2013
DOI: 10.1016/j.jcjd.2013.03.019
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Monoacylglycerol as a Metabolic Coupling Factor in Glucose-Stimulated Insulin Secretion

Abstract: In the present study we demonstrate that the obliterated GSIS due to lipolysis inhibition incells can be restored by providing exogenous MAG. In the -cells MAG levels increase significantly in the presence of high glucose concentration and specific inhibition of the major MAG hydrolase, abhydrolase-6 (ABHD6), in -cells and islets with WWL70 leads to accumulation of MAG with concomitant increase in insulin secretion. Lipidomics analysis v indicated that the major MAG species that is elevated by high glucose as … Show more

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Cited by 1 publication
(2 citation statements)
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References 204 publications
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“…The full hydrolysis is accomplished by the combined action of adipose triacylglycerol lipase (ATGL), hormone sensitive lipase (HSL), and monoacylglycerol lipase (MAGL), and to our knowledge there are no reports of triacylglycerol derived monoacylglycerol signaling in adipose tissue. However, in the intestine and pancreas, there is emerging evidence that nonendocannabinoid 2‐MAGs may be involved in metabolic homeostasis .…”
Section: 2‐monoacylglycerolsmentioning
confidence: 99%
See 1 more Smart Citation
“…The full hydrolysis is accomplished by the combined action of adipose triacylglycerol lipase (ATGL), hormone sensitive lipase (HSL), and monoacylglycerol lipase (MAGL), and to our knowledge there are no reports of triacylglycerol derived monoacylglycerol signaling in adipose tissue. However, in the intestine and pancreas, there is emerging evidence that nonendocannabinoid 2‐MAGs may be involved in metabolic homeostasis .…”
Section: 2‐monoacylglycerolsmentioning
confidence: 99%
“…In cell types with sparse triacylglycerol storage like those of the brain, 2‐MAGs are intermediates of phospholipid turnover, and consequently they have the potential to exert signaling functions of their own or interfere with the signaling of structurally related compounds like the endocannabinoid, 2‐AG. The signaling properties of 2‐AG in nervous tissue is widely studied, but only recently focus has been aimed at the signaling properties of other 2‐monacylglycerols and their potential roles in various tissues . In brain tissue the main pool of 2‐AG probably originates from hydrolysis of membrane associated phosphoinositides by action of phospholipase C (PLC) and membrane associated diacylglycerol lipases (DAGLα and β) .…”
Section: 2‐monoacylglycerolsmentioning
confidence: 99%