Monoarthrite du genou à Neisseria meningitidis sans méningite : apport de la culture du liquide articulaire en flacon d’hémoculture

Cartolano, Gian-Luigi; Lostec, Z Le; Cheron, Mireille; Boisivon, A; Welker, Yves; Mornet, Patrick

doi:10.1016/s0248-8663(00)00289-7

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…According to Barahona et al [1], PMA is considered a rare entity, accounting for 1.5–1.8% of all pediatric cases of pyogenic arthritis isolated by synovial fluid culture [17]. To our knowledge, less than 50 cases are described in the literature, combining adult and pediatric patients [1–7, 17, 18]. PMA is defined as the presence of septic arthritis without meningeal signs or meningococcaemia and the detection of N. meningitidis in synovial fluid and/or blood analysis.…”

Section: Discussionmentioning

confidence: 99%

“…It is clinically impossible to differentiate PMA from other types of septic arthritis. Synovial fluid culture and molecular tests are pivotal the confirmation of PMA [1–7]. We discuss two PMA cases diagnosed by Real Time Polymerase Chain Reaction (RT-PCR) following the admission in our hospital of two children in January and March 2017, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Is primary meningococcal arthritis in children more frequent than we expect? Two pediatric case reports revealed by molecular test

et al. 2018

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BackgroundPrimary meningococcal arthritis is a rare infectious disease that occurs in less than 3% of meningococcal infections and is characterized by arthritis without meningitis, fever, rash, or hemodynamic instability Barahona [Case Rep Orthop 4696014:2017 ]. There are no validated clinical criteria that can be used for the diagnosis. We present two pediatric cases of atypical presentation of meningococcal disease revealed by molecular tests.Case presentationThe clinical presentation of the two children (6- and 9-years-old) was characterized by signs of arthritis. By Real Time Polymerase Chain Reaction (RT-PCR), we identified N. meningitidis serogroup Y in the joint fluid in both cases. After specific antimicrobial treatment, the clinical conditions of the two patients quickly improved during hospitalization. Conclusions. We believe that the incidence of meningococcal arthritis could be underestimated in those settings where the use of RT-PCR is limited. Clearer data on the incidence of meningococcal disease would help to design specific treatments and the best possible national vaccine strategies [Fiji Sci Rep 23:39784, 2016, J Infect 67:385-90, 2013].

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is primary meningococcal arthritis in children more frequent than we expect? Two pediatric case reports revealed by molecular test

et al. 2018

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Primäre Meningokokkeninfektion des Kniegelenks

Lehmann

Rueger

2015

Unfallchirurg

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This article presents a case of primary septic arthritis of the knee due to serogroup C Neisseria meningitidis. A 19-year-old female presented to the emergency department with a painless but swollen knee joint which had started 2 days previously and fever (38 °C). The patient reported that she suddenly felt unwell 3 days ago and developed a rush at the same time which had almost disappeared when arrived at the emergency department. The patient was admitted to hospital and an antibiotic therapy was started with sulbactam and ampicillin. Initially, incubation of synovial fluid over the next 3 days did not result in detection of any pathogens; therefore, a reactive arthritis was assumed until Neisseria meningitidis was detected in cultures of the synovial fluid. Therapy was then switched to antibiotic therapy with ceftriaxon and arthroscopic irrigation was performed. The patient quickly recovered and was discharged from hospital after 14 days. This case example shows the difficulties of the clinical and microbiological diagnostics of a primary septic meningococcal arthritis; however, the treatment is relatively easy and mostly successful compared to other forms of bacterial joint infection.

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Monoarthrite primitive isolée du genou à Neisseria meningitidis B sans méningite

Nicolás

Guen

Graníer

et al. 2006

La Revue de Médecine Interne

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Monoarthrite du genou à Neisseria meningitidis sans méningite : apport de la culture du liquide articulaire en flacon d’hémoculture

Cited by 8 publications

References 11 publications

Is primary meningococcal arthritis in children more frequent than we expect? Two pediatric case reports revealed by molecular test

Is primary meningococcal arthritis in children more frequent than we expect? Two pediatric case reports revealed by molecular test

Primäre Meningokokkeninfektion des Kniegelenks

Monoarthrite primitive isolée du genou à Neisseria meningitidis B sans méningite

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