Mono- and ditopic hydroxamate ligands towards discrete and extended network architectures

Fugu, M. B.; Ellaby, Rebecca J.; O’Connor, Helen M.; Pitak, Mateusz B.; Klooster, Wim T.; Coles, Simon J.; Al‐Mashhadani, Mohammed H.; Perepichka, Igor F.; Brechin, Euan K.; Jones, Leigh F.

doi:10.1039/c9dt01531k

Cited by 9 publications

(3 citation statements)

References 38 publications

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“…In these scenarios, a controlled and gradual release of the drug becomes crucial. Some drugs may need to be taken in a specific body environment, while others necessitate consistent concentration within the digestive system [2,3]. The modification of pharmaceutical capsules by formulation changes or extra coatings gives a workable answer to the issue of improved drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Gelatin-Immobilized Cu(II) Metal Complex: Synthesis and Applications

Ahmed,

Ibraheem,

Al-Mashhadani

et al. 2024

Trends Sci

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Gelatin, resulting from collagen, a naturally occurring protein found in ligaments and tissues, is formed through the boiling of connective tissues, bones and animal skins, commonly sourced from cows. Its exceptional properties, including the ability to form strong, transparent gels and flexible films, easy digestibility, solubility in hot water and positive binding action, make gelatin a highly valuable resource in various industries such as food processing, pharmaceuticals, photography and paper production. It is regarded as non-toxic, biocompatible, biodegradable and generally safe for use. Gelatin serves as a key ingredient in the manufacturing of a wide range of products, with a notable example being hard gelatin capsules, which come in varying levels of solubility in water. In this study, a Schiff base was synthesized by modifying gelatin with salicylaldehyde in ethanol at room temperature, a mixture of gelatin-Schiff base added to appropriate copper chloride sonicated in ethanol, the mixture was poured onto glass plates and allowed to dry. Modified gelatin film was produced and characterized using FTIR spectroscopy, while its surface properties were examined through Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM). Furthermore, the modified gelatin film’s potential biological activity was assessed against bacterial strains. The antibacterial screening tests revealed that the modified gelatin exhibited promising antibacterial activity against microorganisms, indicating an improvement in its antibacterial efficacy. These findings highlight the enhanced antibacterial potential of the modified gelatin film, further contributing to its versatility and potential applications in various fields. Different molecular weight distributions within the gelatin can lead to variations in film formation and subsequent surface features. Additionally, the composition of the gelatin film, including the presence of any crosslinking agents or modified functional groups, can further influence the resulting surface morphology. This study focuses on the preparation of modified gelatin films using suitable aldehyde compounds and explores their potential for pharmaceutical applications. Various techniques assessment of biological activity will be employed to investigate the properties and performance of the modified gelatin films. HIGHLIGHTS A Schiff base was synthesized by modifying gelatin with salicylaldehyde, a mixture of gelatin-Schiff base added to appropriate copper chloride to produce gelatin-Schiff base-Cu(II) complex Modified gelatin characterized using FTIR spectroscopy, while its surface properties were examined through SEM and AFM The modified gelatin film’s potential biological activity was assessed against bacterial strains GRAPHICAL ABSTRACT

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Section: Introductionmentioning

confidence: 99%

Gelatin-Immobilized Cu(II) Metal Complex: Synthesis and Applications

Ahmed,

Ibraheem,

Al-Mashhadani

et al. 2024

Trends Sci

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“…For the development of new interesting materials based on coordination compounds, polytopic or polyfunctional ligands are interesting candidates [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Both types can help to selectively assemble discrete mononuclear or polynuclear complexes [ 1 , 2 , 3 , 4 , 7 , 8 , 9 ], clusters [ 6 , 7 ], or coordination polymers [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ] including metal-organic frameworks (MOFs) [ 8 , 10 ] either by providing more than one coordination site (polytopic) or other functionalities (polyfunctional) enabling secondary interactions such as hydrogen bonds, halogen bonds, π-stacking, or hydrophobic van der Waals interactions [ 11 , 12 , 13 , 14 , 15 , 16 ]. Additionally, the nature of the ligand combined with the h ard and s oft a cids-and b ases principle (HSAB) help in taming the quite flexible geometries of many 3D transition metals.…”

Section: Introductionmentioning

confidence: 99%

Structure, Optical and Magnetic Properties of Two Isomeric 2-Bromomethylpyridine Cu(II) Complexes [Cu(C6H9NBr)2(NO3)2] with Very Different Binding Motives

et al. 2023

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Two isomeric 2-bromomethylpyridine Cu(II) complexes [Cu(C6H9NBr)2(NO3)2] with 2-bromo-5-methylpyridine (L1) and 2-bromo-4-methylpyridine (L2) were synthesized as air-stable blue materials in good yields. The crystal structures were different with [Cu(L1)2(NO3)2] (CuL1) crystallizing in the monoclinic space group P21/c, while the 4-methyl derivative CuL2 was solved and refined in triclinic P1¯. The orientation of the Br substituents in the molecular structure (anti (CuL1) vs. syn (CuL2) conformations) and the geometry around Cu(II) in an overall 4 + 2 distorted coordination was very different with two secondary (axially elongated) Cu–O bonds on each side of the CuN2O2 basal plane in CuL1 or both on one side in CuL2. The two Br substituents in CuL2 come quite close to the Cu(II) centers and to each other (Br⋯Br ~3.7 Å). Regardless of these differences, the thermal behavior (TG/DTA) of both materials is very similar with decomposition starting at around 160 °C and CuO as the final product. In contrast to this, FT-IR and Raman frequencies are markedly different for the two isomers and the UV–vis absorption spectra in solution show marked differences in the π–π* absorptions at 263 (CuL2) or 270 (CuL1) nm and in the ligand-to-metal charge transfer bands at around 320 nm which are pronounced for CuL1 with the higher symmetry at the Cu(II) center, but very weak for CuL2. The T-dependent susceptibility measurements also show very similar results (µeff = 1.98 µB for CuL1 and 2.00 µB for CuL2 and very small Curie–Weiss constants of about −1. The EPR spectra of both complexes show axial symmetry, very similar averaged g values of 2.123 and 2.125, respectively, and no hyper-fine splitting.

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“…The introduction of a secondary amine group rendered the resultant ligand non-planar as illustrated upon subsequent Cu(II) ligation when forming the 12-MC-4 Cu(II) metallacrown [Cu(II) 5 (L 2 -H) 4 (MeOH) 2 ](NO 3 ) 2 •3H 2 O•4MeOH. 16…”

Section: Introductionmentioning

confidence: 99%

Slight ligand modifications within multitopic linear hydroxamates promotes connectivity differences in Cu(ii) 1-D coordination polymers

et al. 2021

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Mono- and ditopic hydroxamate ligands towards discrete and extended network architectures

Abstract: A family of mono- and ditopic hydroxamic acids has been employed in the synthesis of discrete (0D) and (1- and 2-D) extended network coordination complexes.

Cited by 9 publications

References 38 publications

Gelatin-Immobilized Cu(II) Metal Complex: Synthesis and Applications

Gelatin-Immobilized Cu(II) Metal Complex: Synthesis and Applications

Structure, Optical and Magnetic Properties of Two Isomeric 2-Bromomethylpyridine Cu(II) Complexes [Cu(C6H9NBr)2(NO3)2] with Very Different Binding Motives

Slight ligand modifications within multitopic linear hydroxamates promotes connectivity differences in Cu(ii) 1-D coordination polymers

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