Monitoring the impact of a mebendazole mass drug administration initiative for soil-transmitted helminthiasis (STH) control in the Western Visayas Region of the Philippines from 2007 through 2011

Sanza, Megan; Totañes, Francis Isidore G.; Chua, Paul Lester; Belizario, Vicente Y.

doi:10.1016/j.actatropica.2013.03.017

Cited by 9 publications

(9 citation statements)

References 19 publications

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“…However, these data constitute the most up to date information on the prevalence of STH infections in the Philippines. The most recent studies only cover the prevalence of STH infections on a regional level [ 15 , 18 , 24 , 25 ], but provide sufficient evidence to suggest that the national level of prevalence is still similar to that of the 2005–2007 survey. Therefore, we anticipate our survey data is still relevant.…”

Section: Discussionmentioning

confidence: 99%

“…Targeting treatment, prevention and control activities to communities with high-intensity STH infections, or co-infections, could lead to a more efficient reduction in transmission and severe STH-related morbidity compared to targeting treatment based only on prevalence of single infections [ 21 – 23 ]. Despite intervention schemes being implemented to reduce morbidity attributable to STH infections in the Philippines [ 11 , 17 ], persistently high prevalence rates among school-aged children continue to be recorded across the country [ 15 , 18 , 24 , 25 ]. Available evidence suggests that indicators based on co-infections and infection intensities, which are linked to higher degrees of morbidity, are useful for estimating disease burden.…”

Section: Introductionmentioning

confidence: 99%

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Spatial distribution and populations at risk of A. lumbricoides and T. trichiura co-infections and infection intensity classes: an ecological study

et al. 2018

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BackgroundSoil-transmitted helminth (STH) infections are highly prevalent in the Philippines. Mapping the prevalence and high-intensity of STH co-infections can help guide targeted intervention programmes to reduce morbidity, especially among vulnerable school-aged children. In this study, we aimed to predict the spatial distribution of the prevalence of Ascaris lumbricoides and Trichuris trichiura co-infection and infection intensity classes in the Philippines to identify populations most in need of interventions.MethodsData on STH infections from 29,919 individuals during the nationwide parasitological survey in 2005 to 2007 were included in the analysis. To geographically predict the prevalence of A. lumbricoides and T. trichiura co-infections and infection intensity classes, Bayesian multinomial geostatistical models were built including age, sex, environmental variables and a geostatistical random effect. The number of individuals co-infected and belonging to each of the infection intensity classes in 2017 was forecast by combining our predictive prevalence maps with population density maps.ResultsOur models showed that school-aged children (5–19 years) are most at risk of A. lumbricoides and T. trichiura co-infections and of moderate/high infection intensity compared to other age groups. We identified target provinces where the likelihood of STH-associated morbidity was highest: Luzon (Bulacan, Benguet, Cavite, Sorsogon, Metropolitan Manila, Pampanga and Rizal), the Visayas (Cebu, Iloilo, Leyte and Negros Occidental), and in Mindanao (Agusan Del Norte, Davao Del Sur, Davao Oriental, Lanao Del Sur, Maguindanao, Misamis Oriental, Sulu and Zamboanga Del Sur). Luzon had the highest estimated number of school-aged children with A. lumbricoides and T. trichiura co-infections (estimated total 89,400), followed by the Visayas (38,300) and Mindanao (20,200).ConclusionsOur study provided epidemiological evidence to highlight national priority areas for controlling co-infections and high intensity infections in the Philippines. Our maps could assist more geographically targeted interventions to reduce the risk of STH-associated morbidity in the Philippines.Electronic supplementary materialThe online version of this article (10.1186/s13071-018-3107-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spatial distribution and populations at risk of A. lumbricoides and T. trichiura co-infections and infection intensity classes: an ecological study

et al. 2018

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“…In some cases this is due to poor community involvement, but also because of concerns with possible side effects of the drugs. In the IHCP school deworming program, there was an increase in STH in at least one city (46.05% in 2007 to 56.60% in 2011), and the overall prevalence remained high at 45% as of 2011 [ 160 ]. Assuming 100% coverage, the problem of STH will still exist, since re-infection can occur very quickly after treatment, and STH eggs/larvae can live in the environment for several weeks to months, remaining viable for infection.…”

Section: Treatment and Mass Drug Administration (Mda) Of Sth Infementioning

confidence: 99%

Soil-Transmitted Helminths in Tropical Australia and Asia

et al. 2017

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Soil-transmitted helminths (STH) infect 2 billion people worldwide including significant numbers in South-East Asia (SEA). In Australia, STH are of less concern; however, indigenous communities are endemic for STH, including Strongyloides stercoralis, as well as for serious clinical infections due to other helminths such as Toxocara spp. The zoonotic hookworm Ancylostoma ceylanicum is also present in Australia and SEA, and may contribute to human infections particularly among pet owners. High human immigration rates to Australia from SEA, which is highly endemic for STH Strongyloides and Toxocara, has resulted in a high prevalence of these helminthic infections in immigrant communities, particularly since such individuals are not screened for worm infections upon entry. In this review, we consider the current state of STH infections in Australia and SEA.

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“…Once present, parasitic infections can promote the further loss of nutrients, leading to reduced growth and poor nutritional status as part of a vicious cycle [ 18 ]. Children aged 5–14 years suffer from the highest burden of infectious disease [ 19 ], partly due to their increased behavioural risk, frequent outdoor exposure, and poor personal hygiene [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Poverty, Dietary Intake, Intestinal Parasites, and Nutritional Status among School-Age Children in the Rural Philippines

et al. 2017

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Intestinal helminths are endemic throughout the Philippines; however, there is limited evidence with respect to their prevalence, intensity, and impact on children’s nutritional status. A cross-sectional survey was carried out on 693 children from five rural villages in Northern Samar, the Philippines. Data on dietary intake, nutritional status, and intestinal parasites were collected. Infection with Schistosoma japonicum, Ascaris lumbricoides, Trichuris trichiura, and hookworm was evident in 20.1, 54.4, 71.4, and 25.3% of the children. The majority (84.7%) was infected with one or more helminth species, with about one-quarter of the sample (24.7%) infected with three or more. About half (49.2%, n = 341) of the children were stunted and 27.8% (n = 193) were wasted. A lower prevalence of normal height-for-age (48.3%) appeared in those with polyparasitism, while the prevalence of stunted children increased with infection (46.7% monoparasitism and 51.7% polyparasitism). There was a decreasing trend between infection intensity and the mean values of HAZ and BAZ identified for T. trichiura or hookworm infections. Stunted children were more likely to be male (AOR = 1.58; 95% CI: 1.05–2.39; p = 0.028), older in age (10–14 years) (AOR = 1.93; 95% CI: 1.29–2.88; p = 0.001), and living in poorer households with palm leaves/nipa roof (AOR = 1.85; 95% CI: 1.14–3.01; p = 0.013). Intestinal parasitic treatment needs to be combined with nutrient supplements and health education in order to interrupt the parasite life cycle and achieve sustainable control.

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Monitoring the impact of a mebendazole mass drug administration initiative for soil-transmitted helminthiasis (STH) control in the Western Visayas Region of the Philippines from 2007 through 2011

Cited by 9 publications

References 19 publications

Spatial distribution and populations at risk of A. lumbricoides and T. trichiura co-infections and infection intensity classes: an ecological study

Spatial distribution and populations at risk of A. lumbricoides and T. trichiura co-infections and infection intensity classes: an ecological study

Soil-Transmitted Helminths in Tropical Australia and Asia

Poverty, Dietary Intake, Intestinal Parasites, and Nutritional Status among School-Age Children in the Rural Philippines

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