Monoamines activate neuropeptide signaling cascades to modulate nociception in C. elegans: a useful model for the modulation of chronic pain?

Komuniecki, Rick; Harris, Graham P.; Hapiak, Vera; Wragg, Rachel T.; Bamber, Bruce A.

doi:10.1007/s10158-011-0127-0

Cited by 25 publications

(15 citation statements)

References 58 publications

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“…Recent insights into more complex locomotion behaviors [70,71], the orchestration of sequential behaviors [16 ,62 ,63,64], and the variety of modulation pathways [71,72] suggest that extrasynaptic circuit mechanisms should be given more prominence in future models. Indeed what emerges is a much richer view of the C. elegans nervous system, as a dynamic, reconfigurable and overlaid circuit, in which neuronal-environmental loops act in a variety of mechanisms across a wide range of time scales.…”

Section: Discussionmentioning

confidence: 99%

Nematode locomotion: dissecting the neuronal–environmental loop

Cohen

Sanders

2014

Current Opinion in Neurobiology

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With a fully reconstructed and extensively characterized neural circuit, the nematode Caenorhabditis elegans is a promising model system for integrating our understanding of neuronal, circuit and whole-animal dynamics. Fundamental to addressing this challenge is the need to consider the tight neuronal-environmental coupling that allows the animal to survive and adapt to changing conditions. Locomotion behaviors are affected by environmental variables both at the biomechanical level and via adaptive sensory responses that drive and modulate premotor and motor circuits. Here we review significant advances in our understanding of proprioceptive control of locomotion, and more abstract models of spatial orientation and navigation. The growing evidence of the complexity of the underlying circuits suggests that the intuition gained is but the first step in elucidating the secrets of neural computation in this relatively simple system. http://dx.doi.org/10. 1016/j.conb.2013.12.003 Introduction To survive, animals process sensory information to drive motor behaviors and to move about their environment. Among locomotion strategies, undulations are remarkably effective across scales and in a variety of environments [1][2][3]. Common to most locomotion and to undulationbased strategies, in particular, is the tight neuronalenvironmental loop, in which the shape of the body and the way in which the sensory organs sample the environment are integral to the neural dynamics. The nematode Caenorhabditis elegans (C. elegans) is a powerful system in which to study this loop, due to its small nervous system and experimental tractability. Indeed, with a largely specified neural circuit and rapidly advancing technologies for recording and manipulating neuronal activity [4 ,5], significant progress is being made in deciphering the dynamics this neural circuit supports.Here we review recent progress in understanding the motor programs underpinning undulatory locomotion as well as higher level command of locomotion primitives and sensorimotor programs in C. elegans. We discuss how progress in understanding the neuronal-environmental loop is contributing to the ongoing effort and fundamental challenges in assembling a whole animal model of C. elegans behavior. The ventral nerve cordC. elegans is a small (1 mm long) unsegmented worm with 302 nerve cells [6][7][8]. The animal's undulations are controlled by head and ventral nerve cord (VNC) circuits. Extensive characterization of defects (through ablation of individual classes of neurons) [9][10][11] has provided a strong basis for an intuitive understanding of the operation of this otherwise irregular circuit architecture [12 ,13]. Indeed, evidence suggests that semi-independent VNC subcircuits control forward and backward locomotion [6,14,15,16 ,17 ,18 ,19 ] and are gated by distinct premotor (so-called command) interneurons. The forward locomotion circuit in the ventral nerve cordIn forward locomotion, cholinergic motor neurons excite muscles on either side of the body while ...

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Section: Discussionmentioning

confidence: 99%

Nematode locomotion: dissecting the neuronal–environmental loop

Cohen

Sanders

2014

Current Opinion in Neurobiology

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“…Further analysis has broadened the modulatory inputs to encompass dopamine, tyramine, and octopamine, as well as numerous neuropeptides 21, 22. These amines and peptides are produced by a variety of neurons, and interact through mutually antagonistic relationships 23. To a first approximation, the neuromodulators appear to switch the circuit between two alternative functional states: one driven by ASH alone, and one driven by ASH, AWB, and ADL.…”

Section: The C Elegans Connectome: Simple Anatomy Surprising Functimentioning

confidence: 99%

Beyond the connectome: How neuromodulators shape neural circuits

2012

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Powerful ultrastructural tools are providing new insights into neuronal circuits, revealing a wealth of anatomically-defined synaptic connections. These wiring diagrams are incomplete, however, because functional connectivity is actively shaped by neuromodulators that modify neuronal dynamics, excitability, and synaptic function. Studies of defined neural circuits in crustaceans, C. elegans, Drosophila, and the vertebrate retina have revealed the ability of modulators and sensory context to reconfigure information processing by changing the composition and activity of functional circuits. Each ultrastructural connectivity map encodes multiple circuits, some of which are active and some of which are latent at any given time.

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“…The biomarker lists generated by the software were analyzed using the WormBase SimpleMine database, which provides high-throughput descriptions of gene function and tissue-specific expression. Several genes were identified which provide anatomical, biochemical, and genetic information about the cell type clusters supported by the literature (Tomaselli, Reichardt et al 1986, Way and Chalfie 1989, Way, Wang et al 1991, Gendreau, Moskowitz et al 1994, Wang and Way 1996, Tavernarakis, Shreffler et al 1997, Duggan, Ma et al 1998, Koh and Rothman 2001, Jia, Chen et al 2004, Fukushige, Brodigan et al 2006, Smit, Schnabel et al 2008, Barrios, Ghosh et al 2012, Frooninckx, Van Rompay et al 2012, Goodwin, Sasaki et al 2012, Komuniecki, Harris et al 2012, Sasidharan, Sumakovic et al 2012, Jedrusik-Bode 2013, Towlson, Vertes et al 2013, Ackley 2014, Ortiz, Noble et al 2014, Peymen, Watteyne et al 2014, Burdick, Walton et al 2016, Kaletsky, Yao et al 2018.…”

Section: Cell Type Determination and Biomarker Discoverymentioning

confidence: 88%

Organism-wide single-cell transcriptomics of long-livedC. elegans daf-2^-/-mutants reveals tissue-specific reprogramming of gene expression networks

Preston

Stiffler

Weitzman

2019

Preprint

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A critical requirement for a systems-level understanding of complex biological processes such as aging is the ability to directly characterize interactions between cells and tissues within a multicellular organism. C. elegans nematodes harboring mutations in the insulinlike receptor daf-2 exhibit dramatically-increased lifespans. To identify tissue-specific biochemical mechanisms regulating aging plasticity, we single-cell sequenced 3'-mRNA libraries generated from seven populations of whole day-one adult wild-type and daf-2 -/-

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Monoamines activate neuropeptide signaling cascades to modulate nociception in C. elegans: a useful model for the modulation of chronic pain?

Cited by 25 publications

References 58 publications

Nematode locomotion: dissecting the neuronal–environmental loop

Nematode locomotion: dissecting the neuronal–environmental loop

Beyond the connectome: How neuromodulators shape neural circuits

Organism-wide single-cell transcriptomics of long-livedC. elegans daf-2^-/-mutants reveals tissue-specific reprogramming of gene expression networks

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Monoamines activate neuropeptide signaling cascades to modulate nociception in C. elegans: a useful model for the modulation of chronic pain?

Cited by 25 publications

References 58 publications

Nematode locomotion: dissecting the neuronal–environmental loop

Nematode locomotion: dissecting the neuronal–environmental loop

Beyond the connectome: How neuromodulators shape neural circuits

Organism-wide single-cell transcriptomics of long-livedC. elegans daf-2-/-mutants reveals tissue-specific reprogramming of gene expression networks

Contact Info

Product

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Organism-wide single-cell transcriptomics of long-livedC. elegans daf-2^-/-mutants reveals tissue-specific reprogramming of gene expression networks