Mono- Or Combined Antihypertensive Therapy in Women With Arterial Hypertension and Moderate Risk of Cardiovascular Diseases: What’s Better?

Stryuk, R. I.; Brytkova, Ya. V.; Tatarinova, O. V.

doi:10.21518/2079-701x-2017-20-40-44

Med. sov.

2017

DOI: 10.21518/2079-701x-2017-20-40-44

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Mono- Or Combined Antihypertensive Therapy in Women With Arterial Hypertension and Moderate Risk of Cardiovascular Diseases: What’s Better?

R. I. Stryuk¹,

Ya. V. Brytkova²,

O. V. Tatarinova³

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2023

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Cited by 2 publications

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Special features of microcirculatory disorders in patients with comorbid hypertension and rheumatoid arthritis

Samorodskaya,

Eliseeva

2023

Arter. gipertenz.

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Background. During the recent years, there has been a steadily growing interest in the problems of microcirculatory disorders (MD) in patients with cardiological and rheumatological profile that is determined by a significant role of microcirculatory in the pathogenesis of these diseases.Objective. Analysis of the MD special features in patients with hypertension (HTN) and rheumatoid arthritis (RA).Design and methods. Patients matching the inclusion criteria by age (58,6 ± 6,4 years), debut (aged 45–64 years) and RA experience (7,2 ± 2,1 years) and HTN duration (11,2 ± 1,6 years) were divided into three groups: I group — 277 patients with stage II HTN; II group — 142 patients with stage II HTN and RA (in clinical and laboratory remission); group III — 112 patients with stage II HTN and RA (in clinical and laboratory exacerbation). The study of the microcirculatory bed was performed on an outpatient basis by laser Doppler flowmetry according to a standard technique. Results. Microcirculatory bed analysis in patients with HTN and RA showed the variability of indicators depending on gender characteristics, body weight and microcirculatory type. The study of the amplitude-frequency spectrum in women with stasis, in men with spastic and normocirculatory types of microcirculation showed an increase in neurogenic tone, endothelial activity and some decrease in the amplitude of oscillatory processes at the periphery.Conclusions. In patients with HTN and RA, changes at the microcirculatory level were determined, they manifested by an increase in adrenergic tone, spastic phenomena, endothelial activation, some decrease in blood flow variability and more pronounced vasomotor dysfunction that is not only the result of RA presence but its activity. RA in this situation could be regarded as a surrogate marker for the unfavorable course of HTN.

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Special features of microcirculatory disorders in patients with comorbid hypertension and rheumatoid arthritis

Samorodskaya,

Eliseeva

2023

Arter. gipertenz.

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Hemodynamic eﬀects of antihypertensive therapy in patients with hypertension and rheumatoid arthritis comorbidity

Samorodskaya

Елисеева

2023

jour

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Research objective. Evaluation of the influence of 6-month antihypertensive therapy with drugs of diﬀerent classes on hemodynamic parameters of the circulatory system in patients with comorbid hypertension and rheumatoid arthritis. Materials and methods. Patients who met age criteria (58.6 ± 6.4 years), duration of hypertension (11.2 ± 1.6 years), onset (aged 45–64 years), and duration (7.2 ± 2.1 years) of rheumatoid arthritis were divided into groups: Group I (136 men, 141 women) — 277 patients with stage II hypertension; Group II (28 men, 114 women) — 142 patients with stage II hypertension and rheumatoid arthritis (in clinical-laboratory remission); Group III (20 men, 92 women) — 112 patients with stage II hypertension and rheumatoid arthritis (in clinical-laboratory exacerbation). Antihypertensive monotherapy was prescribed by polyclinic doctors: nebivolol, lisinopril, losartan, amlodipine, indapamide, and a combination of lisinopril and indapamide. Observation was carried out for 6 months. Results. The influence of antihypertensive therapy (6 months) on hemodynamic parameters of the circulatory system in patients of groups I and II was presented by positive dynamics of morphometric and speed parameters, while in group III patients the indicators were less significant and more distant. Conclusion. The presence of rheumatoid arthritis introduces additional changes in the dynamics of hemodynamic eﬀects of prescribed antihypertensive therapy and is determined by the degree of disease activity and adequacy of basic anti-inflammatory therapy.

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Mono- Or Combined Antihypertensive Therapy in Women With Arterial Hypertension and Moderate Risk of Cardiovascular Diseases: What’s Better?

Cited by 2 publications

References 12 publications

Special features of microcirculatory disorders in patients with comorbid hypertension and rheumatoid arthritis

Special features of microcirculatory disorders in patients with comorbid hypertension and rheumatoid arthritis

Hemodynamic eﬀects of antihypertensive therapy in patients with hypertension and rheumatoid arthritis comorbidity

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