2019
DOI: 10.1101/686832
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Monocarboxylate transporter 1 in Schwann cells is critical for maintenance of sensory nerve myelination during aging

Abstract: Word count: 11,155 (Abstract: 130 and Main Text: 7,171) Abstract Schwann cell (SC)-specific monocarboxylate transporter 1 (MCT1) knockout mice were generated by mating MCT1 f/f mice with myelin protein zero (P0)-Cre mice. P0-Cre +/-, MCT1 f/f mice have no detectable early developmental defects, but develop hypomyelination and reduced conduction velocity in sensory, but not motor, peripheral nerves during maturation and aging. Furthermore, enlarged node length and reduced mechanical sensitivity were evident … Show more

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