Monoclonal gammopathies regardless of subtypes are associated with poor prognosis of diffuse large B-cell lymphoma

Zhang, Yian; Zheng, Wei; Li, Jing; Gao, Rupan; Liu, Peng

doi:10.1097/md.0000000000011719

Cited by 7 publications

(7 citation statements)

References 29 publications

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“…Preceding studies reported a trend towards a better survival for indolent lymphoma patients with a sMC, 13 whereas we identified an impact in the opposite direction concerning the fraction of POD24 patients, PFS, and OS, which is in line with recent studies recognizing the +sIFE as an adverse prognostic factor in DLBCL. [15][16][17]23 This apparent discrepancy with the findings by Economopoulos and colleagues might be explained by the low number of patients with indolent lymphoma included in that study, the histological heterogeneity within the indolent lymphoma group, and the absence of rituximab treatment for historical reasons.…”

Section: Discussioncontrasting

confidence: 73%

“…In DLBCL, several recent studies have reported an impact of a sMC on progression-free survival (PFS) and OS. [14][15][16][17] Likewise, in a small cohort of extranodal marginal zone lymphoma (MZL), the prevalence of a sMC was found to be 27%, and all positive cases had stage IV disease. 18 To our knowledge, no study has examined the prevalence and potential prognostic impact of the presence of a sMC in FL patients in the rituximab era.…”

Section: Introductionmentioning

confidence: 99%

“…In DLBCL, several recent studies have reported an impact of a sMC on progression‐free survival (PFS) and OS 14–17 . Likewise, in a small cohort of extranodal marginal zone lymphoma (MZL), the prevalence of a sMC was found to be 27%, and all positive cases had stage IV disease 18 .…”

Section: Introductionmentioning

confidence: 99%

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Baseline correlations and prognostic impact of serum monoclonal proteins in follicular lymphoma

Mozas¹,

Rivero²,

Rivas‐Delgado³

et al. 2020

Br J Haematol

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The presence of a serum monoclonal component has been associated with poor outcomes in some lymphomas. However, data in follicular lymphoma (FL) are scarce. We studied 311 FL patients diagnosed at a single institution, for whom information on serum immunofixation electrophoresis (sIFE) at diagnosis was available. Baseline characteristics and outcomes were compared between patients with a positive (+sIFE) and a negative sIFE (ÀsIFE). sIFE was positive in 82 patients (26%). Baseline features were comparable between both groups, except for an older age and higher proportion of elevated b 2 -microglobulin levels in the +sIFE group. With a median follow-up of 4.6 years, a +sIFE was associated with a higher risk of early relapse (POD24, 27% vs. 15%, P = 0Á02), shorter progression-free survival (PFS; 42% vs. 52% at 5 years, P = 0Á008), and shorter overall survival (OS; 59% vs. 77% at 10 years, P = 0Á046). In patients >60 years, a +sIFE was an independent predictor of OS [hazard ratio (HR) = 2Á4, 95% confidence interval (CI): 1Á2-5Á0; P = 0Á02]. Approximately one quarter of patients with FL has a +sIFE at diagnosis, which is a predictor of poor outcome. These findings encourage further investigation of its relationship with B-cell biology and the tumour microenvironment.

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Section: Discussioncontrasting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

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Baseline correlations and prognostic impact of serum monoclonal proteins in follicular lymphoma

Mozas¹,

Rivero²,

Rivas‐Delgado³

et al. 2020

Br J Haematol

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“…These findings are also common clinical characteristics of IVLBCL in the large study conducted by Murase et al, 2007 [ 10 ]. While the presence of MG in diffuse large B-cell lymphoma (DLBCL) predicted an inferior overall survival and progression-free survival [ 11 ], prognostic role of MG in IVLBCL is not yet known. In our series, two patients presented with MG and were treated with good outcome.…”

Section: Discussionmentioning

confidence: 99%

Intravascular large B-cell lymphoma in Hispanics: a case series and literature review

Nguyen

Pakbaz

2020

Journal of Community Hospital Internal Medicine Perspectives

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Intravascular large B-cell Lymphoma (IVLBCL) is a rare subtype of extra nodal non-Hodgkin’s lymphoma, which is challenging to diagnose and has a poor prognosis. Here we describe three non-White Hispanic patients newly diagnosed with IVLBCL within 14-month period. All of them presented with persistent fever of unknown origin and symptomatic severe anemia as the initial manifestations. Two out of three cases were successfully diagnosed in a timely manner by fat pad biopsy and have remained disease free up to 34 months after chemotherapy. The third case was diagnosed by bone marrow biopsy and deceased one week later after choosing home hospice care. To date, this is the largest published case series of IVLBCL in non-White Hispanics.

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“…IgG-MG was more frequent in cases with aggressive NHL, while IgM in cases with low risk NHL. MG was mostly associated with advanced stage and had not any prognostic significance on survival [ 57 , 58 ].…”

Section: Protein-protein Interactions On the Surface Of Evs As Modula...mentioning

confidence: 99%

The Role of Intravesicular Proteins and the Protein Corona of Extracellular Vesicles in the Development of Drug-Induced Polyneuropathy

Yunusova

Popova

Udintseva

et al. 2023

CIMB

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Extracellular vesicles (EVs) as membrane structures of cellular origin participating in intercellular communication are involved in the molecular mechanisms of the development of various variants of polyneuropathy. Taking into account the increasing role of the protein corona of EVs and protein-protein interactions on the surface of EVs in the pathogenesis of various diseases, we focused our attention in this review on the role of intravesicular proteins and the protein corona of EVs in the development of chemotherapy-induced polyneuropathy (CIPN). It has been shown that EVs are effectively internalized by the mechanisms of endocytosis and macropinocytosis by neurocytes and glial cells, carry markers of insulin resistance, functionally active proteins (receptors, cytokines, enzymes), and may be involved in the pathogenesis of CIPN. The mechanisms of CIPN associated with the EVs protein corona can be related with the accumulation of heavy chains of circulating IgG in it. G-class immunoglobulins in EVs are likely to have myelin hydrolyzing, superoxide dismutase, and oxidoreductase enzymatic activities. Moreover, circulating IgG-loaded EVs are a place for complement activation that can lead to membrane attack complex deposition in neuroglia and neurons. The mechanisms of CIPN development that are not associated with IgG in the EVs protein corona are somehow related to the fact that many anticancer drugs induce apoptosis of tumor cells, neurons, and neuroglial cells by various mechanisms. This process may be accompanied by the secretion of EVs with modified cargo (HSPs, 20S proteasomes, miRNAs).

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Monoclonal gammopathies regardless of subtypes are associated with poor prognosis of diffuse large B-cell lymphoma

Abstract: Supplemental Digital Content is available in the text

Cited by 7 publications

References 29 publications

Baseline correlations and prognostic impact of serum monoclonal proteins in follicular lymphoma

Baseline correlations and prognostic impact of serum monoclonal proteins in follicular lymphoma

Intravascular large B-cell lymphoma in Hispanics: a case series and literature review

The Role of Intravesicular Proteins and the Protein Corona of Extracellular Vesicles in the Development of Drug-Induced Polyneuropathy

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