Monochromatic excimer light (308 nm): an immunohistochemical study of cutaneous T cells and apoptosis‐related molecules in psoriasis

Abstract

These results indicate that psoriatic skin after monochromatic excimer light therapy is associated with significant T-cell depletion and alterations of apoptosis-related molecules accompanied by a decreased proliferation index and clinical remission.

Targeted UV-B Phototherapy for Plaque-type Psoriasis

“…The therapeutic effect of targeted UV-B phototherapy should be similar to that of broadband UV-B, 10 narrowband UV-B, 11 and 308-nm excimer laser, 12 whereby apoptosis of infiltrating lymphocytes and reduction in proliferation of keratinocytes are the main mechanisms of action.…”

Targeted phototherapy

“…The decrease of pruritus after treatment with both BB-UVB and NB-UVB is caused by cell mast apoptosis [11]. In the use of targeted BBUVB phototherapy, NBUVB and excimer laser, T cell apoptosis was found [12][13][14]. The apoptosis mechanism may be caused by the damage of the epidermis and dermis cells, which are susceptible to UV light exposure.…”

Treatment of Folliculitis with Monochromatic Excimer Light (308 nm)

“…Recent papers suggest that 308-nm monochromatic excimer light (MEL) may induce clinical remission in inflammatory skin possibly by the decrease in cytokine expression [4]. In addition, the efficacy of MEL in psoriatic skin is associated with significant T cell depletion and alteration in apoptosis-related molecules, accompanied by a decreased proliferation index and clinical remission [4].…”

“…In addition, the efficacy of MEL in psoriatic skin is associated with significant T cell depletion and alteration in apoptosis-related molecules, accompanied by a decreased proliferation index and clinical remission [4]. These hypothetic mechanisms of action are similar to those described following narrow-band UVB and suggest the application of MEL in other inflammatory skin diseases.…”