Monoamine oxidase A and B activities in heavy smokers

Berlin, Ivan; Saïd, Sophie; Spreux‐Varoquaux, Odile; Olivares, Robert; Launay, Jean‐Marie; Puech, Alain J.

doi:10.1016/0006-3223(95)00084-4

Cited by 127 publications

(76 citation statements)

References 36 publications

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“…Other components of cigarettes, found much more equally in the two cigarettes, and not the nicotine content of the cigarettes themselves, might potentially affect these responses. For example, several groups (Berlin et al 1995;Fowler et al 1996;Simpson et al 1999) have reported decreases in platelet or brain MAO activity produced by cigarettes, which could theoretically increase brain dopamine activity. Nicotine itself does not inhibit MAO activity.…”

Section: Negative Symptomsmentioning

confidence: 99%

Effects of Cigarette Smoking and Nicotine Nasal Spray on Psychiatric Symptoms and Cognition In Schizophrenia

Smith

Singh

Infante

et al. 2002

Neuropsychopharmacology

220

170

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Section: Negative Symptomsmentioning

confidence: 99%

Effects of Cigarette Smoking and Nicotine Nasal Spray on Psychiatric Symptoms and Cognition In Schizophrenia

Smith

Singh

Infante

et al. 2002

Neuropsychopharmacology

220

170

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“…Different studies have indicated that tobacco smokers have decreased brain levels of monoamine oxidases (Berlin et al, 1995;Fowler et al, 1996). Actually, tobacco and tobacco smoke contain monoamine oxidases inhibitors (MAOIs) (Poindexter and Carpenter, 1962;Breyer-Pfaff et al, 1996;Rommelspacher et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Monoamine Oxidases Desensitizes 5-HT_1AAutoreceptors and Allows Nicotine to Induce a Neurochemical and Behavioral Sensitization

Lanteri

Vallejo²,

Salomon³

et al. 2009

J. Neurosci.

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Although nicotine is generally considered to be the main compound responsible for addictive properties of tobacco, experimental data indicate that nicotine does not exhibit all the characteristics of other substances of abuse. We recently showed that a pretreatment with mixed irreversible monoamine oxidases inhibitors (MAOIs), such as tranylcypromine, triggers a locomotor response to nicotine in mice and allows maintenance of behavioral sensitization to nicotine in rats. Moreover, we showed by microdialysis in mice that behavioral sensitization induced by compounds belonging to main groups of drugs of abuse, such as amphetamine, cocaine, morphine, or alcohol, was underlain by sensitization of noradrenergic and serotonergic neurons. Here, this neurochemical sensitization was tested after nicotine, tranylcypromine, or a mixture of both compounds. Data indicate that, whereas neither repeated nicotine nor repeated tranylcypromine alone has any effect by itself, a repeated treatment with a mixture of nicotine and tranylcypromine induces both behavioral sensitization and sensitization of noradrenergic and serotonergic neurons.

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“…Many authors have found that tobacco smokers, when compared to nonsmokers, have MAO-A and -B activities that are reduced by up to 40% (Oreland et al, 1981;Yu and Boulton, 1987;Berlin et al, 1995;Fowler et al, 1996a, b). Inhibition of monoamine oxidases (MAOs) by tobacco smoke does not result from the actions of nicotine (Carr and Basham, 1991), but from that of other compounds that are also present in other psychotropic plants (Uebelhack et al, 1998;Rommelspacher et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Monoamine Oxidase Inhibitors Allow Locomotor and Rewarding Responses to Nicotine

Villegier

Salomon

Granon

et al. 2005

Neuropsychopharmacol

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Although nicotine is generally considered to be the main compound responsible for the addictive properties of tobacco, experimental data indicate that nicotine does not exhibit all the characteristics of other abused substances, such as psychostimulants and opiates. For example, nicotine is only a weak locomotor enhancer in rats and generally fails to induce a locomotor response in mice. This observation contradicts the general consensus that all drugs of abuse release dopamine in the nucleus accumbens, a subcortical structure, and thus increase locomotor activity in rodents. Because tobacco smoke contains monoamine oxidase inhibitors (MAOIs) and decreases MAO activity in smokers, we have combined MAOIs with nicotine to determine whether it is possible to obtain a locomotor response to nicotine in C57Bl6 mice. Among 15 individual or combined MAOIs, including harmane, norharmane, moclobemide, selegiline, pargyline, clorgyline, tranylcypromine and phenelzine, only irreversible inhibitors of both MAO-A and -B (tranylcypromine, phenelzine, and clorgyline + selegiline) allowed a locomotor response to nicotine. The locomotor stimulant interaction of tranylcypromine and nicotine was absent in b2-nicotinic acetylcholine receptor subunit knockout mice. Finally, it was found that, whereas naïve rats did not readily selfadminister nicotine (10 mg/kg/injection), a robust self-administration of nicotine occurred when animals were pretreated with tranylcypromine (3 mg/kg). Our data suggest that MAOIs contained in tobacco and tobacco smoke act in synergy with nicotine to enhance its rewarding effects.

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Monoamine oxidase A and B activities in heavy smokers

Cited by 127 publications

References 36 publications

Effects of Cigarette Smoking and Nicotine Nasal Spray on Psychiatric Symptoms and Cognition In Schizophrenia

Effects of Cigarette Smoking and Nicotine Nasal Spray on Psychiatric Symptoms and Cognition In Schizophrenia

Inhibition of Monoamine Oxidases Desensitizes 5-HT_1AAutoreceptors and Allows Nicotine to Induce a Neurochemical and Behavioral Sensitization

Monoamine Oxidase Inhibitors Allow Locomotor and Rewarding Responses to Nicotine

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Monoamine oxidase A and B activities in heavy smokers

Cited by 127 publications

References 36 publications

Effects of Cigarette Smoking and Nicotine Nasal Spray on Psychiatric Symptoms and Cognition In Schizophrenia

Effects of Cigarette Smoking and Nicotine Nasal Spray on Psychiatric Symptoms and Cognition In Schizophrenia

Inhibition of Monoamine Oxidases Desensitizes 5-HT1AAutoreceptors and Allows Nicotine to Induce a Neurochemical and Behavioral Sensitization

Monoamine Oxidase Inhibitors Allow Locomotor and Rewarding Responses to Nicotine

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Inhibition of Monoamine Oxidases Desensitizes 5-HT_1AAutoreceptors and Allows Nicotine to Induce a Neurochemical and Behavioral Sensitization