Monoclonal Antibodies in the Diagnosis of Hodgkinʼs Disease

Chittal, Shashikant; Caverivière, P.; Schwarting, Roland; Gerdes, Johannes; Saati, Talal Al; Rigal‐Huguet, Françoise; Stein, H; Delsol, Georges

doi:10.1097/00000478-198801000-00002

Cited by 173 publications

(64 citation statements)

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“…As found in this study, ALC lymphomas, more often than not, show CD30 +, EMA +, BNH9 + phenotype whereas typical Reed-Sternberg cells in HD most frequently co-express CD15 and CD30 antigens (Chittal et al, 1988). EMA is not expressed by classic ReedStemnberg cells (Chittal et al, 1988). Similarly, we found the antigens detected by BNH9 antibody to be expressed rarely by Reed-Sternberg cells in HD (Table II).…”

Section: Adsorption With Synthetic Oligosaccharidessupporting

confidence: 83%

Antibody BNH9 detects red blood cell-related antigens on anaplastic large cell (CD30+) lymphomas

Delsol

Blancher²,

Saati³

et al. 1991

Br J Cancer

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Section: Adsorption With Synthetic Oligosaccharidessupporting

confidence: 83%

Antibody BNH9 detects red blood cell-related antigens on anaplastic large cell (CD30+) lymphomas

Delsol

Blancher²,

Saati³

et al. 1991

Br J Cancer

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“…Indeed, a previously published gene expression study comparing the gene expression profiles of tumor cells of different B cell lymphomas reported that tumor cells of THRLBCL were most closely related to tumor cells of typical nodular NLPHL [13]. However, THRLBCL-like NLPHL was not included in the analysis, nor in other studies, which aimed to identify differentially expressed markers between the two entities [30,31,32,33]. So far, many commonly expressed genes in tumor cells of both entities were identified, such as BCL6, CD75, EMA, J-chain and PU.1, as well as a typical kappa light chain restriction [11,34,35,36,37].…”

Section: Discussionmentioning

confidence: 99%

Nodular Lymphocyte Predominant Hodgkin Lymphoma and T cell/Histiocyte Rich Large B Cell Lymphoma Endpoints of a Spectrum of one Disease?

Hartmann¹,

Döring²,

Jakobus³

et al. 2014

Klin Padiatr

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In contrast to the commonly indolent clinical behavior of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), T cell/histiocyte rich large B cell lymphoma (THRLBCL) is frequently diagnosed in advanced clinical stages and has a poor prognosis. Besides the different clinical presentations of these lymphoma entities, there are variants of NLPHL with considerable histopathologic overlap compared to THRLBCL. Especially THRLBCL-like NLPHL, a diffuse form of NLPHL, often presents a histopathologic pattern similar to THRLBCL, suggesting a close relationship between both lymphoma entities. To corroborate this hypothesis, we performed gene expression profiling of microdissected tumor cells of NLPHL, THRLBCL-like NLPHL and THRLBCL. In unsupervised analyses, the lymphomas did not cluster according to their entity. Moreover, even in supervised analyses, very few consistently differentially expressed transcripts were found, and for these genes the extent of differential expression was only moderate. Hence, there are no clear and consistent differences in the gene expression of the tumor cells of NLPHL, THRLBCL-like NLPHL and THRLBCL. Based on the gene expression studies, we identified BAT3/ BAG6, HIGD1A, and FAT10/UBD as immunohistochemical markers expressed in the tumor cells of all three lymphomas. Characterization of the tumor microenvironment for infiltrating T cells and histiocytes revealed significant differences in the cellular composition between typical NLPHL and THRLBCL cases. However, THRLBCL-like NLPHL presented a histopathologic pattern more related to THRLBCL than NLPHL. In conclusion, NLPHL and THRLBCL may represent a spectrum of the same disease. The different clinical behavior of these lymphomas may be strongly influenced by differences in the lymphoma microenvironment, possibly related to the immune status of the patient at the timepoint of diagnosis.

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“…The presence of Reed-Sternberg (R-S) cells with extensive or limited membrane or cytoplasmic CD15 and CD30 immunoreactivity in a lesion with polytypic T and B lymphocytes and eosinophils supports a diagnosis of HD. 45 In contrast to lymphoplasmacytic meningiomas, HD displays no identifiable meningothelial component with EMA immunostaining. The tumor has no granulomas asteroid or Schaumann bodies of neurosarcoidosis.…”

Section: Hodgkin's Diseasementioning

confidence: 99%

Dural lesions mimicking meningiomas

et al. 2002

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Recently, a number of neoplastic and nonneoplastic entities have been reported that radiographically and clinically mimic meningiomas. Because these lesions occur infrequently and may resemble a meningioma during intraoperative analysis, they may not be considered in the differential diagnosis. This review (and case illustrations) considers some of the newly recognized and notable lesions that can mimic meningiomas, including solitary fibrous tumors, gliosarcomas, leiomyosarcomas, hemangiopericytomas, melanocytomas, Hodgkin's disease, plasmacytomas, inflammatory pseudotumors, neurosarcoidosis, plasma cell granulomas, Rosai-Dorfman disease, Castleman's disease, xanthomas, rheumatoid nodules, and tuberculomas. Awareness that these lesions involve the dura may facilitate intraoperative recognition and, in some cases, preclude unnecessary additional surgery. HUM PATHOL 33:1211-1226.

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Monoclonal Antibodies in the Diagnosis of Hodgkinʼs Disease

Cited by 173 publications

References 0 publications

Antibody BNH9 detects red blood cell-related antigens on anaplastic large cell (CD30+) lymphomas

Antibody BNH9 detects red blood cell-related antigens on anaplastic large cell (CD30+) lymphomas

Nodular Lymphocyte Predominant Hodgkin Lymphoma and T cell/Histiocyte Rich Large B Cell Lymphoma Endpoints of a Spectrum of one Disease?

Dural lesions mimicking meningiomas

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