Monoamine Involvement in the Antidepressant-Like Effect of β-Caryophyllene

Oliveira, Danillo Ramos de; Silva, Dayane Moreira da; Florentino, Iziara Ferreira; Brito, Adriane Ferreira de; Fajemiroye, James Oluwagbamigbe; Silva, Daiany Priscilla Bueno da; Rocha, Fábio Fagundes da; Costa, Élson Alves; Galdino, Pablinny Moreira

doi:10.2174/1871527317666180420150249

Cited by 23 publications

(12 citation statements)

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“…Neurological scores were improved in mice administered β-caryophyllene (24 and 72 mg/ kg, i.p.) following an induced stroke [62] and anti-depressant-like behaviour was reported in healthy mice following β-caryophyllene, through mechanisms involving catecholamine (adrenergic) neurotransmission [63]. Overall, the studies provide some evidence to support the role of β-caryophyllene as pro-cognitive, with anti-inflammatory, neuroprotective and anti-depressant effects.…”

Section: Beta-caryophyllenementioning

confidence: 63%

The United Chemicals of Cannabis: Beneficial Effects of Cannabis Phytochemicals on the Brain and Cognition

Weston–Green¹

2019

Recent Advances in Cannabinoid Research

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'Medicinal cannabis' can be defined as pharmaceutical grade cannabis-based products used for the treatment of illness. Beneficial treatment effects of cannabidiol (CBD), a major non-intoxicating compound isolated from the cannabis plant, have been shown in multiple states of cognitive impairment, including neurodegenerative (Alzheimer's, Huntington's and Parkinson's disease), neuroinflammatory (sepsis-induced encephalopathy) and neurological disorders (ischemic brain injury). CBD can also treat some of the symptoms of schizophrenia, including cognitive deficits (impairments in learning and memory), which is a major symptom domain of the illness that is largely resistant to existing antipsychotic medications. However, empirical evidence suggests the presence of an 'entourage effect' in cannabis; that is, observations that medicinal cannabis seems to work better in some instances when administered as a whole-plant extract. While scientific evidence highlights isolated CBD as a strong candidate for treating cognitive impairment, the entourage effect suggests that the cooperation of other plant molecules could provide further benefits. This chapter explores the scientific evidence surrounding the benefits of CBD and other specific key phytochemicals in cannabis: linalool, α-pinene, β-caryophyllene, flavonoids and anthocyanin, on brain health and cognition.

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Section: Beta-caryophyllenementioning

confidence: 63%

The United Chemicals of Cannabis: Beneficial Effects of Cannabis Phytochemicals on the Brain and Cognition

Weston–Green¹

2019

Recent Advances in Cannabinoid Research

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“…The main chemical compound present in the supercritical CO 2 extract of C. xanthocarpa seeds is β-caryophyllene (11.67%), 15 which antidepressant-like effects were already demonstrated. 48 , 49 , 50 Bahi et al., showed the involvement of cannabinoid CB2 receptors in the mode of β-caryophyllene pharmacological action. 50 In fact, the cannabinoid-dependent activation of monoaminergic signaling has already been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant-like effect of Campomanesia xanthocarpa seeds in mice: Involvement of the monoaminergic system

Anzollin

Zaki

Perin

et al. 2022

Journal of Traditional and Complementary Medicine

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“…Although the pharmacological significance of these activities is ambiguous, they may interfere with experimental results. Therefore, special attention was paid to dose selections and these agents were administrated in previously used doses [ 14 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ], at which disappearance of the pharmacological effect have been associated to the involvement of targeted receptors in the activity. On the other hand, it is clear that further mechanical studies with various doses of antagonists would be useful to confirm the receptors that mediate the central analgesic effect of vortioxetine.…”

Section: Discussionmentioning

confidence: 99%

5-HT1A Serotonergic, α-Adrenergic and Opioidergic Receptors Mediate the Analgesic Efficacy of Vortioxetine in Mice

et al. 2021

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Vortioxetine is a multimodal antidepressant drug that affects several brain neurochemicals and has the potential to induce various pharmacological effects on the central nervous system. Therefore, we investigated the centrally mediated analgesic efficacy of this drug and the mechanisms underlying this effect. Analgesic activity of vortioxetine (5, 10 and 20 mg/kg, p.o.) was examined by tail-clip, tail-immersion and hot-plate tests. Motor performance of animals was evaluated using Rota-rod device. Time course measurements (30–180 min) showed that vortioxetine (10 and 20 mg/kg) administrations significantly increased the response latency, percent maximum possible effect and area under the curve values in all of the nociceptive tests. These data pointed out the analgesic effect of vortioxetine on central pathways carrying acute thermal and mechanical nociceptive stimuli. Vortioxetine did not alter the motor coordination of mice indicating that the analgesic activity of this drug was specific. In mechanistic studies, pre-treatments with p-chlorophenylalanine (serotonin-synthesis inhibitor), NAN-190 (serotonin 5-HT1A receptor antagonist), α-methyl-para-tyrosine (catecholamine-synthesis inhibitor), phentolamine (non-selective α-adrenoceptor blocker), and naloxone (non-selective opioid receptor blocker) antagonised the vortioxetine-induced analgesia. Obtained findings indicated that vortioxetine-induced analgesia is mediated by 5-HT1A serotonergic, α-adrenergic and opioidergic receptors, and contributions of central serotonergic and catecholaminergic neurotransmissions are critical for this effect.

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Monoamine Involvement in the Antidepressant-Like Effect of β-Caryophyllene

Abstract: This study provides a new mechanism of BCP-induced antidepressant-like effect mediated by some sub-types of catecholaminergic neurotransmitter system that could be a candidate for clinical tests of new treatments for depressive disorders.

Cited by 23 publications

References 0 publications

The United Chemicals of Cannabis: Beneficial Effects of Cannabis Phytochemicals on the Brain and Cognition

The United Chemicals of Cannabis: Beneficial Effects of Cannabis Phytochemicals on the Brain and Cognition

Antidepressant-like effect of Campomanesia xanthocarpa seeds in mice: Involvement of the monoaminergic system

5-HT1A Serotonergic, α-Adrenergic and Opioidergic Receptors Mediate the Analgesic Efficacy of Vortioxetine in Mice

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