Monitoring serum gold values to improve chrysotherapy in rheumatoid arthritis.

Lorber, Arthur; Atkins, Christopher J.; Chang, Chia Chin; Lee, Y B; Starrs, Jane; Bovy, Ruth A.

doi:10.1136/ard.32.2.133

Cited by 65 publications

(28 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With regard to plasma gold levels, the authors feel compelled to state that the present data do not support (but d o not disprove) Lorber's concept of an "optimum gold level" (14). Our general conclusion in this regard agrees with that of Gottlieb (15).…”

Section: Discussioncontrasting

confidence: 72%

Chrysotherapy. A prospective study

Rothermich¹,

Philips²,

Bergen³

et al. 1976

Arthritis & Rheumatism

View full text Add to dashboard Cite

A 4-year prospective clinical study of chrysotherapy was designed to reexamine old beliefs and traditions, and to test potentially new approaches to chrysotherapy. The standard weekly dosage of 50 mg was compared to that based on 1 mg/kg body weight; no significant differences were found. The rapidly absorbed aqueous thiomalate was compared to the slowly absorbed oil repository thioglucose; the latter produced significantly less side effects and an appreciably higher percentage of improvement. Almost half (43%) of nonresponders on standard regimen had a satisfactory clinical response at higher dosage levels without increase in toxicity. Some of these findings vary so much with traditional beliefs and practices that the authors urge caution in their interpretation. But generally speaking these problems are technical and do not detract from the conviction that chryso-

show abstract

Section: Discussioncontrasting

confidence: 72%

Chrysotherapy. A prospective study

Rothermich¹,

Philips²,

Bergen³

et al. 1976

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…Enhanced efficacy has previously been reported in patients receiving parenteral chrysotherapy at an individualized dosage that would achieve serum gold concentrations >300 pg/lOO ml (3 pg/ml) during longterm therapy (10,12). In addition, patients who achieve high serum gold concentrations early in the course of treatment are reportedly more likely to manifest early improvement, i.e., before 20 weeks (10,18).…”

Section: Discussionmentioning

confidence: 95%

Lack of correlation between blood gold concentrations and clinical response in patients with definite or classic rheumatoid arthritis receiving auranofin or gold sodium thiomalate

Dahl¹,

Coleman²,

Williams³

et al. 1985

Arthritis & Rheumatism

View full text Add to dashboard Cite

We investigated the correlation between whole blood gold concentrations and clinical outcomes in 59 auranofin-treated patients and 51 gold sodium thiomalate-treated patients who completed a 21-week, placebocontrolled, multicenter parallel trial. Whole blood gold concentrations did not correlate with clinical outcome, as assessed by changes in joint tenderness, joint swelling, 'or Westergren erythrocyte sedimentation rate. They also did not correlate with toxic reactions necessitating withdrawal from the study.Chrysotherapy has been used for the symptomatic management of rheumatoid arthritis (RA) for more than 50 years and has been accepted as an effective treatment modality for the past 20 years (1,2). In general, two-thirds of RA patients who tolerate gold therapy respond favorably (3). The reasons for lack of response in one-third of the gold-treated patients and the wide variability in the degree of improvement observed in those patients who do respond remain unclear. Clinical features, such as age, gender, or race, and laboratory variables, such as presence of rheumatoid factor, magnitude of erythrocyte sedimentation From the Cooperative Systematic Studies of Rheumatic

show abstract

“…The effects of dosage, frequency and duration of gold administration were studied and relationships between blood gold concentrations and distribution of gold to plasma proteins, cellular blood components and other tissues were observed. After noting correlations between blood gold (as Au) levels and clinical response, adverse reactions and changes in specific laboratory parameters including the effects on immune function, this information was consolidated in the formulation of a therapy schedule (12). Gold administration monitored by blood gold level could then be individualized, adjusted and continued weekly to maintain a specified range of gold (as Au) concentration in the blood (300 to 700 pg/dl).…”

Section: Gold Administration -Blood Level Responsementioning

confidence: 99%