Monoamine oxidase B in brains from patients with Alzheimer's disease: A biochemical and autoradiographical study

Jossan, S. S.; Gillberg, Per‐Göran; Gottfries, C. G.; Karlsson, Ingvar; Oreland, Lars

doi:10.1016/0306-4522(91)90098-9

Cited by 92 publications

(50 citation statements)

References 43 publications

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“…On the other hand, the introduction of a second phenyl ring connected via an ether (9) or a carbonyl moiety (12) Additionally, a second chlorine present in the C-5 position (21) further increased the inhibitory effect, which is in agreement with recently reported findings. 41 Functional groups other than chlorine (20 and 23) were not beneficial.…”

Section: Structure-activity Relationshipsupporting

confidence: 91%

“…[8][9][10] Alterations of both MAO-A and MAO-B activities (elevated enzyme levels or changes in expression in various brain regions) were reported in AD patient brains. [11][12][13] While elevated levels of MAO-B are well-described, changes in MAO-A activity are rather more complex and unclear. 14 In the periphery, inhibition of MAO-A can contribute to potential side effects, in particular to tyramine-induced hypertension (also referred as the "cheese effect").…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer’s disease treatment

Hroch

Guest

Benek

et al. 2017

Bioorganic & Medicinal Chemistry

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Section: Structure-activity Relationshipsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer’s disease treatment

Hroch

Guest

Benek

et al. 2017

Bioorganic & Medicinal Chemistry

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“…Furthermore, MAO B, but not MAO A, activity increases progressively in the brain throughout adult life (11,12). Aberrant increase of MAO B activity in the elderly has been implicated in neurodegenerative diseases such as Parkinson's disease (13), Alzheimer's disease (14), and Huntington's disease (15).…”

mentioning

confidence: 99%

Activation of Human Monoamine Oxidase B Gene Expression by a Protein Kinase C MAPK Signal Transduction Pathway Involves c-Jun and Egr-1

Wong¹,

Ou²,

Chen³

et al. 2002

Journal of Biological Chemistry

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Monoamine oxidases (MAO)A Monoamine oxidase (MAO)1 plays an important role in the metabolism of biogenic and dietary amines including the neurotransmitters serotonin, norepinephrine and dopamine, and tyramine and benzylamine. The degradation of monoamines by MAO yields hydrogen peroxide (H 2 O 2 ). Located in the outer mitochondrial membrane, the MAO exists in two isoforms (MAO A and MAO B) that exhibit distinct substrate and inhibitor specificity (for a review, see Ref. 1). MAO A deficiency was associated with a syndrome of impulsive aggressive behavior and mild mental retardation in affected males of a Dutch family (2). On the other hand, low platelet MAO B activity was implicated in bipolar disorders, suicidal behavior, alcoholism (3), sensation seeking (4), and poor impulse control (5).Although both MAO A and MAO B are widely distributed in the central nervous system and in the periphery, they differ in cell-and tissue-specific and developmental expressions. For instance, fibroblasts and placenta express predominantly MAO A (6, 7), whereas platelets and lymphocytes express predominantly MAO B (8). MAO A are found in catecholaminergic neurons, whereas MAO B are in serotonergic neurons and astrocytes (9, 10). Furthermore, MAO B, but not MAO A, activity increases progressively in the brain throughout adult life (11,12). Aberrant increase of MAO B activity in the elderly has been implicated in neurodegenerative diseases such as Parkinson's disease (13), Alzheimer's disease (14), and Huntington's disease (15).The human MAO A and MAO B are encoded by two different genes located on the X chromosome (Xp11.2-11.4) (16). The two genes consist of 15 exons with identical exon-intron organization (17) and share 70% sequence similarity in amino acid sequence (18). The 5Ј-flanking sequences of MAO A and MAO B genes have been sequenced and characterized. The maximal promoter activities for MAO A and MAO B genes were found to be in the Ϫ206/Ϫ60 and Ϫ246/Ϫ99 regions, respectively. Although both of these promoter regions are GC-rich and share ϳ60% sequence identity, they contain a distinct organization of cis-acting elements, which may explain differential expression of the MAO A and MAO B genes (19). In this study, we report the role of phorbol 12-myristate 13-acetate (PMA) in the regulation of MAO A and B genes. We showed that MAO B, but not MAO A, gene expression was rapidly induced following PMA treatment. The region between nucleotides Ϫ246 and Ϫ225 of MAO B promoter was essential for PMA-induced expression. The PMA-responsive region was further refined to a single Sp1/Egr-1/Sp1 overlapping binding site located between nucleotides Ϫ239 and Ϫ227. Our results also show that MAO B promoter activity is regulated via a mitogen activated protein kinase (MAPK) pathway that includes protein kinase C (PKC), Ras, MEK1, MEK3, MEK7, ERK2, JNK1, and p38/RK. EXPERIMENTAL PROCEDURESMaterials-The HepG2 (human hepatocytoma) cell line was purchased from the American Type Culture Collection and grown in Dulbecco's modified Eagle's medium su...

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“…MAO-B activity has been described to increase with age [20] and in brains of patients with neurodegenerative disorders such as AD [21], HD [22] and ALS [23] as well as after brain injury [37]. MAO-B is localized mainly in glial cells.…”

Section: Monoamine Oxidasementioning

confidence: 99%

Imaging of neuroinflammation

Ciarmiello

2011

Eur J Nucl Med Mol Imaging

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Monoamine oxidase B in brains from patients with Alzheimer's disease: A biochemical and autoradiographical study

Cited by 92 publications

References 43 publications

Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer’s disease treatment

Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer’s disease treatment

Activation of Human Monoamine Oxidase B Gene Expression by a Protein Kinase C MAPK Signal Transduction Pathway Involves c-Jun and Egr-1

Imaging of neuroinflammation

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