2002
DOI: 10.1186/1751-0147-43-63
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Monocarboxylate Transporters and Lactate Metabolism in Equine Athletes: A Review

Abstract: Pösö AR: Monocarboxylate transporters and lactate metabolism in equine athletes: A review. Acta vet. scand. 2002, 43, 63-74. -Lactate is known as the end product of anaerobic glycolysis, a pathway that is of key importance during high intensity exercise. Instead of being a waste product lactate is now regarded as a valuable substrate that significantly contributes to the energy production of heart, noncontracting muscles and even brain. The recent cloning of monocarboxylate transporters, a conserved protein fa… Show more

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Cited by 31 publications
(3 citation statements)
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“…Lactate is known as the end product of anaerobic glycolysis, a pathway that is of key importance during normal metabolic and athletic events. Aside being a waste product during high intensity exercise, lactate is also a valuable substrate that significantly contributes to the energy production of heart, liver, kidneys, non-contracting muscles and even brain [ 34 ]. In the present study, lactate concentration decreased during the 4 h (T1-T4) post-injection of digoxin, and this may have been caused by the decrease in the metabolic index due to the inactivity of the animals during these time points.…”
Section: Discussionmentioning
confidence: 99%
“…Lactate is known as the end product of anaerobic glycolysis, a pathway that is of key importance during normal metabolic and athletic events. Aside being a waste product during high intensity exercise, lactate is also a valuable substrate that significantly contributes to the energy production of heart, liver, kidneys, non-contracting muscles and even brain [ 34 ]. In the present study, lactate concentration decreased during the 4 h (T1-T4) post-injection of digoxin, and this may have been caused by the decrease in the metabolic index due to the inactivity of the animals during these time points.…”
Section: Discussionmentioning
confidence: 99%
“…It is well known that the lactic acid level is used in practice to evaluate the fitness of racehorses and used as an indicator of racing performance (Harkins et al, 1993;Lindner, 2000). The changes in the rate of the LA production by muscles, reflect the degree at which anaerobic glycolysis contributes to the total energy production (Pösö, 2002) and the decline in blood lactate concentration reflects the cessation of exercise in chronic tendinitis horses due to the tendon injury. The lower values of icteric index reported in tendinitis than the normal horses may be attributed to the.interference with biochemistry assays due to haemolysis, icterus or lipaemia (HIL) which is a common problem in clinical laboratory practice which is measured by icteric index (Simundic et al, 2009;Adiga, 2016;Farrell et al, 2016).…”
Section: Discussionmentioning
confidence: 99%
“…In exercise the blood lactate concentrations are expected to increase in these horses. The level of blood lactate in the horse is used as a measure of performance and fatigue (Pösö, 2002;Letafatkar et al, 2009). It has been shown, in exercise blood lactate concentrations increase, but the levels seldom exceed 4 mmol L −1 even in sick horses.…”
Section: Km) --------------------------------------------------------mentioning
confidence: 99%