The mining process in deep mines occurs at elevated temperatures and thus is significantly jeopardized by the thermal damage. In this study, the main factors causing high-temperatures under particular mining geological and prevailing conditions of coal mine production, namely for the Longgu Coal Mine (LCM) in Shandong Province of China, were specified and analyzed in detail. This included exothermic heat from the surrounding rock of an underground roadway, inflow of high-temperature water, seasonal temperature rise, mechanical and electrical equipment operation, and airflow compression in the mine. The integrated artificial cooling mode was implemented on the basis of the original normal ventilation and cooling facilities of the LCM, which involved cooling by mobile refrigeration units, water source heat pump refrigeration units, and a ground centralized ice-cooling radiation system, as well as the underground centralized cooling system provided by Wärme-Austausch-Technik (WAT) GmbH. Eventually, a comprehensive set of measures for the overall control and reduction of high-temperature-induced damage was realized, which ensured more effective cooling of the LCM. Thus, the average temperature of the main operation sites was reduced by 8 K, while that of the underground working faces was maintained at 299.15 K. These measures also resulted in excellent technical and economic benefits: the total three-year increase in revenue and savings reached 76.3 million USD, hence relevant findings of the study are expected to provide technical guidance on the treatment of high-temperature-induced damage in deep mines.