Archaeoprimatology explores how humans and nonhuman primates coexisted in the past. This discipline has profound roots in texts of early scholars. Archaeoprimatological research examines the liminality between humans, apes, monkeys, and prosimians deep in time before the rise of the Anthropocene. By exploring the beginning of the relationship between modern Homo sapiens and primates, which possibly dates to approximately 100,000 BCE, I survey the evidence, ranging from portable objects and 2D surfaces with primatomorphic depictions to primate remains at archaeological sites worldwide. For example, an overview of ancient frescoes and mosaics with primate representations reveals that the vast majority of them were rendered in locations where primates were not part of the local fauna. An extensive review of primates in the zooarchaeological record shows as a global pattern that traded primates were usually young individuals and frugivorous/omnivorous species. Local primates yielded at sites of regions they naturally inhabited were mostly hunted. Thus, examining past patterns of the human–nonhuman primate interface provides insight into major questions about human niche construction and primate conservation today.