Monoclonal gammapathies in long-term surviving Rhesus monkeys after lethal irradiation and bone marrow transplantation

Rádl, J.; Liu, M.; Hoogeveen, C.M.; Berg, P van den; Minkman-Brondijk, R.J.; Broerse, J.J.; Zürcher, C.; Zwieten, Matthew J. van

doi:10.1016/0090-1229(91)90073-j

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…After marrow grafting, IgG is frequently composed of monoclonal or oligoclonal immunoglobulins of unclear specificity (not against infectious agents) [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] and therefore the protective value of these immunoglobulins in marrow recipients is low. Qualitative comparisons of immunoglobulins will be needed to assess the contribution of humoral immunity to preventing infection after blood stem cell transplantation.…”

Section: Discussionmentioning

confidence: 99%

Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation

Storek

Dawson

Storer

et al. 2001

Blood

353

269

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Allogeneic peripheral blood stem cell grafts contain about 10 times more T and B cells than marrow grafts. Because these cells may survive in transplant recipients for a long time, recipients of blood stem cells may be less immunocompromised than recipients of marrow. Immune reconstitution was studied in 115 patients randomly assigned to receive either allogeneic marrow or filgrastim-mobilized blood stem cell transplantation. Between day 30 and 365 after transplantation, counts of most lymphocyte subsets were higher in the blood stem cell recipients. The difference was most striking for CD4 T cells (about 4-fold higher counts for CD45RA high CD4 T cells and about 2-fold higher counts for CD45RA low/؊ CD4 T cells; P < .05). On assessment using phytohemagglutinin and herpesvirus antigen-stimulated proliferation, T cells in the 2 groups of patients appeared equally functional. Median serum IgG levels were similar in the 2 groups. The rate of definite infections after engraftment was 1.7-fold higher in marrow recipients (P ‫؍‬ .001). The rate of severe (inpatient treatment required) definite infections after engraftment was 2.4-fold higher in marrow recipients (P ‫؍‬ .002). The difference in the rates of definite infections was greatest for fungal infections, intermediate for bacterial infections, and lowest for viral infections. Death associated with a fungal or bacterial infection occurred between day 30 and day 365 after transplantation in 9 marrow recipients and no blood stem cell recipients (P ‫؍‬ .008). In conclusion, blood stem cell recipients have higher lymphocytesubset counts and this appears to result in fewer infections. (Blood. 2001;97:3380-3389)

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Section: Discussionmentioning

confidence: 99%

Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation

Storek

Dawson

Storer

et al. 2001

Blood

353

269

View full text Add to dashboard Cite

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“…However, we could not show obvious evidence for this hypothesis. An alternative explanation for monoclonal gammopathy after cytotoxic treatment has been offered by the report of Van Camp et al [12], who described a case of a patient with acute myelomonoblastic leukemia who presented a transient paraproteinemia during intensive chemotherapy: in the early stages of the normal ontogenesis or during the phase of reconstitution of the immune system after medullar aplasia, the immune response may show a restriction in its normal heterogenity [20]. In the presence of an unknown antigenic stimulus, an insufficient number of clones respond, resulting in the development of homogeneous antibodies.…”

Section: Discussionmentioning

confidence: 99%

Development of a Transient Monoclonal Gammopathy after Chemotherapy in a Patient with Biphenotypic Acute Leukemia

Guariglia

Guastafierro

Annunziata

et al. 2002

Leukemia & Lymphoma

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The development of a IgGk monoclonal gammopathy after a phase of bone marrow aplasia following chemotherapy is described in a patient suffering from biphenotypic acute leukemia (BAL). Paraprotein was followed by the relapse of the disease and disappeared during a further chemotherapy. Paraprotein could have been caused by an additional chemotherapy-induced genetic mutation or by a dysfunction in T-B cooperation observed in the phase of reconstitution of the immune system after medullar aplasia.

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“…Regardless of the final diagnosis, reports of tumors with plasma cell differentiation in non‐human primates are exceedingly rare [2, 10, 17, 21]. Additionally, the cardiac involvement in this case is unique when compared to human tumors and is likely indicative of the aggressive nature of this tumor.…”

Section: Case Reportmentioning

confidence: 93%

Hypergammaglobulinemia in an SIV-Infected Rhesus Macaque with a B-cell neoplasm with plasma cell differentiation

Kramer

Sanders-Beer

Spano

et al. 2011

Journal of Medical Primatology

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Monoclonal gammapathies in long-term surviving Rhesus monkeys after lethal irradiation and bone marrow transplantation

Cited by 6 publications

References 9 publications

Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation

Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation

Development of a Transient Monoclonal Gammopathy after Chemotherapy in a Patient with Biphenotypic Acute Leukemia

Hypergammaglobulinemia in an SIV-Infected Rhesus Macaque with a B-cell neoplasm with plasma cell differentiation

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