Monitoring the genotoxic effects of radiosynovectomy with Re‐186 in paediatric age group undergoing therapy for haemophilic synovitis

Türkmen, Cüneyt; Öztürk, Şükrü; Ünal, Sabri; Zülfikar, Bulent; Taşer, Ömer; Şanlı, Yasemin; Çefle, Kıvanç; Kılıçoğlu, Önder; Palandüz, Şükrü; Özel, Sevda

doi:10.1111/j.1365-2516.2006.01406.x

Cited by 30 publications

(26 citation statements)

References 25 publications

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“…Turkmen et al. [17] reported a safety study in 20 boys with haemophilia who had undergone RS with Re 186 . In this study, cytogenetic analyses were evaluated and there were no significant differences between baseline and the day 90 control.…”

Section: Discussıonmentioning

confidence: 99%

Radioisotope synovectomy with rhenium¹⁸⁶in haemophilic synovitis for elbows, ankles and shoulders

Kavaklı

Aydoğdu²,

Taner³

et al. 2008

Haemophilia

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We have performed 221 radioisotope synovectomy (RS) in more than 150 children and young adults with haemophilia, age ranging 3-30 years (mean 15) in Ege Hemophilia Center, Izmir, Turkey for last 7 years. We always preferred to use Yttrium 90 (Y(90)) for knees; however, since 2005, we started using rhenium 186 (Re(186)) for medium-sized joints with respect to safety. In this article, we have evaluated long-term experience ranging from 6 months to 3 years (mean 18 months) with Re(186) for elbows (n = 35), ankles (n = 26) and shoulders (n = 2) in total of 63 RS procedures for 49 patients. Their age range was 3-30 years and mean age was 15.5. Two mCi of Re(186) intra-articularly injected for treating target joints and chronical synovitis. After RS, joint bleedings were decreased for all patients. The best results were obtained for all joints in patients with grade-II synovitis as like earlier experience with Y(90). Excellent rates (no bleeding) were observed in grade-II synovitis in 81% and 46% for elbows vs. 86% and 57% for ankles after 6 months and after 1 year follow-up of patients, respectively. In grade-III synovitis, excellent rates were 53% and 25% for elbows and 44% and 29% for ankles, respectively. In five joints for five patients, repeated injections were needed for better outcome. No adverse events such as radioisotope leakage, local inflamatory reactions or malignancy development were observed during and after RS. For medium-sized joints, RS with Re(186) seems to be either effective or safe treatment method. Our results confirm those previously published by others on the value of Re(186) synoviorthesis in medium-sized joints in haemophilia patients. After this experience, we changed our protocol and we use Re(186) for all medium-sized joints for treating chronical synovitis.

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Section: Discussıonmentioning

confidence: 99%

Radioisotope synovectomy with rhenium¹⁸⁶in haemophilic synovitis for elbows, ankles and shoulders

Kavaklı

Aydoğdu²,

Taner³

et al. 2008

Haemophilia

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“…However, as outlined above some patients who still had CBs even after 1 year of observation and de novo chromosomal changes after radioisotopic exposure may be accepted as warning signals for young population. Turkmen et al [17] reported a safety study in 20 boys with hemophilia who had undergone RS with 186 Re. They used micronucleus assay as in our study to evaluate DNA damage in these patients.…”

Section: Discussionmentioning

confidence: 98%

Micronucleus evaluation for determining the chromosomal breakages after radionuclide synovectomy in patients with hemophilia

et al. 2011

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“…Regarding the chromosomal changes after RS, several authors have shown that genotoxic radiation doses delivered to the peripheral lymphocytes are not statistically significant (17,18,19,20,21). However, transient increase in micronuclei of peripheral lymphocytes may be expected soon after Y-90 therapy which disappeared at 90 th .…”

Section: Introductionmentioning

confidence: 99%

“…However, transient increase in micronuclei of peripheral lymphocytes may be expected soon after Y-90 therapy which disappeared at 90 th . day (20). …”

Section: Introductionmentioning

confidence: 99%

Radiosynovectomy in Hemophilic Synovitis

Özcan¹

2014

Mirt

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Radisosynovectomy (RS) is a local form of radionuclide therapy used in various forms of arthritis characterized by synovitis. In hemophilic arthropathy, RS provides removal of inflamed synovium and prevents further joint damage. This review focuses on the practical aspects of radionuclide synovectomy in hemophilic patients and describes the issues both related to the methodology and post-therapeutic follow-up.Conflict of interest:None declared.

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Monitoring the genotoxic effects of radiosynovectomy with Re‐186 in paediatric age group undergoing therapy for haemophilic synovitis

Abstract: The major finding of this study with relatively small sample is that, radiosynovectomy with Re-186 does not seem to induce early genotoxic effects on the peripheral blood lymphocytes in paediatric age group.

Cited by 30 publications

References 25 publications

Radioisotope synovectomy with rhenium¹⁸⁶in haemophilic synovitis for elbows, ankles and shoulders

Radioisotope synovectomy with rhenium¹⁸⁶in haemophilic synovitis for elbows, ankles and shoulders

Micronucleus evaluation for determining the chromosomal breakages after radionuclide synovectomy in patients with hemophilia

Radiosynovectomy in Hemophilic Synovitis

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Monitoring the genotoxic effects of radiosynovectomy with Re‐186 in paediatric age group undergoing therapy for haemophilic synovitis

Abstract: The major finding of this study with relatively small sample is that, radiosynovectomy with Re-186 does not seem to induce early genotoxic effects on the peripheral blood lymphocytes in paediatric age group.

Cited by 30 publications

References 25 publications

Radioisotope synovectomy with rhenium186in haemophilic synovitis for elbows, ankles and shoulders

Radioisotope synovectomy with rhenium186in haemophilic synovitis for elbows, ankles and shoulders

Micronucleus evaluation for determining the chromosomal breakages after radionuclide synovectomy in patients with hemophilia

Radiosynovectomy in Hemophilic Synovitis

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Product

Resources

About

Radioisotope synovectomy with rhenium¹⁸⁶in haemophilic synovitis for elbows, ankles and shoulders

Radioisotope synovectomy with rhenium¹⁸⁶in haemophilic synovitis for elbows, ankles and shoulders