Monitoring temporal development and healing of diabetic foot ulceration using hyperspectral imaging

Yudovsky, Dmitry; Nouvong, Aksone; Schomacker, Kevin T.; Pilon, Laurent

doi:10.1002/jbio.201000117

Cited by 47 publications

(40 citation statements)

References 38 publications

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“…The general optical properties of this device have been previously described. 13 A narrowband-pass, liquid-crystal tunable filter (LCTF-10-20, CRI, Inc. Hopkinton, Massachusetts) was used to vary the wavelength of light passed on to a digital imaging detector (Guppy F-146B, Allied Vision Technologies, Stadtroda, Germany) to provide many images at 15 select wavelengths between 500 and 660 nm. Broadband light-emitting diodes were used to illuminate the sample (LUXEON, Philips Lumiled, Inc. San Jose, California).…”

Section: Hyperspectral Imagingmentioning

confidence: 99%

Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin

Chin

2012

J. Biomed. Opt

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Abstract. Studies examining acute oxygenation and perfusion changes in irradiated skin are limited. Hyperspectral imaging (HSI), a method of wide-field, diffuse reflectance spectroscopy, provides noninvasive, quantified measurements of cutaneous oxygenation and perfusion. This study examines whether HSI can assess acute changes in oxygenation and perfusion following irradiation. Skin on both flanks of nude mice (n ¼ 20) was exposed to 50 Gy of beta radiation from a strontium-90 source. Hyperspectral images were obtained before irradiation and on selected days for three weeks. Skin reaction assessment was performed concurrently with HSI. Desquamative injury formed in all irradiated areas. Skin reactions were first seen on day 7, with peak formation on day 14, and resolution beginning by day 21. HSI demonstrated increased tissue oxygenation on day 1 before cutaneous changes were observed (p < 0.001). Further increases over baseline were seen on day 14, but returned to baseline levels by day 21. For perfusion, similar increases were seen on days 1 and 14. Unlike tissue oxygenation, perfusion was decreased below baseline on day 21 (p < 0.002). HSI allows for complete visualization and quantification of tissue oxygenation and perfusion changes in irradiated skin, and may also allow prediction of acute skin reactions based on early changes seen after irradiation.

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Section: Hyperspectral Imagingmentioning

confidence: 99%

Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin

Chin

2012

J. Biomed. Opt

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“…HSI can be also used to measure the epidermal thickness for early prediction of diabetic foot ulcer formation as reported by Yudovsky et al (19) in 2011. The study was performed on the feet of two diabetic patients before, during, and after they developed foot ulcers.…”

Section: Assessment Of Diabetic Foot Ulcersmentioning

confidence: 97%

Hyperspectral Imaging in the Medical Field: Present and Future

Călin

Parasca

Săvăstru

et al. 2013

Applied Spectroscopy Reviews

186

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Hyperspectral imaging is an optical method that provides a large amount of information about the investigated object. Its medical applications are reviewed in this article, including tumor delimitation and identification, assessing tissue perfusion and its pathological conditions (including some complications like diabetic foot ulceration), making accurate surgical decisions, evaluating the health of dental structures, etc. Many of the articles show very promising results that required brief comments by the authors. It is clear that choosing the appropriate hyperspectral imaging system for each medical field, together with the most reliable hyperspectral image processing methods, are the main goals of future studies, before hyperspectral imaging becomes a widely applicable evaluation method in medicine. The authors try to answer some questions on this topic and set up some directions for future research.

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“…Their methods work well in predicting the ulcerations under abundant callus. 23,24 Some experts in diabetes still doubt whether the microvascular impairment is responsible for the diabetic feet ulcerations, 7 although they admit that revascularization can help to cure the microvascular abnormalities in diabetic foot. Therefore, hyperspectral imaging can be a promising, noninvasive diagnosis tool for diabetic feet ulceration, but still it needs more research and resources to prove that.…”

Section: Imaging Techniques On Diabetic Foot Ulceration Preventionmentioning

confidence: 99%

Towards surface analysis on diabetic feet soles to predict ulcerations using photometric stereo

Liu

Heijden

Netten

2012

Advanced Biomedical and Clinical Diagnostic Systems X

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Diabetic foot ulceration is a major complication for patients with diabetes mellitus. Approximately 15% to 25% of patients with Type I and Type II diabetes eventually develop feet ulcers. If not adequately treated, these ulcers may lead to foot infection, and ultimately to total (or partial) lower extremity amputation, which means a great loss in health-related quality of life. The incidence of foot ulcers may be prevented by early identification and subsequent treatment of pre-signs of ulceration, such as callus formation, redness, fissures, and blisters. Therefore, frequent examination of the feet is necessary, preferably on a daily basis. However, self-examination is difficult or impossible due to consequences of the diabetes. Moreover, frequent examination by health care professionals is costly and not feasible. The objective of our project is to develop an intelligent telemedicine monitoring system that can be deployed at the patients' home environment for frequent examination of patients feet, to timely detect pre-signs of ulceration. The current paper reports the preliminary results of an implementation of a photometric stereo imaging system to detect 3D geometric abnormalities of the skin surfaces of foot soles. Using a flexible experimental setup, the system parameters such as number and positions of the illuminators have been selected so as to optimize the performance with respect to reconstructed surface. The system has been applied to a dummy foot sole. Finally, the curvature on the resulting 3D topography of the foot sole is implemented to show the feasibility of detecting the pre-signs of ulceration using photometric stereo imaging. The obtained results indicate clinical potential of this technology for detecting the pre-signs of ulceration on diabetic feet soles.

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Monitoring temporal development and healing of diabetic foot ulceration using hyperspectral imaging

Cited by 47 publications

References 38 publications

Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin

Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin

Hyperspectral Imaging in the Medical Field: Present and Future

Towards surface analysis on diabetic feet soles to predict ulcerations using photometric stereo

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