Monitorización de los valores séricos de vitamina D en mujeres con osteoporosis posmenopáusica tratadas con dosis habituales de vitamina D

Ivorra, José Andrés Román; Valls, E.; Comella, Nagore Fernández-Llanio; Verdejo, I. Chalmeta; Oliver, María Jesús Oliver

doi:10.1016/j.medcli.2011.07.024

Cited by 9 publications

(3 citation statements)

References 9 publications

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“…This outcome is comparable to a previous study in Spanish women where 27.7% of the patients achieved adequate 25(OH)D levels (≥30 ng/mL) after administration of 800–1,000 IU/day of vitamin D for 3 months. [14] However, the optimal 25(OH)D level was achieved in 72.5% of the patients after education, by taking a recommended dose (cholecalciferol 800–1,000 IU/day) without additional prescription of vitamin D supplement. This proportion is comparable to the achievement rate of optimal 25(OH)D levels by taking 800–1,000 IU/day of vitamin D in women diagnosed with osteoporosis for the first time.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Education and Vitamin D Supplementation on the Achievement of Optimal Vitamin D Level in Korean Postmenopausal Women

et al. 2019

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BackgroundDespite daily vitamin D recommendations, women with osteoporosis may not achieve optimal 25-hydroxy-vitamin D (25[OH]D) levels. We retrospectively evaluated the effect of education and vitamin D supplementation (1,000 IU/day) in Korean women with osteoporosis.MethodsSixty-one women with osteoporosis who were taking cholecalciferol (800–1,000 IU/day) were enrolled during 2011 to 2012. Forty patients (education only, Edu group) were educated on the importance of >30 min sunlight exposure daily while taking vitamin D. Twenty-one patients (education with vitamin D supplementation, Add group) were prescribed 1,000 IU/day cholecalciferol (total 1,800–2,000 IU/day) plus education. Patients were divided into 3 groups according to serum 25(OH)D status: deficiency (<20 ng/mL), insufficiency (20–30 ng/mL), and sufficiency (≥30 ng/mL). Furthermore, 25(OH)D levels were compared at baseline and after intervention for 3 months.ResultsThe median (interquartile range) serum 25(OH)D concentration at baseline was 25.10 (18.95–33.60) ng/mL. The mean (±standard error) differences in 25(OH)D levels from baseline to post-intervention were 19.85±3.86 and 31.73±4.82 ng/mL in the Edu group and Add group, respectively. Eighteen patients (29.5%) had vitamin D deficiency, 25 (41.0%) had insufficiency, and 18 (29.5%) had sufficient levels. Optimal 25(OH)D (30 ng/mL or more) was achieved in 54.5% and 95.2% patients in the Edu group and Add group, respectively (P=0.003).ConclusionsWe consider that vitamin D concentration should be measured on a regular basis in order to maintain an optimal level of vitamin D concentration, and education and supplementation is needed if not sufficient.

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Section: Discussionmentioning

confidence: 99%

The Effect of Education and Vitamin D Supplementation on the Achievement of Optimal Vitamin D Level in Korean Postmenopausal Women

et al. 2019

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“…In a previous study on Spanish women after vitamin D administration for 3 months, women maintaining serum 25-(OH)D levels of more than 30 ng/mL were 27.7% in the group with vitamin D intake of 800-1,000 IU/day, 53.6% in the group with 1,000-1,600 IU/day, and 90.2% in the group with 1,600 IU or over. [ 13 ] In another study on white American women, the Recommended Dietary Allowance (RDA) was obtained as daily reference values for reaching target serum 25-(OH)D levels in more than 97.5% of women. The RDA values were 800 IU/day at 20 ng/mL and 1,600 IU/day at 30 ng/mL as standard.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status and Response to Initial Vitamin D Supplementation in Korean Women with Osteoporosis

Kim

Yoon

et al. 2014

J Bone Metab

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BackgroundThe aim of this study is to evaluate whether the optimal vitamin D level is achieved after taking recommended dose in vitamin D deficient patients.MethodsThis was a retrospective study. Women (n=52) first diagnosed with osteoporosis were recruited in outpatient clinic. They were recommended to be exposed to sun light for more than 30 min a day. Subjects were divided into 3 groups according to serum 25-hydroxy-vitamin D3 (25-[OH]D3) status: deficiency (less than 20 ng/mL), insufficiency (20-30 ng/mL) and sufficiency (30 ng/mL or more). Insufficient and sufficient patients received the recommended dose (1,000 IU/day) but deficient patients received recommended or double dose (1,800-2,000 IU/day). We compared 25-(OH)D levels at baseline and after vitamin D supplementation for 3 months.ResultsMedian (interquartile range) serum 25-(OH)D concentration at baseline was 15.10 (13.30-16.97) ng/mL and the proportion of deficient, insufficient and sufficient groups were 69.2%, 23.1%, and 7.7% respectively. The optimal 25-(OH)D level (30 ng/mL or more) was achieved in 83.3% of insufficient patients with the recommended dose and was did in 55.6% of deficient patients with recommended dose (P=0.117). However, 88.9% of the deficient patient with double dose achieved optimal level (P=0.030).ConclusionsAbout 44% of vitamin D deficient patients did not attain the optimal level of serum 25-(OH)D despite recommended daily intake of vitamin D to 1,000 IU in patients with osteoporosis. Follow-up of serum 25-(OH)D levels may be required for vitamin D supplementation in vitamin D deficient patients with osteoporosis.

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“…Sin embargo, los datos extrapolados de metaanálisis siempre se refieren a medidas poblacionales sobre las que los diferentes individuos se pueden situar de forma má s o menos distante del pará metro centralizador de referencia. Ello hace especialmente valiosos trabajos como el de Ivorra et al 21 que aparece en este nú mero de Medicina Clı´nica. De hecho, un metaaná lisis má s reciente utilizando los datos de má s de 68.000 pacientes de 7 ensayos clínicos, lo que le dota de mayor potencia metodoló gica, no ha demostrado esta eficacia antifracturaria 20 .…”

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Suplementos de vitamina D. Las dosis recomendadas son insuficientes

Pérez¹

2012

Medicina Clínica

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Monitorización de los valores séricos de vitamina D en mujeres con osteoporosis posmenopáusica tratadas con dosis habituales de vitamina D

Cited by 9 publications

References 9 publications

The Effect of Education and Vitamin D Supplementation on the Achievement of Optimal Vitamin D Level in Korean Postmenopausal Women

The Effect of Education and Vitamin D Supplementation on the Achievement of Optimal Vitamin D Level in Korean Postmenopausal Women

Vitamin D Status and Response to Initial Vitamin D Supplementation in Korean Women with Osteoporosis

Suplementos de vitamina D. Las dosis recomendadas son insuficientes

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