Morphological characteristics in river systems, including channel dimensions and river gradients, scale to drainage basin area, which provides the means for such elements to be predicted, measured and modeled. Moreover, recent studies interpret downstream changes in channel morphological and sedimentary characteristics to be the product of changing flow hydraulics as rivers transit from the normal flow to the backwater reach and approach the coastal ocean. This paper quantifies how large modern rivers undergo morphological and sedimentary transformations in response to normal flow to backwater transition. Morphologies adapting to such backwater hydraulic conditions is a potential for further investigation. With applications in modeling of modern river systems, this also provides the means for paleoenvironment reconstructions based on changing morphological characteristics since such quantitative framework is grounded by similar depositional processes. Building on previous studies, we construct river-long profiles, estimate backwater lengths, measure the ratio between channel-belt and channel widths (BChB/BCh), and measure the ratio between sand-rich to mud-dominated environments of deposition (S/M ratio) in five large modern river systems. We use results from >55,000 measurements of morphological and lithological characteristics from ~3,850 valley cross-sections over ~5,500 river kilometers to show that: (a) channel gradients decrease by ~30-50% as the channel goes through the normal flow to backwater transition, whereas (b) BChB/BCh decreases by >~60% and (c) S/M ratios decrease by ~35-90% within the upper backwater reach. These values further decrease in the lower backwater reach and approach unity (BChB/BCh = 1; S/M = 0) as the gradient reaches zero (sea level). Such systematic transformations in morphologic and sedimentary characteristics indicate they are both inherent and predictable, and can be used to interpret normal flow vs. backwater hydraulics in ancient fluvial deposits.