Monitoring radiolabelled antacid preparations in the stomach

May, Hans; Wilson, Clive G.; Hardy, John G.

doi:10.1016/0378-5173(84)90159-5

Cited by 31 publications

(16 citation statements)

References 4 publications

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“…Jenkins et al studied emptying four hours after the meal27 and May et al 30 minutes after a liquid caloric meal. 28 In this study at all time intervals the emptying of magaldrate was significantly slower than that of Maalox. This might have been due to the special chemical structure of magaldrate, to its ability to adhere to the stomach wall, or to its different capacity for binding proteins.…”

Section: Discussionmentioning

confidence: 44%

“…But Maalox, with a t1/2 of 52 3 (5 2) minutes, shows a rate ofemptying similar to that found for a caloric liquid (Clinifeed ISO, Roussel Laboratories, Wembley Park, UK). 28 wllTc labelling of antacids containing AI(OH)3 and Mg(OH)2 is feasible, stability is satisfactory, and gastric emptying of labelled antacids can be monitored by scintigraphic techniques. Therefore, gastric emptying of labelled antacids may be useful in monitoring how long antacids remain in patients' stomachs.…”

Section: Discussionmentioning

confidence: 99%

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Gastric emptying of two radiolabelled antacids.

Monés

Carrió

Roca

et al. 1991

Gut

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The rate of gastric emptying of two antacids, magaldrate and Maalox, was investigated using scintigraphy. Successful labelling of the antacids was carried out with 'Tc. The stability of the ""Tc-labelled antacids was satisfactory and there was no difference in antacid capacity between the labelled and unlabelled antacids. The studies were carried out on 15 healthy male volunteers. After an eight hour fast each subject ingested a standardised meal of 95*7 MJ (400 kcal). One hour later 10 ml ofone ofthe two antacids previously labelled with "9mTc was administered. Serial detection by anterior and posterior projection ofthe amount ofantacid retained in the stomach was performed to determine gastric emptying of antacid. One week later the study was repeated under the same conditions with the other antacid also labelled with 9Tc. The mean (SD) percentages of antacid retained in the stomach fit a linear model with a tl/2 of 86.6 (15.3) minutes for magaldrate and 52.3 (5.2) minutes for Maalox (p<0-01). When the mean percentages of retention at six time intervals were compared for both antacids, it was found that Maalox emptied much faster (p<0.01 at 15 and 30 minutes, p<002 at 45, 60, 75, and 90 minutes).

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Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 99%

Gastric emptying of two radiolabelled antacids.

Monés

Carrió

Roca

et al. 1991

Gut

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“…Previous work in our laboratories has demonstrated that some alginate-bicarbonate anti-reflux formulations produce a floating layer in vivo (1). A recent study has demonstrated that a n alginate formulation containing antacid materials in addition to the bicarbonate required to elevate the 'raft' mixed and emptied with the food and did not show a prolonged gastric residence (2).…”

mentioning

confidence: 98%

An Investigation into the Floating Behaviour of a Pectin-Containing Anti-Reflux Formulation (FF5005) by Means of Gamma Scintigraphy

Washington

Wilson

Greaves

et al. 1988

Scandinavian Journal of Gastroenterology

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The gastric distribution and residence time of a new pectin-containing formulation, FF5005 (Farma Food A/S, Denmark), was investigated by using the technique of gamma scintigraphy in six healthy volunteers after administration with a radiolabelled meal. The formulation and test meal were radiolabelled with indium-113m and technetium-99m, respectively, and the formulation was administered to the subjects 30 min after the labelled meal. FF5005 was shown to float and form a discrete phase on top of the stomach contents and emptied from the stomach more slowly than the food (p less than 0.05, Wilcoxon signed rank test). The times taken for the formulation and test meal to half-empty from the stomach (T50) were 4.13 +/- 0.69 h (mean +/- SD) and 2.17 +/- 0.15 h (mean +/- SD), respectively. Greater than 50% of the formulation remained in the fundal region of the stomach for 3 h. FF5005 produced in vivo behaviour similar to that of established alginate-containing anti-reflux agents, and the pectin content of the formulation was shown to decrease the rate of emptying of the meal.

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“…5 Omeprazole is very effective in reducing gastric acidity, and is used for treating conditions such as reflux oesophagitis, peptic ulceration and Zollinger-Ellison syndrome. 3,7 A similar scintigraphic study using Liquid Gaviscon ® (10 ml) and tablet (one tablet) formulations showed raft formation in both fasting and fed volunteers for both product formulations. 8 Another scintigraphic study demonstrated that cimetidine pre-treatment did not affect the raft formation of Liquid Gaviscon ® .…”

Section: Introductionmentioning

confidence: 99%

“…3,4 Omeprazole, a substituted benzimidazole, is a potent long-acting inhibitor of gastric acid secretion that acts by inhibiting H + /K + adenosine triphosphatase, which is responsible for hydrogen ion secretion by the gastric parietal cell. 5 Omeprazole is very effective in reducing gastric acidity, and is used for treating conditions such as reflux oesophagitis, peptic ulceration and Zollinger-Ellison syndrome.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Omeprazole Pre-treatment on Rafts Formed by Reflux Suppressant Tablets Containing Alginate

2005

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Alginate-based reflux suppressant preparations provide symptom relief by forming a physical barrier on top of the stomach contents in the form of a neutral floating gel or raft. This study investigated whether reduced acidity in the stomach brought about by omeprazole pretreatment affected the formation and gastric residence time of alginate rafts. It was a balanced, cross-over study in 12 healthy non-patient volunteers following a single dose of two indium-111-labelled alginate tablets in the presence or absence of 3 days' pre-treatment with omeprazole. Raft formation and gastric residence, in the presence of a technetium-99m-labelled meal, were assessed by gamma scintigraphy for 3 h after alginate tablet administration. The relative raft-forming ability of alginate tablets after omeprazole compared with alginate tablets alone was 0.950 with 95% confidence intervals of 0.882 and 1.018. Pre-treatment and coadministration with omeprazole has no significant effect on the raft-forming ability of alginate tablets.

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Monitoring radiolabelled antacid preparations in the stomach

Cited by 31 publications

References 4 publications

Gastric emptying of two radiolabelled antacids.

Gastric emptying of two radiolabelled antacids.

An Investigation into the Floating Behaviour of a Pectin-Containing Anti-Reflux Formulation (FF5005) by Means of Gamma Scintigraphy

The Effect of Omeprazole Pre-treatment on Rafts Formed by Reflux Suppressant Tablets Containing Alginate

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