Mono- and polysubstance dependent subjects differ on social factors, childhood trauma, personality, suicidal behaviour, and comorbid Axis I diagnoses

Martinotti, Giovanni; Carli, Vladimir; Tedeschi, D.; Giannantonio, Massimo Di; Roy, Alec; Janiri, Luigi; Sarchiapone, Marco

doi:10.1016/j.addbeh.2009.04.012

Cited by 120 publications

(93 citation statements)

References 36 publications

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“…Accordingly, PDMP data revealed that INTX‐associated treatment had its most profound effects in reducing opioid prescriptions, doses, opioid types, numbers prescribers, and dispensing pharmacies in patients with opioid use disorders uncomplicated by alcohol disorders. These findings are in general agreement with studies indicating that the presence of multiple addictions renders patients more treatment refractory,26, 27 suggesting the need for more research into improving INTX efficacy in patients with comorbid opioid and alcohol disorders.…”

Section: Discussionsupporting

confidence: 90%

Prescription drug monitoring program data tracking of opioid addiction treatment outcomes in integrated dual diagnosis care involving injectable naltrexone

et al. 2016

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Background and ObjectivesFourfold increases in opioid prescribing and dispensations over 2 decades in the U.S. has paralleled increases in opioid addictions and overdoses, requiring new preventative, diagnostic, and treatment strategies. This study examines Prescription Drug Monitoring Program (PDMP) tracking as a novel measure of opioid addiction treatment outcomes in a university‐affiliated integrated mental health‐addiction treatment clinic.MethodsRepeated measure parametrics examined PDMP and urine drug screening (UDS) data before and after first injection for all patients (N = 68) who received at least one long‐acting naltrexone injection (380 mg/IM) according to diagnostic groupings of having either (i) alcohol (control); (ii) opioid; or (iii) combined alcohol and opioid use disorders.ResultsThere were no group differences post‐injection in treatment days, injections delivered, or treatment service encounters. UDS and PDMP measures of opioid exposures were greater in opioid compared to alcohol‐only patients. Post‐first injection, UDS's positive for opioids declined (p < .05) along with PDMP measures of opioid prescriptions (p < .001), doses (p < .01), types (p < .001), numbers of dispensing prescribers (p < .001) and pharmacies (p < .001). Opioid patients without alcohol disorders showed the best outcomes with 50% to 80% reductions in PDMP‐measures of opioids, down to levels of alcohol‐only patients.ConclusionsThis study shows PDMP utility for measuring opioid addiction treatment outcomes, supporting the routine use of PDMPs in clinical and research settings.Scientific SignificanceThese findings demonstrate that opioid addiction in patients with complex addictions and mental illnesses comorbidities can show effective treatment responses as measured by PDMP tracking of decreases in opioid prescriptions to those patients. (Am J Addict 2016;25:557–564)

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Section: Discussionsupporting

confidence: 90%

Prescription drug monitoring program data tracking of opioid addiction treatment outcomes in integrated dual diagnosis care involving injectable naltrexone

et al. 2016

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“…Higher scores indicate greater childhood mistreatment. The CTQ has been used in both non-clinical (Scher et al, 2001) and clinical populations (Martinotti et al, 2009;Uçok and Bikmaz, 2007). It has a high degree of reliability (Bernstein et al, 1994) and it was also recently used to assess patients with affective disorders (Etain et al, 2010;Garno et al, 2005;Polanczyk et al, 2009).…”

Section: Clinical Assessmentmentioning

confidence: 99%

Childhood traumatic experiences of patients with bipolar disorder type I and type II

Janiri

Sani

Danese

et al. 2015

Journal of Affective Disorders

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“…childhood emotional neglect) and personality (e.g. impulsivity) characteristics [13], we expect to find several differences between these clinical groups, with PUD inpatients showing greater impairments than AUD inpatients. Compared to CS, we expect both SUD groups to be defined by more insecure attachment and a higher amount of borderline personality organization.…”

Section: Introductionmentioning

confidence: 99%

Insecure Attachment Styles and Increased Borderline Personality Organization in Substance Use Disorders

Hiebler‐Ragger

Unterrainer²,

Rinner³

et al. 2016

Psychopathology

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Background: Previous research has linked insecure attachment styles and borderline personality organization to substance use disorder (SUD). However, it still remains unclear whether those impairments apply to different kinds of SUDs to the same extent. Therefore, in this study we sought to investigate potential differences regarding attachment deficits and borderline personality organization in two different SUD inpatient groups and furthermore in comparison to healthy controls. Sampling and Methods: A total of 66 (24 female) inpatients diagnosed with alcohol use disorder (AUD), 57 (10 female) inpatients diagnosed with polydrug use disorder (PUD), and 114 (51 female) healthy controls completed the Borderline Personality Inventory and the Attachment Style Questionnaire. Results: Compared to healthy controls, AUD and PUD inpatients showed significant deficits in all attachment parameters (p < 0.01) as well as a significantly increased amount of borderline personality organization (p < 0.01). No differences between AUD and PUD inpatients were observed (p > 0.05). Conclusions: Our results indicate that the drug(s) of choice cannot be regarded as an indicator for the extent of attachment deficits or personality pathology. These initial findings are mainly limited by the rather small sample size as well as just a single point of measurement. Future research might also consider further covariates such as comorbidity or psychotropic medication.

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Mono- and polysubstance dependent subjects differ on social factors, childhood trauma, personality, suicidal behaviour, and comorbid Axis I diagnoses

Cited by 120 publications

References 36 publications

Prescription drug monitoring program data tracking of opioid addiction treatment outcomes in integrated dual diagnosis care involving injectable naltrexone

Prescription drug monitoring program data tracking of opioid addiction treatment outcomes in integrated dual diagnosis care involving injectable naltrexone

Childhood traumatic experiences of patients with bipolar disorder type I and type II

Insecure Attachment Styles and Increased Borderline Personality Organization in Substance Use Disorders

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