Monitoring the acute response in severe hypersensitivity reactions to drugs

Abstract

The use of a combination of several early biomarkers, although not sufficiently sensitive or specific on its own when used alone, could increase the diagnostic and prognostic utility for the prediction of severe ADRs.

Drug reaction with eosinophilia and systemic symptoms from ceftriaxone confirmed by positive patch test: An immunohistochemical study

“…Moreover, the increase in soluble FASL has been recently identified as an early biomarker of DRESS progression to TEN. 10 In this first reported case of DRESS syndrome induced by ceftriaxone, we confirmed the diagnostic role of PT. Moreover, immunohistochemical data showed similar distribution of a panel of cytokines both in skin lesions and in biopsy of patch test and documented the coexistence of type IVb and IVc hypersensitivity.…”

Monocytes are involved in the balance between regulatory T cells and Th17 cells in severe drug eruptions

“…Our findings indicate that anti‐IL‐6 mAb may have a beneficial effect in patients with DiHS/DRESS at the resolution stage, in which impaired Tregs and increased Th17 cells play a key role in sustaining the inflammatory responses, although we have to consider the potential side effects. Consistent with this view, our ongoing studies on serum cytokine levels at the initial presentation of severe drug eruption show that the IL‐6 levels are reliable biomarkers predictive of the progression to SJS/TEN …”

“…Consistent with this view, our ongoing studies on serum cytokine levels at the initial presentation of severe drug eruption show that the IL-6 levels are reliable biomarkers predictive of the progression to SJS/TEN. 34 Corticosteroids have been shown to reduce various proinflammatory cytokine levels and expand Tregs. 35,36 We therefore evalu- In conclusion, we found that MOs from the acute stage of DiHS/ DRESS are more prone to expand iTregs due to the relative increase in cMOs with the potent ability to expand iTregs to cMOs, whereas those at the resolution stage are likely to induce Th17 cell development due to reappearance of pMOs preferentially producing IL-6 ( Figure S6) that may be different from the original population.…”

Hematologic Features of Children and Adolescent Patients with Acute Hypersensitivity Reactions on Drugs and Food

“…On the contrary, proinflammatory cytokines play a great role in the development of drug and food hypersensitivity reactions, as well as anemia of chronic disease [6][7][8]. So, theoretically, we found the hematological features in the patients with hypersensitivity reactions.…”