Monoamine Oxidase as a Potential Biomarker of the Efficacy of Treatment of Mental Disorders

Узбеков, М. Г.

doi:10.1134/s0006297921060146

Cited by 15 publications

(17 citation statements)

References 58 publications

(93 reference statements)

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“…The disturbance of monoamines, such as serotonin and norepinephrine levels, in the brain disrupts the hypothalamus-pituitary-adrenal axis which controls the response to stress, which ultimately leads to depression [ 43 , 44 , 45 ]. Monoamine oxidase (MAO) is one of the main enzymes in monoamine metabolism and is a potential biomarker of mental disorders [ 46 , 47 ]. Altered MAO activity in the brain disrupts levels of monoamine neurotransmitters such as dopamine, noradrenaline, and serotonin.…”

Section: Neurobiological Basis Of Depressionmentioning

confidence: 99%

“…Altered MAO activity in the brain disrupts levels of monoamine neurotransmitters such as dopamine, noradrenaline, and serotonin. Defective MAO also impacts mitochondria: it can affect the structure of mitochondrial membranes by activating oxidative stress and increasing the toxic levels of aldehydes and ammonia [ 46 , 47 ]. However, treatment with monoamines seems to have little beneficial effect on the mood of patients.…”

Section: Neurobiological Basis Of Depressionmentioning

confidence: 99%

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Connecting Dots between Mitochondrial Dysfunction and Depression

2023

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Mitochondria are the prime source of cellular energy, and are also responsible for important processes such as oxidative stress, apoptosis and Ca2+ homeostasis. Depression is a psychiatric disease characterized by alteration in the metabolism, neurotransmission and neuroplasticity. In this manuscript, we summarize the recent evidence linking mitochondrial dysfunction to the pathophysiology of depression. Impaired expression of mitochondria-related genes, damage to mitochondrial membrane proteins and lipids, disruption of the electron transport chain, higher oxidative stress, neuroinflammation and apoptosis are all observed in preclinical models of depression and most of these parameters can be altered in the brain of patients with depression. A deeper knowledge of the depression pathophysiology and the identification of phenotypes and biomarkers with respect to mitochondrial dysfunction are needed to help early diagnosis and the development of new treatment strategies for this devastating disorder.

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Section: Neurobiological Basis Of Depressionmentioning

confidence: 99%

Section: Neurobiological Basis Of Depressionmentioning

confidence: 99%

Connecting Dots between Mitochondrial Dysfunction and Depression

2023

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“…Hibiscus was also demonstrated to attenuate the effect of markers on the interface between oxidative stress and inflammation. COX-2 is a mediator in inflammatory action, while monoamine oxidase (MAO) plays a major role in the outer mitochondrial membrane, regulating the metabolism of monoaminergic neurotransmitters [ 129 , 134 ]. Compelling evidence involves both biomarkers in the progression of ROS-related inflammation in major metabolic disorders [ 149 , 150 ].…”

Section: The Potential Of Hibiscus Rooibos and Yerba Mate In Glycoxid...mentioning

confidence: 99%

Hibiscus, Rooibos, and Yerba Mate for Healthy Aging: A Review on the Attenuation of In Vitro and In Vivo Markers Related to Oxidative Stress, Glycoxidation, and Neurodegeneration

Lima

Boulanger

Tessier

et al. 2022

Foods

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The world is currently undergoing a demographic change towards an increasing number of elderly citizens. Aging is characterized by a temporal decline in physiological capacity, and oxidative stress is a hallmark of aging and age-related disorders. Such an oxidative state is linked to a decrease in the effective mechanisms of cellular repair, the incidence of post-translational protein glycation, mitochondrial dysfunction, and neurodegeneration, just to name some of the markers contributing to the establishment of age-related reduction-oxidation, or redox, imbalance. Currently, there are no prescribed therapies to control oxidative stress; however, there are strategies to elevate antioxidant defenses and overcome related health challenges based on the adoption of nutritional therapies. It is well known that herbal teas such, as hibiscus, rooibos, and yerba mate, are important sources of antioxidants, able to prevent some oxidation-related stresses. These plants produce several bioactive metabolites, have a pleasant taste, and a long-lasting history as safe foods. This paper reviews the literature on hibiscus, rooibos, and yerba mate teas in the context of nutritional strategies for the attenuation of oxidative stress-related glycoxidation and neurodegeneration, and, here, Alzheimer’s Disease is approached as an example. The focus is given to mechanisms of glycation inhibition, as well as neuroprotective in vitro effects, and, in animal studies, to frame interest in these plants as nutraceutical agents related to current health concerns.

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“…MAOA is a mitochondrial enzyme with primary function in the brain due to its involvement in the catabolism of monoamine neurotransmitters [ 41 , 42 ]. As such it has been implicated in mental illness and stress [ 43 , 44 ], but it also has a role in cancer progression. For example, in a mouse model of prostate cancer MAOA knockout mice had reduced risk of invasive cancer and a reduced population of CSCs [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Development of a long term, ex vivo, patient-derived explant model of endometrial cancer

van der Woude,

Phan,

Kenwright

et al. 2024

PLoS ONE

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Incidence of endometrial cancer (EC) is rising in the developed world. The current standard of care, hysterectomy, is often infeasible for younger patients and those with high body mass index. There are limited non-surgical treatment options and a lack of biologically relevant research models to investigate novel alternatives to surgery for EC. The aim of the present study was to develop a long-term, patient-derived explant (PDE) model of early-stage EC and demonstrate its use for investigating predictive biomarkers for a current non-surgical treatment option, the levonorgestrel intra-uterine system (LNG-IUS). Fresh tumour specimens were obtained from patients with early-stage endometrioid EC. Tumours were cut into explants, cultured on media-soaked gelatin sponges for up to 21 days and treated with LNG. Formalin-fixed, paraffin embedded (FFPE) blocks were generated for each explant after 21 days in culture. Tumour architecture and integrity were assessed by haematoxylin and eosin (H&E) and immunohistochemistry (IHC). IHC was additionally performed for the expression of five candidate biomarkers of LNG resistance. The developed ex vivo PDE model is capable of culturing explants from early-stage EC tumours long-term (21 Days). This model can complement existing models and may serve as a tool to validate results obtained in higher-throughput in vitro studies. Our study provides the foundation to validate the extent to which EC PDEs reflect patient response in future research.

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Monoamine Oxidase as a Potential Biomarker of the Efficacy of Treatment of Mental Disorders

Cited by 15 publications

References 58 publications

Connecting Dots between Mitochondrial Dysfunction and Depression

Connecting Dots between Mitochondrial Dysfunction and Depression

Hibiscus, Rooibos, and Yerba Mate for Healthy Aging: A Review on the Attenuation of In Vitro and In Vivo Markers Related to Oxidative Stress, Glycoxidation, and Neurodegeneration

Development of a long term, ex vivo, patient-derived explant model of endometrial cancer

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