“…No evidence of human-to-human transmission was identified, and most of the human cases presented with scattered skin lesions. The transmission route of the 2022 global outbreak, on the contrary, was mainly through intimate human-to-human contact, and many cases showed abundant skin lesions with mucosal involvement [6][7][8]. The latter outbreak has brought formidable challenges to the healthcare professionals and public health agencies in many nonendemic areas because of its unusual mode of transmission and atypical presentation on top of the general unfamiliarity of the disease [9].…”