1980
DOI: 10.1016/0306-4522(80)90157-8
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Monoaminergic synapses in infant mouse neocortex: Comparison of cortical fields in seizure-prone and resistant mice

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Cited by 4 publications
(2 citation statements)
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“…Such rats have anomalous tyrosine hydroxylase activity (105) and NE concentration levels (247), whereas DA concentrations are normal (247). Furthermore, in the temporal cortex of epilepsy-prone mice, presumed monoaminergic synapses constitute only 4% of all synapses, compared with 20% in normal mice (277). These abnormal mice develop seizures in response to loud auditory stimuli, and it has been proposed that the loss of inhibitory monoaminergic synapses could facilitate the propagation of an audiogenic seizure through the cerebral cortex (277).…”
Section: Handbook Of Physiology -T H E Nervous System IVmentioning
confidence: 99%
“…Such rats have anomalous tyrosine hydroxylase activity (105) and NE concentration levels (247), whereas DA concentrations are normal (247). Furthermore, in the temporal cortex of epilepsy-prone mice, presumed monoaminergic synapses constitute only 4% of all synapses, compared with 20% in normal mice (277). These abnormal mice develop seizures in response to loud auditory stimuli, and it has been proposed that the loss of inhibitory monoaminergic synapses could facilitate the propagation of an audiogenic seizure through the cerebral cortex (277).…”
Section: Handbook Of Physiology -T H E Nervous System IVmentioning
confidence: 99%
“…The DBA/2 brain has been found to have much lower levels of serotonin (5-HT) and norepinephrine (NE), fewer binding sites for 3H-prazosin (a ligand of c~l-adrenergic receptors) [2], and a lower affinity of these receptors [5] than the C57B1 brain. Moreover, the temporal cortex of DBA/2 mice is reported to have far fewer monoamine-containing synapses than that of mice not susceptible to audiogenic seizures [8].Our previous studies demonstrated the importance of a balance between the activities of the brain serotoninergie and noradrenergic systems for the regulation of behavior; in particular, the two systems were shown to interact in a reciprocal …”
mentioning
confidence: 97%