Monoaminergic system and depression

Pérez-Caballero, Laura; Torres-Sánchez, Sonia; Romero-López-Alberca, Cristina; González‐Sáiz, Francisco; Micó, J.A.; Berrocoso, Esther

doi:10.1007/s00441-018-2978-8

Cited by 140 publications

(82 citation statements)

References 42 publications

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“…Despite the high global prevalence and social impact caused by depressive disorder, its pathophysiology is not yet fully understood, hence the importance of animals models for investigating new potential treatments [22, 23], In this study, LPS increased the immobility time of animals in the FST in comparison with the control group, in agreement with previous studies [24-28]. We also tested the animals for locomotor activity in the open field.…”

Section: Discussionsupporting

confidence: 89%

Evaluation of Brain Cytokines and the Level of Brain-Derived Neurotrophic Factor in an Inflammatory Model of Depression

Horita

Silva

Ferrari

et al. 2020

Neuroimmunomodulation

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Introduction: Major depressive disorder is considered a global public health problem. Inflammatory processes are likely involved in its pathophysiology, but the underlying mechanisms have remained uncertain.Here, we used the model of systemic lipopolysaccharide (LPS) injection to test the hypothesis that depressive-like behaviors occur along with changes in the levels of cytokines and brain-derived neurotrophic factor (BDNF) in the hippocampus (HC), prefrontal cortex (PFC), and hypothalamus (HT), and can be prevented by dexamethasone administration. Methods: Adult C57Bl/6 male mice were first isolated for 10 days, and thereafter received an injection of dexamethasone (6 mg/kg, intraperitoneal [i.p.]), saline followed by LPS (0.83 mg/kg, i.p.), or saline. After 6 h, animals were subjected to the forced-swim test (FST) and open-field tests. Immediately after the behavioral tests, they were euthanized and their brains were collected for the biochemical analyses. Results: LPS increased the immobility time and reduced the distance travelled in the FST and open-field test, respectively. Dexamethasone increased the immobility time in saline-treated mice but reduced this behavior in the LPS group. LPS increased the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and interferon (IFN)-γ in most of the regions evaluated. Dexamethasone prevented LPS-induced IL-6 in the HC, PFC, and HT. Interestingly, dexamethasone increased IL-4 and IL-10 levels in both the LPS- and saline-treated groups. Although dexamethasone reduced BDNF in saline-treated mice, it prevented LPS-induced reduction in this neurotrophic factor. Conclusion: In summary, dexamethasone decreased proinflammatory and increased anti-inflammatory levels of cytokines and prevented a reduction in BDNF levels induced by the inflammatory stimulus. Thus, the attenuation of depressive-like behavior induced by dexamethasone may be related to the effects on these parameters.

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Section: Discussionsupporting

confidence: 89%

Evaluation of Brain Cytokines and the Level of Brain-Derived Neurotrophic Factor in an Inflammatory Model of Depression

Horita

Silva

Ferrari

et al. 2020

Neuroimmunomodulation

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“…The monoaminergic system is still the major target of drugs used to treat affective disorders including MDD and anxiety (Artigas, 2013; Artigas, Bortolozzi, & Celada, 2018; Farb & Ratner, 2014; Perez‐Caballero et al, 2019). Moreover, DA nuclei such as the VTA (Berke, 2018; Bromberg‐Martin, Matsumoto, & Hikosaka, 2010; Ikemoto, 2007; Lammel, Lim, & Malenka, 2014; Salamone & Correa, 2012; Schultz, 2002), and 5‐HT cell groups such as the DR (Kranz, Kasper, & Lanzenberger, 2010; Liu et al, 2014; Nakamura, 2013) play key roles in the domains of reward/aversion and motivation.…”

Section: Introductionmentioning

confidence: 99%

Habenular connections with the dopaminergic and serotonergic system and their role in stress‐related psychiatric disorders

Metzger

Souza

Lima

et al. 2019

Eur J of Neuroscience

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The habenula (Hb) is a phylogenetically old epithalamic structure differentiated into two nuclear complexes, the medial (MHb) and lateral habenula (LHb). After decades of search for a great unifying function, interest in the Hb resurged when it was demonstrated that LHb plays a major role in the encoding of aversive stimuli ranging from noxious stimuli to the loss of predicted rewards. Consistent with a role as an anti-reward center, aberrant LHb activity has now been identified as a key factor in the pathogenesis of major depressive disorder. Moreover, both MHb and LHb emerged as new players in the reward circuitry by primarily mediating the aversive properties of distinct drugs of abuse. Anatomically, the Hb serves as a bridge that links basal forebrain structures with monoaminergic nuclei in the mid-and hindbrain. So far, research on Hb has focused on the role of the LHb in regulating midbrain dopamine release. However, LHb/MHb are also interconnected with the dorsal (DR) and median (MnR) raphe nucleus. Hence, it is conceivable that some of the habenular functions are at least partly mediated by the complex network that links MHb/LHb with pontomesencephalic monoaminergic nuclei. Here, we summarize research about the topography and transmitter phenotype of the reciprocal connections 66 | METZGER ET al. 1 | INTRODUCTION Major depressive disorder (MDD) is a multifaceted disorder (Belmaker & Agam, 2008; Pizzagalli, 2014) that affected about 322 million people worldwide in 2017 (World Health Organization/WHO, 2017). MDD is characterized by low mood, lack of motivation, feelings of despair, and anhedonia-a reduced ability to experience pleasure (Willner, Scheel-Kruger, & Belzung, 2013). Importantly, MDD is highly comorbid with anxiety and addictive disorders (Swendsen et al., 2010), and it has been postulated that these disorders are closely related, as they are all characterized in part by disarrangements in the reward circuitry (Eshel & Roiser, 2010; Russo & Nestler, 2013). A relative new player in the pathogenesis of MDD, as well as in the reward circuitry, is the habenula (Hb), which interestingly now is considered not only to be involved in aversive mood states such as MDD and anxiety (

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“…The role of genes as risk factors in this field is often discussed because of the complicated etiology and pathological mechanism of depression [7,8]. Monoaminergic and glutamatergic systems have been shown to inhibit depression [9][10][11]. Meanwhile, numerous psychosocial risk factors associated with depression have been identified.…”

Section: Introductionmentioning

confidence: 99%

A Large Sample Survey of Tibetan People on the Qinghai–Tibet Plateau: Current Situation of Depression and Risk Factors

Wang

Zhou

Liang

et al. 2019

IJERPH

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Background: A depressive state is a negative emotional state characterized by abnormal dejection and unpleasant mood. Long-term depressive symptoms can result in psychological disorders such as depression. However, little is known about the depression status and risk factors of the Tibetan people on the Qinghai–Tibet Plateau. Objective: This study explores the depression status of the Tibetan people to better promote ethnic minorities’ physical and mental health. Participants and Setting: The Center for Epidemiologic Studies Depression Scale (CES-D) was administered to 24,141 Tibetan people from Yushu Prefecture; the average age was 34.33 years (SD = 9.18, range = 18–94 years). Materials and Methods: Participants completed questionnaires collecting demographic information and evaluating symptoms of depression. Results: The depression prevalence was higher at high altitudes, and there may be a significant positive correlation between depression rates and altitude. Significant differences were found for each demographic variable. Participants with depressive symptoms (scores ≥8) accounted for 52.3% of the total sample, and participants with depression (scores ≥14) accounted for 28.6%. The binary logistic regression results showed that alcohol drinkers, unmarried participants, participants with high self-assessed socioeconomic status, participants with a high income level, and those with a middle-school education were more likely to be depressed. Conclusions: The results provide the first evidence that the prevalence of depression in Tibetans of the Qinghai–Tibet Plateau is higher than that in the general Chinese population and that reported in Western studies, a finding that may be related to cultural differences and chronic hypoxia caused by the high altitude. This paper offers insight into the mental health status of people living in plateau areas and provides a basis for formulating pertinent mental health policy.

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Monoaminergic system and depression

Cited by 140 publications

References 42 publications

Evaluation of Brain Cytokines and the Level of Brain-Derived Neurotrophic Factor in an Inflammatory Model of Depression

Evaluation of Brain Cytokines and the Level of Brain-Derived Neurotrophic Factor in an Inflammatory Model of Depression

Habenular connections with the dopaminergic and serotonergic system and their role in stress‐related psychiatric disorders

A Large Sample Survey of Tibetan People on the Qinghai–Tibet Plateau: Current Situation of Depression and Risk Factors

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