Monitoring the menstrual cycle: Comparison of urinary and serum reproductive hormones referenced to true ovulation

Roos, J; Johnson, Sarah; Weddell, Sarah; Godehardt, Erhard; Schiffner, Julia; Freundl, Günter; Gnoth, Christian

doi:10.3109/13625187.2015.1048331

Cited by 95 publications

(87 citation statements)

References 24 publications

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“…Such methods include the measurement of pituitary or ovarian hormones in the blood, urine or saliva, and the assessment of clinical symptoms including menstrual cycle length or basal body temperature (BBT) (Campbell and Rockett, 2006; Lynch et al , 2006). In line with these standards, the studies were justified in their common use of serum progesterone or urinary PDG (Table 2, Column 2); both have been validated as reliable and interchangeable markers of ovulation in women with regular menstrual cycles (Roos et al , 2015). A sustained elevation in either biochemical marker is considered sufficient evidence of luteal activity and can be detected throughout the luteal phase to the end of the cycle (Roos et al , 2015).…”

Section: Inconsistencies In the Methods Used To Measure Ovulatory Statusmentioning

confidence: 99%

“…In line with these standards, the studies were justified in their common use of serum progesterone or urinary PDG (Table 2, Column 2); both have been validated as reliable and interchangeable markers of ovulation in women with regular menstrual cycles (Roos et al , 2015). A sustained elevation in either biochemical marker is considered sufficient evidence of luteal activity and can be detected throughout the luteal phase to the end of the cycle (Roos et al , 2015). …”

Section: Inconsistencies In the Methods Used To Measure Ovulatory Statusmentioning

confidence: 99%

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Impact of hypocaloric dietary intervention on ovulation in obese women with PCOS

Jarrett¹,

Lujan²

2017

Reproduction

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Polycystic ovary syndrome (PCOS) is a common cause of ovulatory dysfunction affecting women of reproductive age. Obesity and insulin resistance are thought to potentiate disruptions in antral follicle development that result in chronic anovulation, and as such, have become important therapeutic targets of dietary interventions aimed at weight loss. Caloric restriction has been shown to promote sporadic ovulation in obese women with PCOS, but improvements have occurred across a wide range of patients and little has been garnered about the factors that distinguish responders from non-responders. Further, few studies have evaluated the likelihood for modest weight loss to restore normal ovulatory cyclicity in PCOS. Consensus regarding the impact of dietary intervention on ovulation has been limited by variability in the measures used to characterize and report ovulatory status across studies. In response, this review provides an assessment of the evidence surrounding the effectiveness of hypocaloric dietary intervention to normalize ovulatory function in PCOS. The impact of physiological vs methodological factors on the evaluation of ovulatory status is discussed, and recommendations to strengthen future studies in this area are provided. Ultimately, further research is needed to understand the optimal dietary or lifestyle approaches that promote ovulation and sustained improvements in reproductive function in PCOS.Reproduction (2017) 153 R15-R27

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Section: Inconsistencies In the Methods Used To Measure Ovulatory Statusmentioning

confidence: 99%

Section: Inconsistencies In the Methods Used To Measure Ovulatory Statusmentioning

confidence: 99%

Impact of hypocaloric dietary intervention on ovulation in obese women with PCOS

Jarrett¹,

Lujan²

2017

Reproduction

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“…The referent we used in this study was the urine LH surge plus one day, as assessed by a blinded version of the Clearblue Fertility Monitor. While this referent has been found to have high accuracy for the timing of ovulation, it has some variability in relation to ovulation assessed by follicular ultrasound or other hormonal markers (such as rise in progesterone) . Based on prior studies that have used an ultrasound referent, we believe that the agreement between cervical mucus Peak Day and ovulation assessed by urine LH surge plus one day would be similar to the agreement between cervical mucus Peak Day and ovulation assessed by follicular ultrasound …”

Section: Commentmentioning

confidence: 87%

“…14,15 Thus, urine LH is generally considered an accurate and appropriate marker for ovulation when ultrasound is not available. [16][17][18] Woman's observations of their own cervical mucus (cervical fluid) constitute another biomarker for ovulation, which has minimal cost, can be used many settings, and has been used to develop and validate protocols for identifying ovulation. 11,[19][20][21][22] Based on cervical mucus observations, the estimated day of ovulation, or "Peak Day", is defined as the "last day" when women observe cervical mucus present which is clear, stretchy, or has a slippery or lubricative sensation at the vulva, with some slight variations of definition for different investigators.…”

Section: Backg Rou N Dmentioning

confidence: 99%

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Comparison of woman‐picked, expert‐picked, and computer‐picked Peak Day of cervical mucus with blinded urine luteinising hormone surge for concurrent identification of ovulation

Stanford

Schliep

Chang

et al. 2020

Paediatric Perinatal Epid

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Background Previous research has demonstrated that women instructed in fertility awareness methods can identify the Peak Day of cervical mucus discharge for each menstrual cycle, and the Peak Day has high agreement with other indicators of the day of ovulation. However, previous studies enrolled experienced users of fertility awareness methods or were not fully blinded. Objective To assess the agreement between cervical mucus Peak Day identified by fertile women without prior experience on assessing cervical mucus discharge with the estimated day of ovulation (1 day after urine luteinising hormone surge). Methods This study is a secondary analysis of data from a randomised trial of the Creighton Model FertilityCareTM System (CrM), conducted 2003‐2006, for women trying to conceive. Women who had no prior experience tracking cervical mucus recorded vulvar observations daily using a standardised assessment of mucus characteristics for up to seven menstrual cycles. Four approaches were used to identify the Peak Day. The referent day was defined as one day after the first identified day of luteinising hormone (LH) surge in the urine, assessed blindly. The percentage of agreement between the Peak Day and the referent day of ovulation was calculated. Results Fifty‐seven women with 187 complete cycles were included. A Peak Day was identified in 117 (63%) cycles by women, 185 (99%) cycles by experts, and 187 (100%) by computer algorithm. The woman‐picked Peak Day was the same as the referent day in 25% of 117 cycles, within ±1 day in 58% of cycles, ±2 days in 84%, ±3 days in 87%, and ±4 days in 92%. The ±1 day and ± 4 days' agreement was 50% and 90% for the expert‐picked and 47% and 87% for the computer‐picked Peak Day, respectively. Conclusions Women's daily tracking of cervical mucus is a low‐cost alternative for identifying the estimated day of ovulation.

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Timed intercourse for couples trying to conceive

Gibbons,

Reavey,

Georgiou

et al. 2023

Cochrane Database of Systematic Reviews

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Monitoring the menstrual cycle: Comparison of urinary and serum reproductive hormones referenced to true ovulation

Cited by 95 publications

References 24 publications

Impact of hypocaloric dietary intervention on ovulation in obese women with PCOS

Impact of hypocaloric dietary intervention on ovulation in obese women with PCOS

Comparison of woman‐picked, expert‐picked, and computer‐picked Peak Day of cervical mucus with blinded urine luteinising hormone surge for concurrent identification of ovulation

Timed intercourse for couples trying to conceive

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