Monitoring thermo-reversible dehydration of the pluronic microenvironment using 4-chloro-1-naphthol as an ESPT fluorescent molecular probe

Sarkar, Ivy

doi:10.1039/c5nj03354c

Cited by 3 publications

(2 citation statements)

References 48 publications

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“…10 Roy et al have studied the efficiency of fluorescence resonance energy transfer between coumarin 153 and rhodamine 6G in pluronic f127 medium. 11 Sarkar has monitored the thermo-reversible dehydration of pluronic microenvironment using 4-chloro-1-naphthol as a fluorescent molecular probe 12 Khateb et al have reported the ocular drug delivery application of pluronic F127 along with pluronic F68. 13 Devi et al have developed the drug delivery and gene therapy utility of different poloxamers.…”

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confidence: 99%

Molecular Level Understanding of Sodium Dodecyl Sulfate (SDS) Induced Sol–Gel Transition of Pluronic F127 Using Fisetin as a Fluorescent Molecular Probe

Mishra

Swain

2017

J. Phys. Chem. B

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The thermoreversible sol-gel transition of pluronic F127 is markedly altered even with addition of submicellar concentration of sodium dodecyl sulfate (SDS) surfactant. Multiple fluorescence parameters like fluorescence intensity, fluorescence anisotropy and fluorescence lifetime of both the prototropic forms (anion (A*) and phototautomer FT*) of the photoprototropic fluorescent probe fisetin has been efficiently used to understand the molecular level properties like polarity and microviscosity of the PF127-SDS system as a function of temperature. The SDS-induced increase in the interfacial hydrophobicity level is seen to affect the sol-gel phase transition of PF127 (21-18 °C). The E(30) polarity parameter value of anionic emission of fisetin suggests that there is a considerable decrease in the polarity of the PF127 medium with increase in temperature and with the addition of SDS. The microviscosity progressively increases from ∼5 mPa s (sol state, 10 °C) to ∼22.01 mPa s (gel state 35 °C) in aqueous solution of PF127. The variation in microviscosity with addition of SDS in PF127-SDS mixed system is significant in sol phase whereas in gel phase this variation is significantly less. Temperature dependent fluorescence lifetime of FT* indicates that there is heterogeneity in distribution of fisetin molecules at different domains of PF127. This work also show-cases the sensitivity of fisetin toward change in polarity and change in sol-gel transition temperature of copolymer PF127 with variation in temperature (both forward and reverse directions) and SDS.

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confidence: 99%

Molecular Level Understanding of Sodium Dodecyl Sulfate (SDS) Induced Sol–Gel Transition of Pluronic F127 Using Fisetin as a Fluorescent Molecular Probe

Mishra

Swain

2017

J. Phys. Chem. B

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“…It is nontoxic, nonionic and amphiphilic . It is a thermoreversible gel having transition temperature of 20–22 °C . The process of gelation is both concentration and temperature dependent .…”

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confidence: 99%

Estimation of Micropolarity and Microviscosity of Pluronic F127–Surfactant Mixed Systems Using Fisetin as a Fluorescent Molecular Probe

Mishra

2019

ChemistrySelect

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Surfactant induced changes in the transition temperature of Pluronic F127 have been studied using differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and fluorescence spectroscopy. The analysis shows that ionic surfactants (cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS)) significantly alter the transition temperature of PF127, whereas the effect of a nonionic surfactant (Tween20) is not significant. The sol-gel transition temperature decreases from PF127 (22°C) to PF127 + TW20 (21°C) to PF127 + CTAB (18°C), whereas there is no sol-gel transition temperature observed for PF127 + SDS. Using the anionic emission and fluorescence anisotropy value of fisetin, the local polarity and microviscosity in the immediate neigh-bourhood of fisetin in pluronic-surfactant systems have been estimated. Rotational correlation time along with the timeresolved fluorescence anisotropy study gives additional information about the variation in medium microviscosity (PF127) with temperature in the absence and presence of surfactants. Variation in both polarity and microviscosity of the PF127surfactant mixed systems follows a reverse trend at sol and gel phases. Fluorescence lifetime studies indicate that fisetin molecules distribute in the different microdomains of PF127surfactant mixed systems. The local environmental heterogeneity at different microdomains of PF127-surfactant mixed system is confirmed from lifetime distribution analysis of fisetin FT* emission.[a] J.

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A dual experimental–theoretical perspective on ESPT photoacids and their challenges ahead

Sülzner,

Jung,

Nuernberger

2025

Chem. Sci.

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Monitoring thermo-reversible dehydration of the pluronic microenvironment using 4-chloro-1-naphthol as an ESPT fluorescent molecular probe

Abstract: An ESPT fluorescent molecular probe, 4-chloro-1-naphthol, has been employed to study the thermo-reversible sol–gel transition, dehydration and micro-polarity of pluronics.

Cited by 3 publications

References 48 publications

Molecular Level Understanding of Sodium Dodecyl Sulfate (SDS) Induced Sol–Gel Transition of Pluronic F127 Using Fisetin as a Fluorescent Molecular Probe

Molecular Level Understanding of Sodium Dodecyl Sulfate (SDS) Induced Sol–Gel Transition of Pluronic F127 Using Fisetin as a Fluorescent Molecular Probe

Estimation of Micropolarity and Microviscosity of Pluronic F127–Surfactant Mixed Systems Using Fisetin as a Fluorescent Molecular Probe

A dual experimental–theoretical perspective on ESPT photoacids and their challenges ahead

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