2024
DOI: 10.22541/au.170667100.04888721/v1
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Monoclonal Antibody-Light chain CDR1/Spike Glycoprotein Receptor Binding Domain Dissociation Explains Antibody Escape Mechanism in L452R-SARS-CoV-2

olaposi omotuyi,
Oyekanmi Nash,
babatunji Oyinloye
et al.

Abstract: Most of the well-characterized innate antibodies elicited by exposure to SARS-CoV-2 or a vaccine targets the spike glycoprotein receptor-binding domain (RDB) which doubles as the angiotensin-converting enzyme 2 (ACE2, receptor) binding. RBD mutation is therefore a potential health concern in COVID-19 pandemic. RBD-L452R-SARS-CoV-2 exhibits increased transmissibility and immune evasion with an unknown underlying mechanisms. The immune evasion mechanism was investigated here. in R452, loss of hydrophobic interac… Show more

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