Monoclonal Antibody-Based Enzyme Immunoassay for Trypsinogen in Neonatal Screening for Cystic Fibrosis

Bowling, Francis; Rylatt, Dennis B.; Bunch, R. J.; Watson, Avia; Elliott, Janet; Bundesen, Peter

doi:10.1016/s0140-6736(87)91607-2

Cited by 19 publications

(5 citation statements)

References 10 publications

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“…IRT also is used in the assessment of exocrine pancreatic function. It is in widespread use in neonatal screening for CF because IRT levels are elevated in infancy (4). IRT levels fall after 1 year of age and after the age of 7 are in the subnormal range in PI patients.…”

mentioning

confidence: 99%

Exocrine Pancreatic Function Testing in Patients With Cystic Fibrosis and Pancreatic Sufficiency: A Correlation Study

Weintraub¹,

Blau²,

Mussaffi³

et al. 2009

J. pediatr. gastroenterol. nutr.

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mentioning

confidence: 99%

Exocrine Pancreatic Function Testing in Patients With Cystic Fibrosis and Pancreatic Sufficiency: A Correlation Study

Weintraub¹,

Blau²,

Mussaffi³

et al. 2009

J. pediatr. gastroenterol. nutr.

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“…lia, since December 1982 (4,5), and we (5,6) and others (7) have reported that significant nutritional abnormalities are apparent at a very early age in cystic fibrosis and that even in the absence of significant chest disease, CF infants demonstrate significantly higher total energy expenditure than do control infants (6).…”

mentioning

confidence: 69%

“…Neonatal Screening for CF Since December 1982, 99.9 % of newborns in Queensland have been screened for CF by immunoassay of dried blood spot (4,5). Infants with elevated levels of trypsinogen are recalled for a second test at 3-4 weeks of age, and those with persistently elevated levels have at least two sweat chloride estimations for confirmation of the diagnosis of cystic fibrosis.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Growth and Changes in Body Composition Following Neonatal Diagnosis of Cystic Fibrosis

Greer,

Shepherd,

Cleghorn

et al. 1991

J. pediatr. gastroenterol. nutr.

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SummaryEarly deficits in nutritional status that might require specific treatment and early response to nutritional therapy were studied longitudinally in 25 infants with cystic fibrosis (CF) diagnosed by neonatal screening, using anthropometric and research body composition methodology, and evaluation of pancreatic function. At the time of confirmed diagnosis (mean 5.4 weeks), body mass, length, total body fat (TBF), and total body potassium (TBK) were all significantly reduced. Following diagnosis and commencement of therapy there was a normalization of weight, length, and TBK by 6–12 months of age, indicating catch‐up growth. But in some individuals the response was incomplete, and as a group, mean total body fat remained significantly lower than normal at 1 year of age. Seven of 25 (28%) were pancreatic sufficient at diagnosis, and all but one had evidence of declining pancreatic function requiring the institution of pancreatic enzyme therapy during the next 1–9 months. The median age of commencement of enzyme therapy was 10 weeks (range 5 weeks to 11 months). These longitudinal assessments emphasize the dynamic changes occurring in absorptive function, body composition, and nutritional status following neonatal diagnosis of cystic fibrosis and may reflect previously described abnormalities of energy metabolism in this age group. Abnormal body composition is evident in most CF infants following diagnosis by neonatal screening but pancreatic damage may still be evolving. We suggest that early active nutritional therapy and surveillance for changes in pancreatic function are warranted in CF infants diagnosed by neonatal screening.

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“…Age was positively cationic trypsinogen content using an enzyme-linked immunocorrelated with mid upper arm circumference (r=0.743), but sorbent assay (ELISA) technique described elsewhere. 16 The not with the whole-blood IRT concentration (r=−0.158). The IRT concentration was expressed in mg/L.…”

Section: Mount Isa Studymentioning

confidence: 97%

Malnutrition, gastroenteritis and trypsinogen concentration in hospitalised Aboriginal children

Briars

Thornton²,

Forrest

et al. 1998

J Paediatrics Child Health

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Objective: To explore relationships between malnutrition and pancreatic damage in hospitalised aboriginal children. Methods: Immunoreactive trypsinogen (IRT) concentrations were measured in two populations of hospitalised aboriginal children in Australia: 472 children aged 0-3 years, in Alice Springs (Northern Territory); and 187 children aged 0-16 years in Mount Isa (Queensland). Correlation of whole blood IRT with height and weight z-scores, four-site skinfold thickness and upper arm circumference was sought. Results: In Mount Isa, the geometric mean IRT concentration rose with decreasing weight z-score. The IRT concentration was otherwise unrelated to nutritional indices. Sixty percent of the 39 Mount Isa patients with gastroenteritis and 24.5% of the 358 Alice Springs patients with gastroenteritis had an IRT concentration in the upper quartile for their population, compared with 16% for patients with other diagnoses in both populations. Conclusions: A high IRT concentration in patients with low weight z-scores is a confounding effect of gastroenteritis, and may result from subclinical pancreatic disease in gastroenteritis.

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Monoclonal Antibody-Based Enzyme Immunoassay for Trypsinogen in Neonatal Screening for Cystic Fibrosis

Cited by 19 publications

References 10 publications

Exocrine Pancreatic Function Testing in Patients With Cystic Fibrosis and Pancreatic Sufficiency: A Correlation Study

Exocrine Pancreatic Function Testing in Patients With Cystic Fibrosis and Pancreatic Sufficiency: A Correlation Study

Evaluation of Growth and Changes in Body Composition Following Neonatal Diagnosis of Cystic Fibrosis

Malnutrition, gastroenteritis and trypsinogen concentration in hospitalised Aboriginal children

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