Monoclonal B cells and restricted oligoclonal T cells in T-cell-rich S-cell lymphoma

Ohshima, Kohichi; Y, Masuda; Kikuchi, Masahiro; Sumiyoshi, Yoshiaki; Kobari, Shinichi; Yoneda, Satoshi; Takeshita, Morishige; Kimura, N.

doi:10.1016/s0344-0338(11)80492-9

Cited by 10 publications

(13 citation statements)

References 35 publications

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“…The phenotype of these populations also suggests impaired immunosurveillance and raises the possibility that stimulation of the immune system may constitute an alternative therapy38. It has been reported that T‐cell families may be restricted in TCRBL12, but in our study the pattern of TCRB rearrangements was polyclonal, consistent with other reports in the literature7, 10, 11. TCRG rearrangements were observed in two cases.…”

Section: Discussionsupporting

confidence: 90%

“…Molecular studies of DNA isolated from tumour biopsies and isolated tumour cells suggest that IgH genes are clonally rearranged in the majority of TCRBL cases10–15. PCR can be applied to poor quality DNA for amplification of products less than 300 bp but has the disadvantage of limited primer homology to all V gene sequences, which can lead to false‐negative results.…”

Section: Discussionmentioning

confidence: 99%

“…While the pathogenesis of TCRBL remains uncertain, Southern blot analysis of DNA extracted from tumour biopsies suggests that IgH genes are rearranged in the majority of cases10–12. These studies have been confirmed by polymerase chain reaction (PCR) amplification of DNA from a small number of cases in which the IgH genes were somatically mutated13–15.…”

Section: Introductionmentioning

confidence: 92%

“…It is not known whether these infiltrates may be attracted by the display of viral antigens by neoplastic B cells, for example, in association with Epstein–Barr virus (EBV) and there are few data concerning the role of EBV in TCRBL17. The B‐cell population in TCRBL may elicit an oligoclonal/restricted cell response12 as has been described in B chronic lymphocytic leukaemia (B‐CLL), myeloma, and immunoblastic B‐cell lymphoma18.…”

Section: Introductionmentioning

confidence: 99%

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Molecular analysis reveals somatically mutated and unmutated clonal and oligoclonal B cells in T-cell-rich B-cell lymphoma

Hodges¹,

Hamid

Quin³

et al. 2000

J. Pathol.

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This paper describes the immunohistology and molecular genetics of 18 cases of T-cell-rich B-cell lymphoma (TCRBL). In all cases, the large B cells stained strongly for CD20, with more variable expression of CD79a, and were negative for CD30 and CD15. The majority of T cells were predominantly positive for TIA-1 and negative for CD57; a large population of histiocytes was present in all cases. Epstein-Barr virus (EBV)-coded RNA (EBER) was found in B blasts from four cases and in one case was present among the background lymphoid cells. IgH PCR products were generated in 16/18 cases and revealed clonal, oligoclonal and polyclonal PCR products in 12, two and two cases, respectively. In addition, TCRG clonal gene rearrangements were identified in two cases. TCRB gene rearrangements were polyclonal. Sequence analysis of seven cases with clonal/oligoclonal IgH gene rearrangements revealed functional sequences with predominant V(H)3 gene usage associated with various D genes and J(H)4 or J(H)6 gene segments. Four cases displayed varying degrees of replacement and silent mutations (1.8-21%), with one case exhibiting intraclonal heterogeneity; the distribution of mutations was indicative of antigen selection in three cases. The remaining three cases, including two cases with functional oligoclonal IgH rearrangements, harboured unmutated V region genes. The EBV-positive cases were associated with clonal, oligoclonal and polyclonal PCR products and with mutated and germline clonal sequences. These data indicate that TCRBL may be a heterogeneous entity associated with clonal and oligoclonal B cells derived from both germinal centre and naïve B cells.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Molecular analysis reveals somatically mutated and unmutated clonal and oligoclonal B cells in T-cell-rich B-cell lymphoma

Hodges¹,

Hamid

Quin³

et al. 2000

J. Pathol.

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“…Reports of BM involvement at presentation range from 0% 6 to 67% 7 ; BM involvement has not been fully described previously. The p r e s e n t s t u d y focuses on the histopathologic features of the BM in 13 cases of TCR-BCL, with emphasis on the differentiation from morphologically similar entities and its possible relationship to diffuse LPHD and HRBCL.…”

mentioning

confidence: 96%

Bone Marrow Involvement in T-Cell–Rich B-Cell Lymphoma

1997

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T-cell-rich large B-cell lymphoma in children and adolescents

Lones

Cairo

Perkins

2000

Cancer

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BACKGROUND T‐cell–rich large B‐cell lymphoma (TCRLBCL) is a morphologic subset of diffuse large B‐cell lymphoma that has been confused with Hodgkin disease and reactive lymphadenopathies. To the authors' knowledge the majority of reports of TCRLBCL are from adults, and it is not widely recognized as occurring in the pediatric population. The current study reports a cohort of six cases of TCRLBCL from the Children's Cancer Group CCG‐5961 study. METHODS Biopsies from patients entered on CCG‐5961 were submitted for central pathology review and immunophenotyping. Six cases of TCRLBCL were identified and correlated with clinical characteristics. RESULTS Of 86 cases centrally reviewed to date on CCG‐5961, 20 (23%) were diagnosed as diffuse large B‐cell lymphomas. Of these, 6 cases (7% of total cases and 30% of large B‐cell cases) were TCRLBCL, based on a diffuse growth pattern with a minor population of neoplastic large B cells and an associated extensive reactive T‐cell infiltrate. All patients with TCRLBCL were males ages 12–16 years. Three patients with TCRLBCL had advanced stage disease. No bone marrow or central nervous system involvement was detected in any case. CONCLUSIONS TCRLBCL is a morphologic subtype of diffuse large B‐cell lymphoma that may be difficult to recognize due to the extensive infiltrate of reactive T cells. This entity is not well recognized in pediatric patients, but in the current study represented 7% of all cases and 30% of large B‐cell lymphomas received for central review from the ongoing CCG‐5961 protocol. Because TCRLBCL may be confused with Hodgkin disease and reactive lymphadenopathies, it is essential that this entity be recognized in the pediatric age group. Cancer 2000;88:2378–86. © 2000 American Cancer Society.

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Monoclonal B cells and restricted oligoclonal T cells in T-cell-rich S-cell lymphoma

Cited by 10 publications

References 35 publications

Molecular analysis reveals somatically mutated and unmutated clonal and oligoclonal B cells in T-cell-rich B-cell lymphoma

Molecular analysis reveals somatically mutated and unmutated clonal and oligoclonal B cells in T-cell-rich B-cell lymphoma

Bone Marrow Involvement in T-Cell–Rich B-Cell Lymphoma

T-cell-rich large B-cell lymphoma in children and adolescents

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