imaging with GATE simulated results. In this work, we present both experimental and GATE simulation studies of in-beam PET imaging of a phantom, which is irradiated by carbon ion beam, for range verification. The experiment data is acquired at Wuwei Heavy Ion Cancer Treatment Center in Gansu, China, with a dual-head plate PET prototype. The PET prototype consists of 2 panels, each arranged in 2 × 2 matrix. Each detector block is composed of 20 × 20 LYSO crystal array coupled with the position-sensitive photomultiplier tube (HAMAMATSU H8500). A homogeneous plastic phantom is irradiated with monoenergetic 131.05 MeV and 190.19 MeV 12C ion pencil beams. The irradiation and full response of PET prototype are simulated with GATE macros. A novel mathematical model is established, which is capable of calculating and revealing the variation of the positron activity. Our focus is on the reconstructed activity ranges obtained by the experimental measurement and GATE MC prediction combined with the positron activity distribution calculation mathematical model. Results show that the reconstructed activity distribution of experimental data and GATE MC prediction are in good agreement. The measured and simulated 1D activity peak and falling edge positions are within 1.0 mm in all cases. The 20%, 50% and 80% PET peak positions predicted by GATE are close to measurements. These results indicated that it is feasible to assess the accuracy of activity range measured from the dual-head plate PET system with the modeled GATE hadron-PET simulation.

show abstract

Section: Jinst 17 T09006mentioning

confidence: 54%

“…Only spill-off coincidences are used in image reconstruction. For the off-beam acquisition, the events are mainly from positron-emission nuclides like 11 C, 15 O, etc.…”

Section: Data Processing and Image Reconstructionmentioning

confidence: 99%

Measured and GATE predicted PET-image-based activity range verification for carbon therapy: a phantom study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…phantom size or irradiation plans. Recently, the mobile PET system DoPET, developed at the University of Pisa, Italy (Kraan et al 2019, Topi et al 2019, has been investigated for the application of range monitoring in proton therapy. Various phantoms were irradiated and PET signal was acquired immediately after the irradiation for five minutes, mimicking the in-room range monitoring approach.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of the J-PET to monitor range of therapeutic proton beams

Borys¹,

Brzeziński²,

Gajewski³

et al. 2023

Preprint

View full text Add to dashboard Cite

Objective: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J-PET) scanner for intra-treatment proton beam range monitoring.Approach: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J-PET scanner geometries (three dual-heads and three cylindrical). We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread-Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J-PET scanner prototype dedicated to the proton beam range assessment.Main results: The investigations indicate that the double-layer cylindrical and triple-layer double-head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10 −5 coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple-layer dual-head geometry.Significance: We performed simulation studies demonstrating that the feasibility of the J-PET detector for PET-based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre-clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and costeffectiveness, the double-layer cylindrical and triple-layer dual-head J-PET geometry configurations seem promising for the future clinical application. Experimental tests are needed to confirm these findings.

show abstract

“…This work was partially supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI (25242052, 19KK0280) The range verification for particle therapy is an active research area. In addition to PET-based methods using dual-head or partial ring geometries to allow the beam to pass through [12][13][14][15][16][17][18][19][20][21][22][23][24], collimators-based [25]- [28], timing-based [29], [30], and Compton camera techniques-based [31]- [35] methods targeting prompt gamma rays are being studied. Although these methods are classified as 2D or limited angle imaging, OpenPET has the potential to acquire highly accurate 3D images because of its full ring geometry.…”

Section: Introductionmentioning

confidence: 99%